Study reveals new player in sepsis-associated acute respiratory distres...( ho have acute lung injury. Over the cou...),Health

ho have acute lung injury. Over the course of the disease, Ang-2 levels mirror a patient's condition: they go up as the condition worsens and go down as the patient gets better. They then showed that treating blood vessels grown in the laboratory with blood from patients with ARDS made these blood vessels leaky. They could get the same results with treating the blood vessels with just Ang-2, and they could reverse the leakiness by subsequent treatment with Ang-1, a molecule that antagonizes the actions of Ang-2. Finally, consistent with a key role for Ang-2 in sepsis-associated ARDS, they found that injecting Ang-2 into the blood of healthy mice caused ARDS-like symptoms in these animals.

These results suggest that Ang-2 can serve as a marker of acute lung injury and might be a key player in sepsis-associated ARDS. They raise the possibility that reducing Ang-2 levels in patients might help to prevent or improve this dangerous complication in patients with sepsis. Future studies in patients with sepsis, and in patients with ARDS that is not caused by sepsis, are needed to clarify the roles of Ang-2 and Tie-2 in ARDS and the suitability of Ang-2 as a target for therapy.

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Contact: Paul Ocampo
press@plos.org
415-624-1224
Public Library of Science
23-Jan-2006

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