HOME >> MEDICINE >> NEWS
Study shows how herpes infects cornea, evades immune cells

Herpes virus has an unusual strategy for infecting cornea cells that may also explain how it evades the immune system, according to a study by researchers at the University of Illinois at Chicago College of Medicine.

The study appears in the Sept. 25 issue of the Journal of Cell Biology.

Both strains of the herpes virus -- HSV-1, the strain that causes cold sores on the mouth, and HSV-2, genital herpes -- can infect the cornea, the clear, domed surface that forms the eye's outermost layer. Ocular herpes is the leading cause of infectious blindness in the United States, with 50,000 new or recurring cases each year.

In about one quarter of cases, the virus penetrates the first layer of the cornea to infect an inner layer, the stroma, making the disease much more difficult to treat.

Effective treatment is hampered by poor understanding of how the virus infects the stroma, says Deepak Shukla, assistant professor of ophthalmology and visual science and microbiology and immunology, and senior author of the paper. In their study, he and his coworkers determined that the HSV-1 virus enters stroma cells in a process similar to the way bacteria, viruses and other foreign invaders are engulfed by immune cells called phagocytes.

"In the electron microscope pictures, it looks like the stroma cells form long arms that reach out and collect the virus particles, and then wrap around them, forming a sac, and bring them into the cell body," Shukla said.

In phagocytes, ingested foreign particles are destroyed in the sacs, which are highly acidic. But even though the sacs formed by the stroma cells were similar to the phagocyte's sacs, Shukla said, the envelope containing the herpes virus genome emerges from the sac undamaged and able to infect the cell. "This raises the interesting possibility that herpes may be able to evade the immune system defenses in the same way," he said.

"Understanding herpes' unusual pathw
'"/>

Contact: Jeanne Galatzer-Levy
jgala@uic.edu
312-996-1583
University of Illinois at Chicago
25-Sep-2006


Page: 1 2

Related medicine news :

1. Study, meta-analysis examine factors associated with death from heatstroke
2. Study says COPD testing is not measuring up
3. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
4. Study reveals gaps in vaccine financing for underinsured children
5. Study suggests nonpharmaceutical interventions may be helpful in severe influenza outbreaks
6. Study shows radiofrequency ablation highly effective in treating kidney tumors
7. Study says normal but out-of-control enzyme may be culprit that signals some cells to become cancer
8. Study finds HIV protease inhibitor drugs may adversely affect the scaffolding of the cell nucleus
9. Study outlines how stroke, head injury can increase risk of Alzheimers disease
10. Study identifies new regulator of fat metabolism
11. Study shows Diachrome improves blood sugar control in people with type 2 diabetes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term insurance that ... insurance companies have a waiver for care if the client has a cognitive impairment ... family pays for care, is often waived, so the benefits from their insurance start ...
(Date:10/13/2017)... ... ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, has released a ... books in the Holy Scriptures, Revelation. The Book of Revelation paints a picture of ... have tossed it off as mere rubbish, but Yisrayl Hawkins says that is because ...
(Date:10/13/2017)... ... ... “America On The Brink”: the Christian history of the United States and the ... published author, William Nowers. Captain Nowers and his wife, Millie, have six children, ... in the Navy. Following his career as a naval aviator and carrier pilot, ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... to meet the demand of today’s consumer and regulatory authorities worldwide. From Children’s ... experts and tested to meet the highest standard. , These products are ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... drug delivery system that we intend to develop to enable prevention of a ... lead to severe hearing loss, especially in pediatric patients. For cisplatin, hearing loss ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... AVACEN Medical , Inc. (AVACEN) announced that Frost & ... Innovation Award for Its fibromyalgia pain management device. The ... market research by Frost & Sullivan,s industry experts. ... product, the AVACEN 100, offers a safe and effective solution ... ...
(Date:10/11/2017)... , Oct. 11, 2017  Caris Life Sciences ... on fulfilling the promise of precision medicine, today announced ... joined Caris, Precision Oncology Alliance™ (POA) as its 17 ... centers, the St. Jude Crosson Cancer Institute will help ... the use of tumor profiling, making cancer treatment more ...
(Date:10/10/2017)... , Oct. 10, 2017   West Pharmaceutical Services, ... solutions for injectable drug administration, today shared the results ... Adapter for improving the intradermal administration of polio vaccines. ... Vaccination Summit in May 2017 by Dr. Ondrej ... Department, World Health Organization (WHO), and recently published in ...
Breaking Medicine Technology:
Cached News: