HOME >> MEDICINE >> NEWS
TLR4 gene found to protect against tumor development

A new study finds that a gene which plays an important role in immune function, known as toll-like receptor 4 (TLR4), may also play a critical role in suppressing chronic lung inflammation and tumor development in mice.

"We know that chronic inflammation predisposes people to many types of cancer," says NIH Director Elias Zerhouni, M.D. "By using this new information we may be able to suppress chronic inflammation and reduce our Nation's cancer burden."

In the December 7, 2005 issue of the Journal of the National Cancer Institute, researchers at the National Institute of Environmental Health Sciences (NIEHS), a part of the National Institutes of Health, report that mice prone to lung cancer that had TLR4 removed or altered had 60 percent more tumors than mice that had intact receptors, illustrating a new protective role for this gene. There were no differences in overall tumor size or structure between the mice. TLR4 is part of what immunologists refer to as the "innate immune system" which acts as the body's first line of defense against harmful substances.

Researchers explain the immune system actually is comprised of two components or systems, the innate and the acquired. The innate system can be thought of as the way the body is naturally programmed to respond, forming the front line of defense against infection. The acquired depends on the development of antibodies and other systems to recognize pathogens and other foreign objects that might upset the body's ability to fight off diseases. Understanding more about how the innate system works will help inform how the more complex, acquired system works.

"We have recently learned a lot about TLR4, its different mutations, and the role they play in immunity," said David A. Schwartz, MD, the NIEHS Director, "but discovering this novel function of TLR4 in tumor biology may provide new therapeutic targets for many chronic diseases, including cancer."

"We can't
'"/>

Contact: Robin Mackar
rmackar@niehs.nih.gov
919-541-0073
NIH/National Institute of Environmental Health Sciences
7-Dec-2005


Page: 1 2

Related medicine news :

1. OFTs value-based pricing scheme is well-founded, but could increase overall NHS drug spend
2. Certain combination therapy found more effective for treating malaria in African children
3. Antifolate therapies found effective against certain type of malaria
4. High-quality child care for poor children found to offset the risk of later depression
5. No link found between autism and celiac disease
6. Correlation between bile duct obstruction and ductal cancer found
7. The root of dyscalculia found
8. Link found between teens stress levels and acne severity
9. CRP liver protein induces hypertension, UT Southwestern researchers have found
10. Link found between muscle damage during childbirth, condition causing fallen bladder, uterus
11. Grants from leading eye research foundation surpass $9M in 2006

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... WI (PRWEB) , ... October 13, 2017 , ... As ... in medicine known as “patient engagement.” The patient is doing more than filling out ... partners. , “There is an increasing emphasis in health care and research on ...
(Date:10/13/2017)... LEXINGTON, Ky. (PRWEB) , ... October 13, 2017 , ... ... MD, MPH to become its next President and Chief Executive Officer, succeeding Dr. James ... and CEO Elect beginning July 1, 2018 until Dr. Puffer’s retirement at the end ...
(Date:10/13/2017)... ... ... PurhealthRX , a leading Health and Nutrition Company, is announcing the ... spectrum CBD oil will revolutionize the rapidly growing CBD market by reducing the amount ... into liquid products, while reducing costs to end users. , The team of researchers ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Lori R. Somekh, ... member of ElderCounsel, a national organization of elder law and special needs planning attorneys. ... and rules. It also provides a forum to network with elder law attorneys nationwide,” ...
(Date:10/13/2017)... Calif. (PRWEB) , ... October 13, 2017 , ... Many ... dementia. However, many long-term care insurance companies have a waiver for care if the ... 90-day elimination period, when the family pays for care, is often waived, so the ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... , Oct. 11, 2017  True Health, a ... amplified its effort during National Breast Cancer Awareness ... cancer risks. ... Oncology calculated that more than 10 million American ... mutations in BRCA1 or BRCA2 and have not had ...
(Date:10/7/2017)... Texas , Oct. 6, 2017   Provista, ... with more than $100 billion in purchasing power, today ... news and information. The Newsroom is the ... and industry trends, infographics, expert bios, news releases, slideshows ... having access to a wealth of resources at their ...
(Date:10/4/2017)... Oct. 4, 2017 OBP Medical ... illuminating medical devices, today announced regulatory approval from ... Agency (or Agência Nacional de Vigilância Sanitária (ANVISA)) ... cordless surgical retractor with integrated LED light source ... illumination and exposure of a tissue pocket or ...
Breaking Medicine Technology:
Cached News: