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The appetite-regulating peptide leptin influences alcohol craving for some alcoholics

re of great importance to alcohol research because they help to clarify that other studies results may be due to different selection criteria leading to different rates among subgroups.

Both Hillemacher and Lesch said that recognizing subgroups of alcoholics is imperative for future research as well as clinical applications.

Our findings show that there exist important differences between alcohol-dependent patients, not only regarding psychosocial but also regarding neurobiological influences, said Hillemacher.

Transmitter systems interact with peptides, and genetic research has to be aware that this interaction influences brain activities and therefore different mechanisms of craving, added Lesch. To explain addiction, we need mechanisms of different types of craving. Addiction is not caused by the drug, but is caused by biological and psychological vulnerabilities leading to different types of craving.


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24-May-2007


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