HOME >> MEDICINE >> NEWS
The 'upstairs/downstairs' mystery of cell suicide is burdened by too much evidence

The story of how mitochondria are recruited during times of stress to choreograph apoptosis--the cell's dance of death--is a story that fails to tell which particular set of steps the cells use most often, according to investigators at St. Jude Children's Research Hospital and the La Jolla Institute of Allergy and Immunology (San Diego, CA).

Mitochondria are sacs of enzymes in the cell that extract energy from food and store this energy in the high-powered chemical bonds of molecules called ATP. Virtually all activity of cells requires energy supplied by ATP, which acts as the "currency" with which the cell "buys" chemical reactions.

The fact that more than 100,000 research papers on apoptosis have been published is ironic, since this vast amount of information contributes to the confusion over which signaling pathways are most important for triggering this process, according to Douglas R. Green, Ph.D., chair of Immunology at St. Jude and holder of the Peter C. Doherty Endowed Chair of Immunology. Green is senior author of an editorial on apoptosis that appears in the October 7 issue of Science.

Apoptosis is the orderly process that both sculpts developing organisms out of a mass of replicating cells and disposes of irreparably damaged, mutated or infected cells. For example, cells that suffer DNA mutations that cannot be repaired undergo apoptosis to prevent them from forming a tumor.

Understanding the fine points of apoptosis is important to researchers seeking ways to control this process, Green said. Among the many therapeutic applications of such control would be triggering cancer cells to commit suicide. "But we can't design definitive treatments until we understand which pathways leading to apoptosis are the most important," Green said.

The major event in apoptosis is the breakdown of the membranes of the mitochondria. This breakdown allows certain proteins to spill out of the mitochondrion and help form a suicide switch called t
'"/>

Contact: Carrie Strehlau
Carrie.Strehlau@stjude.org
901-495-2295
St. Jude Children's Research Hospital
6-Oct-2005


Page: 1 2

Related medicine news :

1. UCLA, Italian chemists move closer to solving Lou Gehrigs disease mystery
2. Radiologists attempt to solve mystery of Tuts demise
3. Solution to bacterial mystery promises new drugs
4. St. Jude unlocks mystery of very aggressive leukemia
5. WA team uses baby tooth to solve death mystery
6. Old mystery solved, revealing origin of regulatory T cells that police and protect the body
7. New book explains age-old mystery of geometrical illusions
8. Differential heart-attack risks among blacks, whites remain mystery
9. Dating violence and sexual assault associated with suicide attempts among urban teens
10. Teens with migraine at greater risk of suicide
11. Did pack-size laws reduce paracetamol suicides or was fall just a coincidence?

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/23/2020)... (PRWEB) , ... January 23, 2020 , ... ... IRF Executive Committee and the IRF Board of Trustees. Representing all segments of ... foundation in meeting its mission of conducting research and providing education highlighting the ...
(Date:1/23/2020)... ... January 23, 2020 , ... NowRx , the ... Orange County today with the grand opening of its state-of-the-art, 4,500 square foot, ... time of a traditional pharmacy. NowRx uses an eco-friendly fleet of delivery ...
(Date:1/22/2020)... (PRWEB) , ... January 22, ... ... that provides hearing, speech, and education services, recently appointed Ilana Glazer as ... communications, and outreach initiatives. Specifically, Ilana directs donor relations, grants administration, external ...
(Date:1/22/2020)... ... January 22, 2020 , ... Dr. Mario ... band can be for reducing food intake, enabling sustainable weight loss and improving ... while bariatric surgery may be a great tool for achieving significant weight loss, ...
(Date:1/12/2020)... ... January 11, 2020 , ... The co-founder and CEO of ... with the annual JP Morgan Healthcare Conference. On Sunday, January 12, Sujuan Ba, ... technology company investors and advisers at the San Francisco office of international law ...
Breaking Medicine News(10 mins):
(Date:1/24/2020)... ... January 24, 2020 , ... The American College of ... a systematic reform of the health care system. Recently, practicing internist and President of ... of Governmental Affairs and Public Policy at ACP, teamed with YourUpdateTV to discuss how ...
(Date:1/23/2020)... ... January 23, 2020 , ... ... assisted living community, has received a deficiency-free survey in 2019 as administered ... receive a deficiency-free survey from the State,” said Glen Cummins Regional Director of ...
(Date:1/23/2020)... ... January 23, 2020 , ... As Sarasota’s older population surges, ... want to stay in their own homes, according to The American Association of Retired ... care . Now, affluent seniors seeking truly professional caregivers have a new option -- ...
Breaking Medicine Technology:
Cached News: