HOME >> MEDICINE >> NEWS
The 'upstairs/downstairs' mystery of cell suicide is burdened by too much evidence

The story of how mitochondria are recruited during times of stress to choreograph apoptosis--the cell's dance of death--is a story that fails to tell which particular set of steps the cells use most often, according to investigators at St. Jude Children's Research Hospital and the La Jolla Institute of Allergy and Immunology (San Diego, CA).

Mitochondria are sacs of enzymes in the cell that extract energy from food and store this energy in the high-powered chemical bonds of molecules called ATP. Virtually all activity of cells requires energy supplied by ATP, which acts as the "currency" with which the cell "buys" chemical reactions.

The fact that more than 100,000 research papers on apoptosis have been published is ironic, since this vast amount of information contributes to the confusion over which signaling pathways are most important for triggering this process, according to Douglas R. Green, Ph.D., chair of Immunology at St. Jude and holder of the Peter C. Doherty Endowed Chair of Immunology. Green is senior author of an editorial on apoptosis that appears in the October 7 issue of Science.

Apoptosis is the orderly process that both sculpts developing organisms out of a mass of replicating cells and disposes of irreparably damaged, mutated or infected cells. For example, cells that suffer DNA mutations that cannot be repaired undergo apoptosis to prevent them from forming a tumor.

Understanding the fine points of apoptosis is important to researchers seeking ways to control this process, Green said. Among the many therapeutic applications of such control would be triggering cancer cells to commit suicide. "But we can't design definitive treatments until we understand which pathways leading to apoptosis are the most important," Green said.

The major event in apoptosis is the breakdown of the membranes of the mitochondria. This breakdown allows certain proteins to spill out of the mitochondrion and help form a suicide switch called t
'"/>

Contact: Carrie Strehlau
Carrie.Strehlau@stjude.org
901-495-2295
St. Jude Children's Research Hospital
6-Oct-2005


Page: 1 2

Related medicine news :

1. UCLA, Italian chemists move closer to solving Lou Gehrigs disease mystery
2. Radiologists attempt to solve mystery of Tuts demise
3. Solution to bacterial mystery promises new drugs
4. St. Jude unlocks mystery of very aggressive leukemia
5. WA team uses baby tooth to solve death mystery
6. Old mystery solved, revealing origin of regulatory T cells that police and protect the body
7. New book explains age-old mystery of geometrical illusions
8. Differential heart-attack risks among blacks, whites remain mystery
9. Dating violence and sexual assault associated with suicide attempts among urban teens
10. Teens with migraine at greater risk of suicide
11. Did pack-size laws reduce paracetamol suicides or was fall just a coincidence?

Post Your Comments:
(Date:7/28/2014)... HealthDay Reporter MONDAY, July 28, ... milliseconds to look at someone,s face and judge them good-looking ... certain facial features seem to trigger specific first impressions about ... the mouth, for example, appear directly linked to whether someone ... The study findings suggest that first impressions are fairly ...
(Date:7/28/2014)... Nashville, TN (PRWEB) July 28, 2014 ... successful Operation Military June . Renowned LASIK ... Military June" to provide significant funds and public ... active and retired military personnel and their families. ... we will proudly give nearly $5,000 to a ...
(Date:7/28/2014)... News) --,The more chronic medical conditions people have at ... a new study claims. Since nearly four ... at Johns Hopkins Bloomberg School of Public Health in ... in life expectancy are slowing in the United States. ... kidney disease and heart failure is now the norm ...
(Date:7/28/2014)... 28, 2014 SIMpalm helped its ... App is available on iTunes for download . Experience ... Audio Chef allows you to listen and cook along with ... way: simply get out the ingredients and equipment, press play, ... or prepare ingredients ahead of time, just relax and cook ...
(Date:7/28/2014)... Lake City, Utah (PRWEB) July 28, 2014 ... protein powders and drinks, announced that it will be ... drink line of products this summer. The additional flavors ... with clean pure taste-free protein , Inspire Pomegranate Razz ... Vanilla - flavor of soft-serve vanilla cone , Bariatric ...
Breaking Medicine News(10 mins):Health News:Facial Dimensions May Be Key to First Impressions 2Health News:Facial Dimensions May Be Key to First Impressions 3Health News:Shofner Vision Center’s “Operation Military June” Provided Funds For Local Not-For-Profit Organizations Supporting Military And Their Families 2Health News:Shofner Vision Center’s “Operation Military June” Provided Funds For Local Not-For-Profit Organizations Supporting Military And Their Families 3Health News:Chronic Medical Conditions Can Shorten Seniors' Lives: Study 2Health News:Audio Chef Co. Releases Audio Cooking App for iPhone/iPad/iPod touch 2Health News:Audio Chef Co. Releases Audio Cooking App for iPhone/iPad/iPod touch 3Health News:Audio Chef Co. Releases Audio Cooking App for iPhone/iPad/iPod touch 4Health News:Bariatric Eating Announces Three New Protein Shake Flavors 2
(Date:7/28/2014)... Pharmacyclics, Inc. (the "Company") (Nasdaq: PCYC ) today ... webcast to discuss financial results for the second quarter of ... 2014 at 4:30 p.m. ET. Conference call ... 2014 Time: 4:30 PM ET Listen via Internet: http://ir.pharmacyclics.com/events.cfm ... A webcast replay will be available on the Pharmacyclics website ...
(Date:7/28/2014)... , July 28, 2014  Dignity Health ... has received the Get With The Guidelines®-Stroke Silver-Plus ... measures outlined by the American Heart Association/American Stroke ... is the number four cause of death and ... the United States , according to ...
(Date:7/28/2014)... Pharmaceuticals, Inc. (NASDAQ: ANTH ), today announced financial ... 30, 2014. Net loss for the three ... $8.3 million for the same period in 2013. The decrease ... in interest expense in the current period.  ... was $15.2 million, compared with net loss of $15.9 million ...
Breaking Medicine Technology:Pharmacyclics Announces Date of Conference call to discuss Financial Results for Second Quarter of 2014 2Dignity Health St. Mary's Medical Center Honored with Quality Achievement Award for Stroke Care 2Dignity Health St. Mary's Medical Center Honored with Quality Achievement Award for Stroke Care 3Anthera Pharmaceuticals Reports 2014 Second Quarter Financial Results and Operational Update 2Anthera Pharmaceuticals Reports 2014 Second Quarter Financial Results and Operational Update 3Anthera Pharmaceuticals Reports 2014 Second Quarter Financial Results and Operational Update 4Anthera Pharmaceuticals Reports 2014 Second Quarter Financial Results and Operational Update 5Anthera Pharmaceuticals Reports 2014 Second Quarter Financial Results and Operational Update 6Anthera Pharmaceuticals Reports 2014 Second Quarter Financial Results and Operational Update 7
Cached News: