HOME >> MEDICINE >> NEWS
Therapeutic unshackles p53 and causes tumor regression

Infection with Kaposi's sarcoma virus (KSHV) can cause 3 types of tumor, including primary effusion lymphoma (PEL). Although KSHV has been known to cause tumors for many years, there are no effective therapies for the treatment of KSHV-induced tumors. Now, researchers from the University of Helsinki, Finland, have found that the small-molecule inhibitor Nutlin-3a has antitumor effects in a mouse xenograft model of PEL.

In the study, which appears online on March 15 in advance of publication in the April print issue of the Journal of Clinical Investigation, Pivi Ojala and colleagues show that Nutlin-3a induces human PEL cell lines to undergo cell death by a process known as apoptosis. Nutlin-3a was found to disrupt an interaction between the KSHV protein LANA and the human proteins p53 and MDM2, releasing p53 to mediate apoptosis. As treatment with Nutlin-3a induced substantial tumor regression in mice with established human PEL, reactivation of p53 using Nutlin-3a might provide a viable therapeutic for the treatment of individuals with PEL.


'"/>

Contact: Karen Honey
press_releases@the-jci.org
212-342-4159
Journal of Clinical Investigation
15-Mar-2007


Page: 1

Related medicine news :

1. Tibotec Therapeutics announces start of largest US study on HIV treatment in women
2. Therapeutic role found for carbon monoxide
3. Therapeutic communities: A three country comparison
4. Therapeutic prospects beyond Vioxx
5. Therapeutic vaccine for ovarian cancer in clinical trials
6. Investigating the causes of Parkinsons disease
7. QBI scientist looks at why stroke causes vision problems
8. Hexavalent chromium in drinking water causes cancer in lab animals
9. Panel offers expert analysis on causes, prevention of stent thrombosis
10. New treatment for fungus which causes thrush and sepsis
11. Weak immune response critical to disease that causes most infant hospitalizations

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/19/2019)... ... April 19, 2019 , ... According to the Environmental ... alone comes with pesticide residue. Pesticides are sprayed on produce to repel insects, but ... what make up that thin, waxy layer that covers the skin of most produce ...
(Date:4/19/2019)... VEGAS (PRWEB) , ... April 19, 2019 , ... ... dental practices specializing in surgical and prosthetic implant dentistry, will host a free ... The seminar will provide attendees with valuable information related to dental implants, including; ...
(Date:4/19/2019)... ... 18, 2019 , ... Residents in long-term-care nursing facilities were prescribed fewer medications ... according to a study of U.S. men and women led by the staff ... Research Institute (BRI) . The quality assurance study examined the high number of prescriptions ...
(Date:4/19/2019)... ... April 19, 2019 , ... ... of health- and eco-friendly foodservice brands. From plant-based proteins to herbal tonics, gluten-free ... foodservice market., , • Field Roast, a Seattle-based company, ...
(Date:4/18/2019)... N.J. (PRWEB) , ... April 18, 2019 , ... ... announced a number of workshop presentations at the upcoming Global Clinical Supplies Group ... Spa, San Antonio, Texas, on April 28 – May 1, 2019. , Erin ...
Breaking Medicine News(10 mins):
(Date:4/18/2019)... (PRWEB) , ... April 18, 2019 , ... ... assist the life science industry in advancing the development of medical therapies, announced ... liver disease (NAFLD) and its more advanced form, nonalcoholic steatohepatitis (NASH), to help ...
(Date:4/18/2019)... ... April 18, 2019 , ... ... launch of its industry-leading OPTIMASE® portfolio of biobased enzymes for medical instrument ... unique needs and specific challenges faced by medical instrument cleaning customers,” said ...
(Date:4/17/2019)... ... ... do you feel overwhelmed by all of the decisions you make when it comes to ... your employees? Do you have the budget for a best in class solution? Will the ... of Strategic Partnerships, Hodges-Mace and Jay Schmitt, Principal, Strategic Benefits Advisors , ...
Breaking Medicine Technology:
Cached News: