Study results offer guidance in...( e. The COMBINE trial involved a 4.5-hou...),Health

e. The COMBINE trial involved a 4.5-hour intake session and follow-up sessions of up to two hours, as well as contact with up to five specialized staff persons at every visit. This may have increased placebo response such that differences between drugs were very small, even with naltrexone, so I would interpret these outcomes with caution for use in a real-world setting."

Mason-who is co-director of the Pearson Center for Alcoholism and Addiction Research at Scripps Research, director of Scripps Research's Division of Psychopharmacology of the Molecular and Integrative Neurosciences Department, and adjunct faculty at University of Miami School of Medicine and Rockefeller University-is currently conducting ancillary studies to the COMBINE trial at Scripps Research.

Mason's laboratory explores the physiological changes in the brain that drive excessive drinking and create vulnerability to relapse. She also investigates the viability of using new compounds to modulate the neurological effects of alcohol, reduce excessive intake, and prevent relapse. Those interested in participating in one of her clinical trial studies at the Scripps Research La Jolla campus should call (858) 784-7867.

The COMBINE paper, titled "Combined Pharmacotherapies and Behavioral Interventions for Alcohol Dependence," appears in the May 2 issue of the Journal of the American Medical Association (285: 2075-2076). In addition to Mason, the study's authors are: Raymond F. Anton, Stephanie S. O'Malley, Domenic A. Ciraulo, Ron A. Cisler, David Couper, Dennis M. Donovan, James D. Hosking, Bankole A. Johnson, Joseph LoCastro, Richard Longabaugh, Margaret E. Mattson, William R. Miller, Helen M. Pettinati, Carrie L. Randall, Robert Swift, Roger D. Weiss, Lauren D. Williams, and Allen Zweben.

'"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
2-May-2006

Page: 1 2 3
Related medicine news :

1. Study, meta-analysis examine factors associated with death from heatstroke
2. Study says COPD testing is not measuring up
3. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
4. Study reveals gaps in vaccine financing for underinsured children
5. Study suggests nonpharmaceutical interventions may be helpful in severe influenza outbreaks
6. Study shows radiofrequency ablation highly effective in treating kidney tumors
7. Study says normal but out-of-control enzyme may be culprit that signals some cells to become cancer
8. Study finds HIV protease inhibitor drugs may adversely affect the scaffolding of the cell nucleus
9. Study outlines how stroke, head injury can increase risk of Alzheimers disease
10. Study identifies new regulator of fat metabolism
11. Study shows Diachrome improves blood sugar control in people with type 2 diabetes