oS Clinical Trials are available to anyone to read and re-use for free, not only to researchers and practitioners but also to patients and trial participants. "The results of clinical trials belong in the public domain", says Steve Nissen, The Cleveland Clinic (Ohio, USA) and a member of the international Editorial Board of PLoS Clinical Trials. "I applaud the commitment of PLoS Clinical Trials to provide open access to randomized clinical trial reports so that investigators throughout the world can freely examine the results of these studies."

PLoS Clinical Trials has timed its launch to commemorate International Clinical Trials' Day (http://www.ecrin.org/ecrin_files/dokumente/International_clinical_trials_day_2006.pdf), with events taking place today in Brussels. PLoS Clinical Trials shares the goal with International Clinical Trials' Day of increasing clinical trials' awareness which ultimately leads to improved clinical practice.

The launch of PLoS Clinical Trials coincides with experts and funders of research worldwide proposing measures to ensure that the results of publicly-funded research, including clinical trials, are placed into the public domain. Current proposed US legislation mandates public access to federally-funded research no later than six months after publication. The Association of American Medical Colleges (http://www.aamc.org/) has presented principles for the responsible conduct and reporting of clinical trials, including the recommendation that positive, negative and null study findings always be published, preferably in peer-reviewed journals. The principles are presented in an essay in PLoS Clinical Trials by David Korn and Susan Ehringhaus (contact 1) :

Citation: Korn D, Ehringhaus S (2006). Principles for strengthening the integrity
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Contact: Andrew Hyde
press@plos.org
44-1-223-463-330
Public Library of Science
18-May-2006

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