HOME >> MEDICINE >> NEWS
TLR4 gene found to protect against tumor development

A new study finds that a gene which plays an important role in immune function, known as toll-like receptor 4 (TLR4), may also play a critical role in suppressing chronic lung inflammation and tumor development in mice.

"We know that chronic inflammation predisposes people to many types of cancer," says NIH Director Elias Zerhouni, M.D. "By using this new information we may be able to suppress chronic inflammation and reduce our Nation's cancer burden."

In the December 7, 2005 issue of the Journal of the National Cancer Institute, researchers at the National Institute of Environmental Health Sciences (NIEHS), a part of the National Institutes of Health, report that mice prone to lung cancer that had TLR4 removed or altered had 60 percent more tumors than mice that had intact receptors, illustrating a new protective role for this gene. There were no differences in overall tumor size or structure between the mice. TLR4 is part of what immunologists refer to as the "innate immune system" which acts as the body's first line of defense against harmful substances.

Researchers explain the immune system actually is comprised of two components or systems, the innate and the acquired. The innate system can be thought of as the way the body is naturally programmed to respond, forming the front line of defense against infection. The acquired depends on the development of antibodies and other systems to recognize pathogens and other foreign objects that might upset the body's ability to fight off diseases. Understanding more about how the innate system works will help inform how the more complex, acquired system works.

"We have recently learned a lot about TLR4, its different mutations, and the role they play in immunity," said David A. Schwartz, MD, the NIEHS Director, "but discovering this novel function of TLR4 in tumor biology may provide new therapeutic targets for many chronic diseases, including cancer."

"We can't
'"/>

Contact: Robin Mackar
rmackar@niehs.nih.gov
919-541-0073
NIH/National Institute of Environmental Health Sciences
7-Dec-2005


Page: 1 2

Related medicine news :

1. OFTs value-based pricing scheme is well-founded, but could increase overall NHS drug spend
2. Certain combination therapy found more effective for treating malaria in African children
3. Antifolate therapies found effective against certain type of malaria
4. High-quality child care for poor children found to offset the risk of later depression
5. No link found between autism and celiac disease
6. Correlation between bile duct obstruction and ductal cancer found
7. The root of dyscalculia found
8. Link found between teens stress levels and acne severity
9. CRP liver protein induces hypertension, UT Southwestern researchers have found
10. Link found between muscle damage during childbirth, condition causing fallen bladder, uterus
11. Grants from leading eye research foundation surpass $9M in 2006

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/5/2016)... ... May 05, 2016 , ... A ... found that more than 40 percent of participating fifth-grade students already have or ... Allergy and Asthma Clinical Research in the Division of Pulmonary, Allergy and Critical ...
(Date:5/5/2016)... ... 05, 2016 , ... In order to increase comfort, convenience ... a Seattle-based steam bath and sauna manufacturer recently launched amerecConnect™ , a ... the app, developed for both smartphones and personal computers perfectly emulates that of ...
(Date:5/5/2016)... , ... May 05, 2016 , ... United Collection Bureau, ... , Clark brings more than 15 years of experience within the healthcare revenue cycle ... successful career as the Director of Patient Financial Services at Spectrum Health. While at ...
(Date:5/5/2016)... (PRWEB) , ... May 05, 2016 , ... CURE ... with cancer, today announced a new collaboration with Imerman Angels to expand ... anywhere in the world. , “Imerman Angels provides an emotional lifeline to patients and ...
(Date:5/5/2016)... ... May 05, 2016 , ... Pigment Laser Tattoo Removal ... breakthrough technology of the new PiQo4™ laser, the first 4-wavelenth picosecond laser to receive ... than any other picosecond laser on the market. Jeremy Miller, Tattoo Artist and ...
Breaking Medicine News(10 mins):
(Date:5/5/2016)... Research and Markets has announced the ... the USA"  report to their offering.  ,     (Logo: ... current Positron Emission Tomography (PET) scanner and cyclotron install ... Along with the current known number of PET scanners ... the report also contains a detailed breakdown of this ...
(Date:5/5/2016)... 5, 2016 ... of the  "Europe Thrombocythemia Market and ... to their offering.       ... ,The latest research Europe Thrombocythemia Market ... provides comprehensive insights into Thrombocythemia pipeline ...
(Date:5/5/2016)... , May 5, 2016 ... addition of the  "Europe Thalassaemia Market and ... their offering.       (Logo: ... Europe Thalassaemia Market and Competitive Landscape Highlights ... pipeline products, Thalassaemia epidemiology, Thalassaemia market valuations ...
Breaking Medicine Technology:
Cached News: