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Taste test may identify best drugs for depression

New research has shown that it might be possible to use taste as an indicator as to whether someone is depressed, and as a way of determining which is the most suitable drug to treat their depression.

Research from the University of Bristol has shown that our ability to recognise certain tastes can be improved by administering drugs usually given for depression.

The researchers gave healthy volunteers antidepressant drugs that increase levels of the neurotransmitters serotonin and noradrenaline. They report today in the Journal of Neuroscience that these tests resulted in the volunteers being able to detect different tastes (salt, sugar, sour, and bitter) at lower concentrations, thus enhancing their ability to taste.

Dr Lucy Donaldson, senior author on the paper, said: When we increased serotonin levels we found that people could recognise sweet and bitter taste at much lower concentrations than when their serotonin levels were normal. With increased noradrenaline levels the same people could recognise bitter and sour tastes at lower concentrations. Salt taste doesnt seem to be affected at all by altering either of these neurotransmitters.

She added: Because we have found that different tastes change in response to changes in the two different neurotransmitters, we hope that using a taste test in depressed people will tell us which neurotransmitter is affected in their illness.

Dr Jan Melichar, the lead psychiatrist on the paper, added: This is very exciting. Until now we have had no easy way of deciding which is the best medication for depression. As a result, we get it right about 60-80% of the time. It then takes up to four weeks to see if the drug is working, or if we need to change it. However, with a taste test, we may be able to get it right first time.

Taste is often thought to be determined genetically and, until now, people assumed it was fixed throughout life. But these studies show that the
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Contact: Cherry Lewis
cherry.lewis@bristol.ac.uk
44-117-928-8086
University of Bristol
5-Dec-2006


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