Do not take ACTOS if you have active liver disease. Talk to your doctor immediately if you experience nausea, vomiting, stomach pain, tiredness, loss of appetite, dark urine, or yellowing of the skin. If you are of childbearing age, talk to your doctor before taking ACTOS as it could increase your chance of becoming pregnant. Some people taking ACTOS may experience flu-like symptoms, mild to moderate swelling of legs and ankles, and anemia. When taking ACTOS with insulin or sulfonylureas, you may be at risk for low blood glucose.

About glimepiride

Glimepiride is a prescription blood glucose-lowering drug of the sulfonylurea class. Side effects seen with glimepiride include hypoglycemia (blood glucose of <60 mg/dL), which may become more severe. Patients taking glimepiride should be aware of the signs and symptoms of hypoglycemia which may include shakiness, nervousness, sweating, hunger, headache, nausea, asthenia (loss of strength) and dizziness.

Glimepiride should not be taken by patients with hypersensitivity to the drug or with diabetic ketoacidosis. Glimepiride should be discontinued in nursing mothers. Administration of an oral hypoglycemic drug similar to glimepiride has been associated with increased cardiovascular mortality as compared to treatment with diet and exercise alone or diet plus insulin. Patients should always talk with their health professional about all the prescription and over-the-counter medications and dietary supplements they are taking before starting a new prescription.

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Contact: Amy Losak
amy.losak@ketchum.com
646-935-3917
Ketchum
30-Jun-2005