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The science behind a wrinkle-filler: Researchers discover for the first time how product works

ANN ARBOR, Mich. The current battle between the makers of anti-wrinkle products widely compared with the Coke and Pepsi struggle for superiority is receiving an injection of scientific understanding with the release of a new study from the University of Michigan Health System.

The study is the first to discover that one of the fillers known by the brand-name Restylane works by stretching fibroblasts, the cells in the skin that make collagen, in a way that causes the skin to create new collagen. This new, natural collagen then would contribute to the reduction of the appearance of creases and wrinkles. The study also shows that the product seems to inhibit the breakdown of existing collagen.

Prior to our research, it has been thought that Restylanes physical volume caused the improvement in the appearance of ones skin, says senior author John J. Voorhees, M.D., the Duncan and Ella Poth Distinguished Professor and chair of the Department of Dermatology at the U-M Medical School.

It is true that the physical presence of the product increases volume in the skin. Our research makes clear that injection of the product leads to creation of new collagen, which contributes to reduction in creases and wrinkles in a persons aging skin, Voorhees says.

The paper appears in the new issue of the journal Archives of Dermatology. Funding was provided by the U-M Department of Dermatology Cosmetic Research Fund, the Babcock Research Endowment at U-M and grants from the National Institutes of Health.

While Medicis Aesthetics provided the Restylane syringes used in the study, the company (which makes Restylane) had no involvement in the collection, management, analysis and interpretation of the data. The company also was not involved in the preparation or review of the manuscript.

Restylane has been in the news frequently in recent months, in part because of a competition between Medicis and Allergan Inc., the maker of
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Contact: Katie Gazella
kgazella@umich.edu
734-764-2220
University of Michigan Health System
19-Feb-2007


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