HOME >> MEDICINE >> NEWS
The 'upstairs/downstairs' mystery of cell suicide is burdened by too much evidence

The story of how mitochondria are recruited during times of stress to choreograph apoptosis--the cell's dance of death--is a story that fails to tell which particular set of steps the cells use most often, according to investigators at St. Jude Children's Research Hospital and the La Jolla Institute of Allergy and Immunology (San Diego, CA).

Mitochondria are sacs of enzymes in the cell that extract energy from food and store this energy in the high-powered chemical bonds of molecules called ATP. Virtually all activity of cells requires energy supplied by ATP, which acts as the "currency" with which the cell "buys" chemical reactions.

The fact that more than 100,000 research papers on apoptosis have been published is ironic, since this vast amount of information contributes to the confusion over which signaling pathways are most important for triggering this process, according to Douglas R. Green, Ph.D., chair of Immunology at St. Jude and holder of the Peter C. Doherty Endowed Chair of Immunology. Green is senior author of an editorial on apoptosis that appears in the October 7 issue of Science.

Apoptosis is the orderly process that both sculpts developing organisms out of a mass of replicating cells and disposes of irreparably damaged, mutated or infected cells. For example, cells that suffer DNA mutations that cannot be repaired undergo apoptosis to prevent them from forming a tumor.

Understanding the fine points of apoptosis is important to researchers seeking ways to control this process, Green said. Among the many therapeutic applications of such control would be triggering cancer cells to commit suicide. "But we can't design definitive treatments until we understand which pathways leading to apoptosis are the most important," Green said.

The major event in apoptosis is the breakdown of the membranes of the mitochondria. This breakdown allows certain proteins to spill out of the mitochondrion and help form a suicide switch called t
'"/>

Contact: Carrie Strehlau
Carrie.Strehlau@stjude.org
901-495-2295
St. Jude Children's Research Hospital
6-Oct-2005


Page: 1 2

Related medicine news :

1. UCLA, Italian chemists move closer to solving Lou Gehrigs disease mystery
2. Radiologists attempt to solve mystery of Tuts demise
3. Solution to bacterial mystery promises new drugs
4. St. Jude unlocks mystery of very aggressive leukemia
5. WA team uses baby tooth to solve death mystery
6. Old mystery solved, revealing origin of regulatory T cells that police and protect the body
7. New book explains age-old mystery of geometrical illusions
8. Differential heart-attack risks among blacks, whites remain mystery
9. Dating violence and sexual assault associated with suicide attempts among urban teens
10. Teens with migraine at greater risk of suicide
11. Did pack-size laws reduce paracetamol suicides or was fall just a coincidence?

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... Michigan (PRWEB) , ... June 26, 2016 , ... ... to fertility once they have been diagnosed with endometriosis. These women need a ... they also require a comprehensive approach that can help for preservation of fertility ...
(Date:6/25/2016)... , ... June 25, 2016 , ... "With 30 hand-drawn ... specific project," said Christina Austin - CEO of Pixel Film Studios. , ProHand ... all within Final Cut Pro X . Simply select a ProHand generator and ...
(Date:6/25/2016)... , ... June 25, 2016 , ... On Friday, June ... a Bronze Wellness at Work award to iHire in recognition of their exemplary accomplishments ... of the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle ... chronic pain and the benefits of holistic treatments, Serenity Recovery Center of ... Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the red ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all ... brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... India , June 24, 2016 ... Needles Market by Type (Standard Pen Needles, Safety Pen ... Therapy (Insulin, GLP-1, Growth Hormone), Mode of Purchase (Retail, ... by MarketsandMarkets, This report studies the market for the ... expected to reach USD 2.81 Billion by 2021 from ...
(Date:6/23/2016)... Research and Markets has announced the addition of the ... report to their offering. ... failure, it replaces the function of kidneys by removing the ... the treatment helps to keep the patient body,s electrolytes such ... Increasing number of ESRD patients & substantial healthcare expenditure on ...
(Date:6/23/2016)... , June 23, 2016 Research and ... Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data derived ... Assessment of major trends with potential impact on the market ... of market segmentation which comprises of sub markets, regional and ...
Breaking Medicine Technology:
Cached News: