Results are published in the June issue of Alcoholism: Clinical & Experimental Research.
We chose to examine leptin and ghrelin because both peptides are of high importance in appetite regulation and both have already been subject to former investigations, said Thomas Hillemacher, assistant professor in the department of psychiatry and psychotherapy at the University Hospital of Erlangen, Germany. However, these former investigations have shown contradictory results which may have been due to their use of samples of alcoholics without specifying subgroups. This raised the idea of investigating these peptides in specific subtypes of alcohol dependence. Hillemacher is also the corresponding author for the study.
There exist four different mechanisms of craving, which can lead to relapse, explained Otto Lesch, professor of psychiatry at the University of Vienna. We know that these four different mechanisms are caused by different biological mechanisms. They have different long-term courses and they profit significantly differently from different pharmaceutical compounds. Therefore, it is very important to define basic workings of these different