HOME >> MEDICINE >> NEWS
TLR4 gene found to protect against tumor development

A new study finds that a gene which plays an important role in immune function, known as toll-like receptor 4 (TLR4), may also play a critical role in suppressing chronic lung inflammation and tumor development in mice.

"We know that chronic inflammation predisposes people to many types of cancer," says NIH Director Elias Zerhouni, M.D. "By using this new information we may be able to suppress chronic inflammation and reduce our Nation's cancer burden."

In the December 7, 2005 issue of the Journal of the National Cancer Institute, researchers at the National Institute of Environmental Health Sciences (NIEHS), a part of the National Institutes of Health, report that mice prone to lung cancer that had TLR4 removed or altered had 60 percent more tumors than mice that had intact receptors, illustrating a new protective role for this gene. There were no differences in overall tumor size or structure between the mice. TLR4 is part of what immunologists refer to as the "innate immune system" which acts as the body's first line of defense against harmful substances.

Researchers explain the immune system actually is comprised of two components or systems, the innate and the acquired. The innate system can be thought of as the way the body is naturally programmed to respond, forming the front line of defense against infection. The acquired depends on the development of antibodies and other systems to recognize pathogens and other foreign objects that might upset the body's ability to fight off diseases. Understanding more about how the innate system works will help inform how the more complex, acquired system works.

"We have recently learned a lot about TLR4, its different mutations, and the role they play in immunity," said David A. Schwartz, MD, the NIEHS Director, "but discovering this novel function of TLR4 in tumor biology may provide new therapeutic targets for many chronic diseases, including cancer."

"We can't
'"/>

Contact: Robin Mackar
rmackar@niehs.nih.gov
919-541-0073
NIH/National Institute of Environmental Health Sciences
7-Dec-2005


Page: 1 2

Related medicine news :

1. OFTs value-based pricing scheme is well-founded, but could increase overall NHS drug spend
2. Certain combination therapy found more effective for treating malaria in African children
3. Antifolate therapies found effective against certain type of malaria
4. High-quality child care for poor children found to offset the risk of later depression
5. No link found between autism and celiac disease
6. Correlation between bile duct obstruction and ductal cancer found
7. The root of dyscalculia found
8. Link found between teens stress levels and acne severity
9. CRP liver protein induces hypertension, UT Southwestern researchers have found
10. Link found between muscle damage during childbirth, condition causing fallen bladder, uterus
11. Grants from leading eye research foundation surpass $9M in 2006

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: TLR4 gene found protect against tumor development

(Date:3/28/2015)... Rocket Pure , a manufacturer of natural body care ... natural sunscreen. They are offering the sunscreen in both ... with a bonus lip balm sunscreen. , The new products ... Click to see the natural sunscreen on Amazon . , ... with non-nano zinc oxide and provides broad-based protection against UVA ...
(Date:3/28/2015)... March 28, 2015 Coffee could not only ... protect you from gum disease, researchers have found. , They ... disease. , Coffee contains antioxidants. Antioxidants fight gum disease. Does ... researchers at Boston Univ. Henry M. Goldman School of Dental ... August 2014 issue of the Journal of Periodontology. , “This ...
(Date:3/28/2015)... Could genetic code determine someone’s coffee habit? ... by researchers at the Harvard T.H. Chan School of ... the Coffee and Caffeine Genetics Consortium and published ... the study—one of several recent HSPH investigations of the ... than 120,000 regular coffee drinkers of European and African ...
(Date:3/28/2015)... "Necrorun" was featured on NewsWatch as part of ... latest and coolest applications on the market for iOS, ... and technology expert, conducted the app review and shared ... game with knights, nature, and peasants. , The ... to Eurogamer. The popularity of these games grew over ...
(Date:3/28/2015)... (PRWEB) March 28, 2015 Take a ... system kicks into action. Acids tumble into the stomach, ... a faulty valve-like structure lets these acids run amok, ... an extremely common symptom. More than 60 million Americans ... slides examine where heartburn starts, and how it can ...
Breaking Medicine News(10 mins):Health News:Rocket Pure Releases New Natural Sunscreens For Athletes 2Health News:Rocket Pure Releases New Natural Sunscreens For Athletes 3Health News:New Research Impliments Coffee May Help Fight Gum Disease and Increasing Benefits With Tylers Coffee 2Health News:How Coffee Habits Relate to Our Genetic Code and Enhancing the Caffeine Experience 2Health News:How Coffee Habits Relate to Our Genetic Code and Enhancing the Caffeine Experience 3Health News:A Grim Endless Runner Game Was Featured on NewsWatch Television on January 30, 2015 2Health News:Bypass Your Heartburn Worries This Easter With Tylers Coffee 2
(Date:3/27/2015)... 2015 BioCorRx, Inc. ( BICX ... is a healthcare solutions organization, which focuses solely ... $22 billion in the U.S. alone. The Company created a ... in a specially compounded form for outpatient surgical implantation. The ... and New Zealand ) to the specially ...
(Date:3/27/2015)... CHAPEL HILL, N.C. , March 27, 2015 /PRNewswire/ ... function is essential to meeting challenges in clinical development, ... and face tighter regulations, the Medical Affairs function is ... charted by mature markets. According to ... market study participants have a group dedicated to Medical ...
(Date:3/27/2015)... , March 27, 2015  The quality function ... description: ensure products meet quality standards at every stage ... escalating regulations, quality leaders also have the challenge of ... Those who don,t effectively balance these priorities ... well as marketplace failure and regulatory scrutiny. ...
Breaking Medicine Technology:Small Cap IR Correction -- BioCorRx Inc. Positions Itself Through Strategic Partnerships To Gain Market Share Of The $22 Billion Substance Abuse Treatment Market In The U.S. 2Medical Affairs Capabilities Expanding in Emerging Marketplaces 2New Medical Device Quality Study Finds Regulatory Environment is Boosting Quality Spending, Especially for Large Companies 2
Cached News: