Study sheds light on the developmental origins of polycystic ovaria...( ater life due to an underlying metaboli...),Health

ater life due to an underlying metabolic problem. In women this problem appears to be associated with PCOS, and is most evident where there is a constellation of symptoms of increasing severity. Hence, I suspect there are at least two pathways that can give rise to overlapping symptoms."

Dr Davies said that events that occurred not only to the mother, but possibly also the grandmother, could have a bearing on the development of a foetus. "To understand the growth of a child, we need to also understand the growth of the parents and possibly the grandparents. A good predictor of one's own birth weight is the birth weight of one's mother."

The study shed light on three aspects of the developmental origins of PCOS, he concluded. "There are reproductive consequences of metabolic programming events that occur during foetal development; we may need to look further back up the generations and look at more factors than previously considered; and finally, adverse events for one generation may have reproductive implications for the next."

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Contact: Mary Rice
mary@mrcommunication.org
European Society for Human Reproduction and Embryology
22-Jun-2005

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