HOME >> MEDICINE >> NEWS
Subtypes of ependymomas arise from rare stem cells in the nervous system

Brain tumors called ependymomas that occur in different parts of the central nervous system appear to arise from subpopulations of stem cells called radial glia cells (RGCs), according to investigators at St. Jude Children's Research Hospital. The discovery explains why some identical-looking ependymomas are actually distinctly different diseases, the researchers said.

This new information, in combination with the techniques used to conduct the study, holds promise for designing more effective treatments for ependymomas as well as for other solid tumors. A report on this work appears in the October issue of Cancer Cell. RGCs are unspecialized cells that line the surface of the ventricles (fluid-filled spaces in the brain) and the spinal cord, and give rise to normal mature cells in the nervous system. The St. Jude study found strong evidence that when rare populations of RGCs acquire mutations that disrupt the cell signaling pathways controlling growth and differentiation, these cells reproduce continually and give rise to an ependymoma.

The St. Jude finding that RGCs can give rise to these tumors is consistent with evidence from a variety of researchers that cancers arise from, and are maintained by, a rare number of mutated stem cells called cancer stem cells, according to Richard Gilbertson, M.D., Ph.D., associate member in the Developmental Neurobiology and the Hematology-Oncology departments. Gilbertson is senior author of the Cancer Cell paper.

The current discovery at St. Jude explains why ependymomas arising in various parts of the central nervous system are clinically different, even though they look the same histologically (as seen under a microscope), the St. Jude researcher said. For example, although all ependymomas look alike, supratentorial ependymomas arise in the top part of the brain in both adults and children; often cause weakness in the arms and legs, visual problems and seizures; and have a survival rate of 50-60 percent. P
'"/>

Contact: Kelly Perry
kelly.perry@stjude.org
901-495-3306
St. Jude Children's Research Hospital
17-Oct-2005


Page: 1 2 3

Related medicine news :

1. One new case of dementia arises every seven seconds
2. New cause of tamoxifen resistance in breast cancer cells discovered at Lombardi
3. Study says normal but out-of-control enzyme may be culprit that signals some cells to become cancer
4. New algorithm matches any tumor cells to best possible anti-cancer treatments
5. Aging stem cells in mice may hold answers to diseases of the aged, Stanford study finds
6. Loss of stem cells correlates with premature aging in animal study
7. UCLA researchers develop new nanomaterials to deliver anti-cancer drugs to cells
8. Trial shows circulating tumor cells predict how prostate cancer patients do with chemotherapy
9. Stanford researchers track human stem cells transplanted into rat brain
10. Nurse cells make life and death decisions for infection-fighting cells
11. Adult brain cells rediscover their inner child

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/2/2020)... ... 02, 2020 , ... The Coronavirus (COVID-19) pandemic resulted in ... conjunction with the American Dental Association and Centers for Disease Control and Prevention, ... Due to safety concerns, the announcement sparked hesitancy among some hygienists, who protested ...
(Date:7/1/2020)... Texas (PRWEB) , ... July 01, 2020 , ... ... announced today that it has been selected by Codiak BioSciences to support its ... PODs will provide the cleanroom infrastructure for the drug substance and product manufacturing ...
(Date:6/28/2020)... ... June 26, 2020 , ... ... and the general public. As a supplier of top-quality masks, sanitizers and thermometers, ... for PPE equipment. President Priya Agarwal observed, “All of our masks are manufactured ...
(Date:6/25/2020)... ... June 25, 2020 , ... Denials Management, Inc. has ... the key steps when filing appeals for denials of mental health and substance use ... educate individuals about their appeal rights and explain the steps in the appeals process. ...
(Date:6/24/2020)... (PRWEB) , ... June 24, 2020 , ... The world’s ... cost comparison survey that details which cell phones will be worth the most two ... brands on the market - iPhone, Samsung, Google, Sony and LG - and compared ...
Breaking Medicine News(10 mins):
(Date:6/25/2020)... ... June 25, 2020 , ... ... analysts Top App Developers & DesignRush following the launch a recent project. BeCurious ... exercise/community platform for cancer survivors. , Commissioned by MyVictory Inc , ...
(Date:6/25/2020)... ... June 25, 2020 , ... Drs. Gregory Toback and ... within the Periodontics category. As specialists, this team of periodontists offers ... RI. Laser gum disease therapy, minimally invasive gum recession treatment, and life-changing dental ...
(Date:6/23/2020)... (PRWEB) , ... June 23, 2020 , ... ... official launch of its refreshed brand and new website, which can be found ... industry, offering federal and state agencies comprehensive, cutting-edge solutions — and this rebrand ...
Breaking Medicine Technology:
Cached News: