HOME >> MEDICINE >> NEWS
Synthetic protein eases arthritis symptoms in mice

A lab-made version of a human protein alleviates symptoms of both acute and chronic arthritis in mice and could be the basis for a new arthritis drug for people, report scientists from the National Institute of Allergy and Infectious Disease (NIAID), part of the National Institutes of Health (NIH). The protein prevents the assembly of a cell surface receptor, thus blocking transmission of chemical signals that lead to arthritis symptoms.

"This study opens a new research avenue to better understand and, perhaps, to treat rheumatoid arthritis, a condition that causes suffering in more than two million Americans," says NIAID Director Anthony S. Fauci, M.D.

Investigators from NIAID's Laboratory of Immunology, led by Michael Lenardo, M.D., published their findings in the October issue of Nature Medicine, now available online. The idea that the protein, called pre-ligand assembly domain protein or PLAD, might play a role in thwarting the joint inflammation characteristic of rheumatoid arthritis--one of the most common autoimmune diseases--grew out of their research on a very rare autoimmune disease called autoimmune lymphoproliferative syndrome (ALPS).

Previously, Dr. Lenardo and his colleagues showed that in ALPS a form of PLAD blocks a cell surface receptor and prevents a needed chemical signaling pathway from functioning correctly. In ALPS, the signal pathway interrupted by PLAD leads to disease symptoms. But, the scientists reasoned, PLAD might also be able to block a related cell surface receptor--one involved in passing signals that lead to inflammation. In theory, inhibiting this pathway might benefit people with rheumatoid arthritis, who suffer from excessive inflammation.

A key promoter of inflammation is a chemical called tumor necrosis factor alpha (TNF-alpha). TNF-alpha starts a chemical chain reaction leading to inflammation by binding to two cell surface receptors, TNFR-1 and TNFR-2. Naturally occurring PLAD helps both forms
'"/>

Contact: Anne A. Oplinger
aoplinger@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
3-Oct-2005


Page: 1 2

Related medicine news :

1. Synthetic production of potential pharmaceuticals dramatically simplified by Scripps research team
2. Synthetic version of scorpion venom delivers radioactive iodine to malignant brain tumors
3. Draining away brains toxic protein to stop Alzheimers
4. Penn study finds pro-death proteins required to regulate healthy immune function
5. Blocking stress protein decreases Alzheimers peptide in mice
6. Fat protein cuts blood vessel inflammation, may help heart, Jefferson scientists find
7. OHSU Cancer Institute researcher identifies protein marker for prostate cancer survival
8. Cow protein aids in treatment of gastrointestinal disorder
9. Study implicates protein as a trigger of advanced prostate cancer recurrence
10. Speeding fingertip discovery -- 20 years of protein info in 1 place
11. Head and neck cancer vaccine targets proteins to create immune response

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Synthetic protein eases arthritis symptoms mice

(Date:7/31/2014)... -- The virus that causes cold sores -- herpes simplex ... symptoms, according to a new study. Researchers in ... people infected with the virus. This explains why some people ... get them only occasionally. The authors said the findings could ... thought when the disease was dormant, it was a truce. ...
(Date:7/31/2014)... York, NY (PRWEB) July 31, 2014 ... Ovarian Cancer Coalition will be featured in the ... space is being donated by EHE International, an ... care management. The eye-catching window display, designed in ... flip-flops symbolizing women’s footsteps, in a ratio that ...
(Date:7/31/2014)... Kansas City, MO (PRWEB) July 31, 2014 ... recently recognized with an Excellence Through Insight award for ... Healthcare Providers and Systems (CG-CAHPS) database in multiple categories ... honor for their commitment to excellence in patient care. ... must have been a patient satisfaction-tracking client of HealthStream ...
(Date:7/31/2014)... July 31, 2014 Six schools of nursing ... for 2014 to 2018, bringing the total to 35, the ... selection is by competitive application reviewed by a panel of ... first-time COE designees. , As in previous years, the new ... Education Summit during the NLN Banquet. Deans and other ...
(Date:7/31/2014)... 2014 Shiitakes have been called “The ... for Quick-Fix Spaghetti Sauce below, they cook up in ... valued for their deep flavor -- four to ten ... of the foods they're cooked with, so they add ... low-fat nutrition. Shiitakes are rich in fiber and contain ...
Breaking Medicine News(10 mins):Health News:Cold Sore Virus Active Without Symptoms, Study Finds 2Health News:National Ovarian Cancer Coalition to be Featured in New York’s Rockefeller Center Window during August to Raise Awareness and Promote Education about Ovarian Cancer 2Health News:National Ovarian Cancer Coalition to be Featured in New York’s Rockefeller Center Window during August to Raise Awareness and Promote Education about Ovarian Cancer 3Health News:Saint Luke’s Health System Physicians and Clinics Earn Excellence through Insight Awards for Overall Patient Experience in the CG-CAHPS Database 2Health News:Saint Luke’s Health System Physicians and Clinics Earn Excellence through Insight Awards for Overall Patient Experience in the CG-CAHPS Database 3Health News:Six Schools of Nursing Named National League for Nursing Centers of Excellence in Nursing Education for 2014-18 2Health News:Six Schools of Nursing Named National League for Nursing Centers of Excellence in Nursing Education for 2014-18 3Health News:Quick Fixin’ Summertime Meals with Shiitake Mushrooms -- Bring ‘em Home and Grow Your Own 2Health News:Quick Fixin’ Summertime Meals with Shiitake Mushrooms -- Bring ‘em Home and Grow Your Own 3
(Date:7/31/2014)... Vermillion, Inc. (NASDAQ: VRML), a multivariate diagnostics company ... conference call on Thursday, August 14, 2014, at 4:30 p.m. ... June 30, 2014. Financial results will be issued in a ... President and CEO James LaFrance will host the ... Date: Thursday, August 14, 2014 Time: 4:30 p.m. Eastern time ...
(Date:7/31/2014)... , July 31, 2014  Today, Levi ... new extension to its PageCenterX ® content ... is designed to provide downtime reporting capabilities to ... LRS is releasing the product for general availability, ... EMR applications experience outages for a variety of ...
(Date:7/31/2014)... WOONSOCKET, R.I. and WASHINGTON ... URAC announced today that CVS/pharmacy is the first ... Community Pharmacy accreditation from URAC, the leading health ... the health care industry. All CVS/pharmacy and Longs ... URAC has over 30 accreditation ...
Breaking Medicine Technology:Vermillion Sets Second Quarter 2014 Conference Call for Thursday, August 14, 2014 2LRS Announces Downtime Reporting Solution for Healthcare 2CVS/pharmacy Earns First-Ever Community Pharmacy Accreditation from URAC 2CVS/pharmacy Earns First-Ever Community Pharmacy Accreditation from URAC 3
Cached News: