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The 'upstairs/downstairs' mystery of cell suicide is burdened by too much evidence

he apoptosome. Some of the critical steps in apoptosis occur before that breakdown of the mitochondria, that is, "upstairs" from the mitochondria, Green said. The other critical steps occur after, or "downstairs" from the mitochondria, he added.

"Based on all the information available, you could conclude that an enormous number of molecules and pathways trigger apoptosis," Green noted. "So we need to identify the most important series of steps in this process. Otherwise we might concentrate too much of our attention on relatively unimportant byways on the road to apoptosis and miss the major highways."


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Contact: Carrie Strehlau
Carrie.Strehlau@stjude.org
901-495-2295
St. Jude Children's Research Hospital
6-Oct-2005


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