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Study reveals aspirin's colorectal cancer prevention mechanism

Aspirin therapys ability to reduce the risk of colorectal cancer, an association seen in a large number of studies, appears to depend on the drugs inhibition of the COX-2 enzyme, the action that also underlies aspirins usefulness for treating pain and inflammation. In the May 24 New England Journal of Medicine, investigators from Massachusetts General Hospital (MGH), Dana-Farber Cancer Institute and Brigham and Womens Hospital report that regular aspirin intake only reduced the incidence of colorectal tumors that overexpress COX-2.

"We knew that aspirin can block COX-2 function and that COX-2 is present in the vast majority of colorectal tumors but not in normal colon tissue," explains Andrew Chan, MD, MPH, of the MGH Gastrointestinal Unit, the paper's lead author. "Therefore we hypothesized that, if blocking the COX-2 pathway was the mechanism underlying aspirin-associated risk reduction, it should preferentially reduce the incidence of those tumors that rely on COX-2."

To investigate that theory, the research team compiled data from two ongoing prospective research studies the Nurses Health Study (NHS) and the Health Professionals Follow-Up Study (HPFS). Both studies gather comprehensive health information on their participants every two years, which is analyzed for associations between factors such as diet and the incidence of several diseases. Both the NHS, which enrolls more than 120,000 female registered nurses, and the HPFS, following more than 50,000 men employed in the health professions, have previously found associations between aspirin intake and reduced colorectal cancer risk.

For the current study, the researchers focused on almost 83,000 NHS participants and about 47,000 HPFS participants for whom necessary information was available. They received permission to acquire medical records and pathology reports from those who had reported being diagnosed with colorectal cancer, then retrieved more than 600 patholog
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Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
23-May-2007


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