HOME >> MEDICINE >> NEWS
The 'upstairs/downstairs' mystery of cell suicide is burdened by too much evidence

The story of how mitochondria are recruited during times of stress to choreograph apoptosis--the cell's dance of death--is a story that fails to tell which particular set of steps the cells use most often, according to investigators at St. Jude Children's Research Hospital and the La Jolla Institute of Allergy and Immunology (San Diego, CA).

Mitochondria are sacs of enzymes in the cell that extract energy from food and store this energy in the high-powered chemical bonds of molecules called ATP. Virtually all activity of cells requires energy supplied by ATP, which acts as the "currency" with which the cell "buys" chemical reactions.

The fact that more than 100,000 research papers on apoptosis have been published is ironic, since this vast amount of information contributes to the confusion over which signaling pathways are most important for triggering this process, according to Douglas R. Green, Ph.D., chair of Immunology at St. Jude and holder of the Peter C. Doherty Endowed Chair of Immunology. Green is senior author of an editorial on apoptosis that appears in the October 7 issue of Science.

Apoptosis is the orderly process that both sculpts developing organisms out of a mass of replicating cells and disposes of irreparably damaged, mutated or infected cells. For example, cells that suffer DNA mutations that cannot be repaired undergo apoptosis to prevent them from forming a tumor.

Understanding the fine points of apoptosis is important to researchers seeking ways to control this process, Green said. Among the many therapeutic applications of such control would be triggering cancer cells to commit suicide. "But we can't design definitive treatments until we understand which pathways leading to apoptosis are the most important," Green said.

The major event in apoptosis is the breakdown of the membranes of the mitochondria. This breakdown allows certain proteins to spill out of the mitochondrion and help form a suicide switch called t
'"/>

Contact: Carrie Strehlau
Carrie.Strehlau@stjude.org
901-495-2295
St. Jude Children's Research Hospital
6-Oct-2005


Page: 1 2

Related medicine news :

1. UCLA, Italian chemists move closer to solving Lou Gehrigs disease mystery
2. Radiologists attempt to solve mystery of Tuts demise
3. Solution to bacterial mystery promises new drugs
4. St. Jude unlocks mystery of very aggressive leukemia
5. WA team uses baby tooth to solve death mystery
6. Old mystery solved, revealing origin of regulatory T cells that police and protect the body
7. New book explains age-old mystery of geometrical illusions
8. Differential heart-attack risks among blacks, whites remain mystery
9. Dating violence and sexual assault associated with suicide attempts among urban teens
10. Teens with migraine at greater risk of suicide
11. Did pack-size laws reduce paracetamol suicides or was fall just a coincidence?

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/3/2016)... CA (PRWEB) , ... May 03, 2016 , ... ... is a process that selects DNA or RNA from a random library of ... potentially be used as drugs or diagnostic agents. SELEX selection is commonly performed ...
(Date:5/3/2016)... ... May 03, 2016 , ... ... creative director Joe Ferrazano to serve in the newly created position of executive ... overseeing the agency’s creative efforts in the Chicago and LA offices. He reports ...
(Date:5/3/2016)... ... , ... Elizabeth Murray has always loved walking one to two miles a ... shoulder and one on her arm. But she got to the point where she ... prolapse. , The valves of the heart wouldn’t close properly resulting in mitral regurgitation, ...
(Date:5/3/2016)... (PRWEB) , ... May 03, 2016 , ... Excessive panting ... signs of pet anxiety. "Pet owners often think anxiety only manifests itself as ... signals in other ways, and there’s things that be done about it,” says Dr. ...
(Date:5/3/2016)... ... May 03, 2016 , ... Diagnotes, a ... Tidelands Health, a three hospital system in South Carolina, to provide its secure ... for technology that enhances communication, drives workflow efficiencies and improves provider and patient ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... PUNE, India , May 3, 2016 /PRNewswire/ ... Market 2016 Research Report provides a basic overview ... manufacturing technology, post which the surgical mesh report ... the market. Complete report on Surgical ... company profiles and 98 tables and figures is ...
(Date:5/2/2016)... 2016  While nearly three-quarters of Americans (71%) are ... their health, only about half report taking any steps ... of a new survey announced today by Hologic (Nasdaq: ... National Osteoporosis Month, Hologic is raising awareness of this ... million Americans. Osteoporosis is a disease that ...
(Date:4/29/2016)... 29, 2016 Acquisition Expands ... Product Development Capabilities in North America ... . Indegene ( http://www.indegene.com ), ... acquisition of Skura Corporation,s life science business. Skura,s ... sales enablement technology for life science organizations and ...
Breaking Medicine Technology:
Cached News: