HOME >> MEDICINE >> NEWS
TLR4 gene found to protect against tumor development

A new study finds that a gene which plays an important role in immune function, known as toll-like receptor 4 (TLR4), may also play a critical role in suppressing chronic lung inflammation and tumor development in mice.

"We know that chronic inflammation predisposes people to many types of cancer," says NIH Director Elias Zerhouni, M.D. "By using this new information we may be able to suppress chronic inflammation and reduce our Nation's cancer burden."

In the December 7, 2005 issue of the Journal of the National Cancer Institute, researchers at the National Institute of Environmental Health Sciences (NIEHS), a part of the National Institutes of Health, report that mice prone to lung cancer that had TLR4 removed or altered had 60 percent more tumors than mice that had intact receptors, illustrating a new protective role for this gene. There were no differences in overall tumor size or structure between the mice. TLR4 is part of what immunologists refer to as the "innate immune system" which acts as the body's first line of defense against harmful substances.

Researchers explain the immune system actually is comprised of two components or systems, the innate and the acquired. The innate system can be thought of as the way the body is naturally programmed to respond, forming the front line of defense against infection. The acquired depends on the development of antibodies and other systems to recognize pathogens and other foreign objects that might upset the body's ability to fight off diseases. Understanding more about how the innate system works will help inform how the more complex, acquired system works.

"We have recently learned a lot about TLR4, its different mutations, and the role they play in immunity," said David A. Schwartz, MD, the NIEHS Director, "but discovering this novel function of TLR4 in tumor biology may provide new therapeutic targets for many chronic diseases, including cancer."

"We can't
'"/>

Contact: Robin Mackar
rmackar@niehs.nih.gov
919-541-0073
NIH/National Institute of Environmental Health Sciences
7-Dec-2005


Page: 1 2

Related medicine news :

1. OFTs value-based pricing scheme is well-founded, but could increase overall NHS drug spend
2. Certain combination therapy found more effective for treating malaria in African children
3. Antifolate therapies found effective against certain type of malaria
4. High-quality child care for poor children found to offset the risk of later depression
5. No link found between autism and celiac disease
6. Correlation between bile duct obstruction and ductal cancer found
7. The root of dyscalculia found
8. Link found between teens stress levels and acne severity
9. CRP liver protein induces hypertension, UT Southwestern researchers have found
10. Link found between muscle damage during childbirth, condition causing fallen bladder, uterus
11. Grants from leading eye research foundation surpass $9M in 2006

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: TLR4 gene found protect against tumor development

(Date:10/31/2014)... 2014 Radiology and EMR Integration ... difference between diagnostic imaging centers but Connectivity is ... DigitalOne. “Differentiation is critical in all businesses ... you consider the intense competition and the downward ... will stand-out from the competition by fully integrating ...
(Date:10/31/2014)... Oct. 31, 2014 (HealthDay News) -- Carving pumpkins and ... send many children to emergency rooms in the United ... holidays, Halloween had the fifth highest number of ER ... to 2007-2013 data from the National Electronic Injury Surveillance ... involved the head, noted the American Academy of Orthopaedic ...
(Date:10/31/2014)... of Health will facilitate communication among scientists, clinicians, ... from diagnosis to treatment. The Research Domain Criteria ... Institute of Mental Health (NIMH), part of NIH, ... initiative. , The aim of the RDoC ... that translates basic science into clinical settings by ...
(Date:10/31/2014)... News) -- A comparison of two of the most ... gastric bypass helped patients shed more excess pounds than ... short-term complications and long-term hospitalizations. Gastric-bypass surgery makes ... your body does not absorb all the calories from ... Health. Gastric banding is a type of weight-loss procedure ...
(Date:10/31/2014)... HealthDay Reporter THURSDAY, Oct. 30, 2014 (HealthDay ... of broken bones and injured joints, a new study reports. ... percent of people who had an eczema flare-up in the past ... percent had an injury that caused a limitation of function. ... had more than double the risk of having had a fracture ...
Breaking Medicine News(10 mins):Health News:Diagnostic Imaging of Salem Expects Growth Partnering with DigitalOne 2Health News:Halloween at the ER Is No Treat 2Health News:NIMH creates new unit to support its research domain criteria initiative 2Health News:Study Compares 2 Common Weight-Loss Surgeries 2Health News:Study Compares 2 Common Weight-Loss Surgeries 3Health News:Eczema Tied to Bone Fracture Risk in Study 2
(Date:10/31/2014)... 2014  Encision Inc. (OTCQB:ECIA), a medical device company ... burns in minimally invasive surgery, today announced financial results ... 2014. The Company posted quarterly net revenue ... $414 thousand, or $(0.04) per share. These results compare ... loss of $50 thousand, or $(0.01) per share, in ...
(Date:10/31/2014)... , Oct. 30, 2014 Electronic ... electronic transmission of prescription related information between ... system allows a physician and nurse practitioner ... a medication error occurs during pharmacy operations. ... applications. It provides complete medical lists, conducts ...
(Date:10/30/2014)... , Oct. 30, 2014  Misonix, Inc. (NASDAQ: ... company that designs, manufactures and markets innovative therapeutic ultrasonic ... announced today that it will report financial results for ... 6, 2014. The Company has scheduled a conference call ... pm ET to review the results. ...
Breaking Medicine Technology:Encision Reports Second Quarter Fiscal Year 2015 Results 2Encision Reports Second Quarter Fiscal Year 2015 Results 3Encision Reports Second Quarter Fiscal Year 2015 Results 4Encision Reports Second Quarter Fiscal Year 2015 Results 5E-Prescribing Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast, 2013 - 2019 2Misonix, Inc. To Report First Quarter Fiscal Year 2015 Financial Results On Thursday, November 6, 2014 2
Cached News: