HOME >> MEDICINE >> NEWS
Synthetic protein eases arthritis symptoms in mice

A lab-made version of a human protein alleviates symptoms of both acute and chronic arthritis in mice and could be the basis for a new arthritis drug for people, report scientists from the National Institute of Allergy and Infectious Disease (NIAID), part of the National Institutes of Health (NIH). The protein prevents the assembly of a cell surface receptor, thus blocking transmission of chemical signals that lead to arthritis symptoms.

"This study opens a new research avenue to better understand and, perhaps, to treat rheumatoid arthritis, a condition that causes suffering in more than two million Americans," says NIAID Director Anthony S. Fauci, M.D.

Investigators from NIAID's Laboratory of Immunology, led by Michael Lenardo, M.D., published their findings in the October issue of Nature Medicine, now available online. The idea that the protein, called pre-ligand assembly domain protein or PLAD, might play a role in thwarting the joint inflammation characteristic of rheumatoid arthritis--one of the most common autoimmune diseases--grew out of their research on a very rare autoimmune disease called autoimmune lymphoproliferative syndrome (ALPS).

Previously, Dr. Lenardo and his colleagues showed that in ALPS a form of PLAD blocks a cell surface receptor and prevents a needed chemical signaling pathway from functioning correctly. In ALPS, the signal pathway interrupted by PLAD leads to disease symptoms. But, the scientists reasoned, PLAD might also be able to block a related cell surface receptor--one involved in passing signals that lead to inflammation. In theory, inhibiting this pathway might benefit people with rheumatoid arthritis, who suffer from excessive inflammation.

A key promoter of inflammation is a chemical called tumor necrosis factor alpha (TNF-alpha). TNF-alpha starts a chemical chain reaction leading to inflammation by binding to two cell surface receptors, TNFR-1 and TNFR-2. Naturally occurring PLAD helps both forms
'"/>

Contact: Anne A. Oplinger
aoplinger@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
3-Oct-2005


Page: 1 2

Related medicine news :

1. Synthetic production of potential pharmaceuticals dramatically simplified by Scripps research team
2. Synthetic version of scorpion venom delivers radioactive iodine to malignant brain tumors
3. Draining away brains toxic protein to stop Alzheimers
4. Penn study finds pro-death proteins required to regulate healthy immune function
5. Blocking stress protein decreases Alzheimers peptide in mice
6. Fat protein cuts blood vessel inflammation, may help heart, Jefferson scientists find
7. OHSU Cancer Institute researcher identifies protein marker for prostate cancer survival
8. Cow protein aids in treatment of gastrointestinal disorder
9. Study implicates protein as a trigger of advanced prostate cancer recurrence
10. Speeding fingertip discovery -- 20 years of protein info in 1 place
11. Head and neck cancer vaccine targets proteins to create immune response

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Synthetic protein eases arthritis symptoms mice

(Date:11/28/2014)... Brosix is always making changes to its infrastructure architecture ... efficient, effective, and secure experience. Most recently, the company ... ability to setup local servers for each country or ... around the globe. , 2. The ability to setup ... require millions of users in one network. , 3. ...
(Date:11/28/2014)... Dr. Diane Walder, one of the South ... Dr. Bridgit Nolan to her practice as a cosmetic ... her dermatology residency at the University of Miami Miller ... Nolan to join her practice because of her ... only does Dr. Nolan strive to provide the utmost ...
(Date:11/28/2014)... (PRWEB) November 28, 2014 Mirena ... move forward in New Jersey’s Bergen County Superior ... consolidated litigation established there is quickly approaching 1,300, ... on November 18th shows 1,293 lawsuits now pending ... lawsuits that allege complications resulting from spontaneous migration ...
(Date:11/28/2014)... 28, 2014 Miami's Plastic Surgery of ... Practice founder Dr. Jeffrey Epstein is excited ... a groundbreaking WordPress platform, the site is uniquely designed ... Currently, up to 75% of all prospective rhinoplasty patients ... people are logging on with smartphones, tablets, and laptops, ...
(Date:11/28/2014)... 28, 2014 Secura Consultants, based ... insurance marketing organizations in the country focused on ... protection marketplace. Secura Consultants is proud to offer ... Financial Group, a leading global financial company. , ... With the ownership interest comes the need for ...
Breaking Medicine News(10 mins):Health News:Brosix Infrastructure Architecture Changes to Benefit Users 2Health News:Dr. Diane Walder Welcomes New Cosmetic Dermatologist to Practice 2Health News:Nearly 1,300 Mirena Lawsuits Now Filed in Consolidated New Jersey Litigation, Bernstein Liebhard LLP Reports 2Health News:Nearly 1,300 Mirena Lawsuits Now Filed in Consolidated New Jersey Litigation, Bernstein Liebhard LLP Reports 3Health News:Top Rhinoplasty Surgeon Launches Innovative Website 2Health News:Secura Consultants Offers Complimentary Buy-Sell Agreement Reviews 2
(Date:11/28/2014)... endedChange %  30 September 201430 September 2013Turnover 546,011 , 534,641 ... 384,242 , 339,113 , 13.3 Hospital ... , 49.5 Medical Insurance Administration Service Income , ... and Accessories Sales , 94,580 , 142,683 ... , 9,219 , (68.4) Impairment Loss on Fixed ...
(Date:11/26/2014)... Nov. 26, 2014  Thoratec Corporation (NASDAQ: ... support therapies to save, support and restore failing hearts, ... investor conferences. On Tuesday, December 2, the ... Piper Jaffray Healthcare Conference.  D. Keith Grossman , ... on the company beginning at 11:30 a.m., Eastern Standard ...
(Date:11/26/2014)... , Nov. 26, 2014  Cohen, Placitella ... behalf of investors who purchased Nymox Pharmaceutical Corporation ... during the period from January 31, 2011 through ... whether Nymox and certain of its officers and ... in violation of Sections 10(b) and 20(a) of ...
Breaking Medicine Technology:Golden Meditech Announces 2014 / 2015 Interim Results 2Golden Meditech Announces 2014 / 2015 Interim Results 3Golden Meditech Announces 2014 / 2015 Interim Results 4Golden Meditech Announces 2014 / 2015 Interim Results 5Golden Meditech Announces 2014 / 2015 Interim Results 6Golden Meditech Announces 2014 / 2015 Interim Results 7Golden Meditech Announces 2014 / 2015 Interim Results 8Thoratec Announces Presentations At Investor Conferences For December 2014 2Cohen, Placitella & Roth, PC Investigating Nymox Pharmaceutical Corporation for Failing to Disclose Material Information 2Cohen, Placitella & Roth, PC Investigating Nymox Pharmaceutical Corporation for Failing to Disclose Material Information 3
Cached News: