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Targeting the inflamed synovium

igns of the conventional side effects.

  • Further potential targets within the inflamed joint, including synovial macrophages, cells that work to remove harmful bacteria, and E-selectin, an adhesion molecule in the blood vessel walls that recruits immune-boosting lymphocytes.

    • Looking forward, Dr. Garrood and Dr. Pitzalis highlight substantial, indirect evidence of the existence of a truly specific synovial homing receptor "the key to unlocking the mechanisms of inflammation" and exciting advances in phage display technology. "Significant progress is being made in the development of technologies for specific targeting of the synovium and delivery of therapeutic agents," the authors attest. They conclude by emphasizing the importance of identifying novel molecular targets within the synovium for optimizing the diagnosis and management of RA.


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    Contact: Amy Molnar
    amolnar@wiley.com
    John Wiley & Sons, Inc.
    29-Mar-2006


    Page: 1 2

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