HOME >> MEDICINE >> NEWS
Study outlines how stroke, head injury can increase risk of Alzheimer's disease

Researchers from the MassGeneral Institute for Neurodegenerative Disorders (MGH-MIND) have discovered how the death of brain cells caused by a stroke or head injury may cause generation of amyloid-beta protein the key component of senile plaques seen in the brains of patients with Alzheimer's disease. Their report appears in the June 7 issue of the journal Neuron.

We have discovered how a stroke can trigger a series of biochemical events that increase amyloid-beta production in the brain, says Giuseppina Tesco, MD, PhD, of the MGH-MIND Genetics and Aging Research Unit, the papers lead author. These findings raise the prospect of novel therapies that could interfere with this process and reduce the risk of Alzheimers disease in stroke or head trauma patients.

It has been known for several years that strokes and head injuries can increase the risk of Alzheimers disease, but the mechanism underlying that increased risk has not been understood. Alzheimer's disease is characterized by plaques within the brain of amyloid-beta protein, which is toxic to brain cells. Amyloid-beta is formed when the larger amyloid precursor protein (APP) is clipped by two enzymes beta-secretase, also known as BACE, and gamma-secretase which releases the amyloid-beta fragment. The usual processing of APP by an enzyme called alpha-secretase produces an alternative, non-toxic protein.

The MGH-MIND team previously reported that cellular BACE levels are normally controlled by the enzymes breakdown in compartments called lysosomes, a process that is disrupted if a molecular signal on the enzyme is altered. That signal binds to GGA proteins, which are required for the transport of several types of enzymes into lysosomes. One of these proteins, GGA3, can be degraded by caspase, an enzyme takes part in the cell-death process called apoptosis.

In a series of experiments the MGH-MIND researchers revealed how cell death caused by a brain injury,
'"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
6-Jun-2007


Page: 1 2

Related medicine news :

1. Study, meta-analysis examine factors associated with death from heatstroke
2. Study says COPD testing is not measuring up
3. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
4. Study reveals gaps in vaccine financing for underinsured children
5. Study suggests nonpharmaceutical interventions may be helpful in severe influenza outbreaks
6. Study shows radiofrequency ablation highly effective in treating kidney tumors
7. Study says normal but out-of-control enzyme may be culprit that signals some cells to become cancer
8. Study finds HIV protease inhibitor drugs may adversely affect the scaffolding of the cell nucleus
9. Study identifies new regulator of fat metabolism
10. Study shows Diachrome improves blood sugar control in people with type 2 diabetes
11. Study examines characteristics of female high school students who report steroid use

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/20/2017)... ... September 20, 2017 , ... On Thursday, the Triangle ... Work in the Research Triangle for 2017. , Winners were chosen based on ... meet a threshold in employee participation--a percentage that varies based upon the size ...
(Date:9/20/2017)... ... 20, 2017 , ... Doctors on Liens has added the medical group Bones ... working on a personal injury lien basis. Founded by Dr. Wayne Cheng, MD and ... vast experience with orthopedic injuries to patients in the Inland Empire. , Bones and ...
(Date:9/20/2017)... ... September 20, 2017 , ... ... much-anticipated fall event , Look Awesome This Autumn with CoolSculpting®. Scheduled for ... pricing and refreshments. , Mirror Mirror Beauty Boutique is Houston’s largest ...
(Date:9/20/2017)... ... September 20, 2017 , ... Announced that Clear ... commercial support services market) has entered into an agreement on September 1, 2017 ... The PGSD is the first private Dental School to launch an online, accredited ...
(Date:9/20/2017)... ... ... Compliancy Group is proud to announce that its proprietary ... long-time client pass their Department of Health and Human Services (HHS) Office for ... the help of the Compliancy Group's Audit Response Program™, not a single client ...
Breaking Medicine News(10 mins):
(Date:9/7/2017)... , Sept. 7, 2017 NuvoAir ... Smart Spirometer, announced today a partnership with Novartis Pharma AG ... solidifies NuvoAir,s position as the leading mobile spirometry platform and ... patients. ... test ...
(Date:9/6/2017)... ANTONIO , Sept. 6, 2017  Robert G. ... a Pinnacle Professional Member in recognition of his contributions ... Szewc serves as a Nephrologist at the practice of ... emergency medicine, kidney care and hypertension solutions. He has ... 20 years of career experience, as well as expertise ...
(Date:9/6/2017)... -- NeuroRx, a clinical stage biopharma company developing the first ... been granted Fast Track status by the US Food and ... followed by NRX-101 (D-cycloserine + lurasidone). The company will shortly ... therapy targeting patients who are admitted to Emergency Departments with ... ...
Breaking Medicine Technology:
Cached News: