Toward the future of cancer prevention

er risk of developing bladder cancer. Folate is crucial to DNA synthesis and repair, and cigarette smoking (the major cause of the disease) puts this system under stress, the researchers say. The same genes that are implicated in cancer risk also may be involved in prediction of patient outcome, Spitz says. Among recent discoveries are that:
  • Patients with esophageal cancer who had the best treatment outcomes were those that had gene variants that were less effective at neutralizing the killing power of cancer treatments. For example, patients treated with radiation treatment, who inherited less-effective variants of a gene (XRCC1) that repairs DNA damage from radiation, exhibited longer survival.
  • People with more efficient DNA repair function who were given chemotherapy, particularly platinum-based drugs like cisplatin, had a lower overall survival rate than those with less efficient DNA repair.

While faulty DNA repair genes may put a person at risk for developing cancer, they also may benefit them when that cancer is being treated, Spitz says. "Such detailed genetic information can help us develop targeted interventions depending upon individual risk, which will promote cancer prevention and earlier detection as well as improve patient treatment and outcome."

Currently, researchers in the Department of Epidemiology are studying more than 3,000 patients diagnosed with lung, head and neck, bladder, kidney or esophageal cancer. Similar approaches are ongoing for other cancers including melanoma, glioma, lymphoma, and breast and prostate cancer. They ask these patients questions relating to their smoking status, diet, occupation, exposure to chemicals and family history, and then collect urine, blood and tissue cells.

From these samples, they are applying novel molecular "assays," or tests that gauge the biological importance of various genes or proteins.

Among the molecules being i

Contact: Nancy Jensen
University of Texas M. D. Anderson Cancer Center

Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19

Related medicine news :

1. NIH scientists target future pandemic strains of H5N1 avian influenza
2. The Eli and Edythe Broad Foundation invests in gastroenterologys future
3. The future of biofuels is not in corn
4. The future of biofuels is not in corn
5. Inactive kids storing up illness for the future
6. SCAIs Therapies in Evolution showcases exciting future of interventional cardiology
7. Conception date affects babys future academic achievement
8. ASU, Walter Reed researchers create prosthesis of the future
9. Why GNEP cant jump to the future
10. NeuroArm: Navigating the future of surgery
11. IceSAR campaign provides glimpse of future Sentinel-1 images over ice

Post Your Comments:

(Date:6/27/2016)... ... June 27, 2016 , ... ... professionals, announced today its affiliation with Tennessee Counseling Association. This new ... network of the Tennessee Counseling Association, adding exclusive benefits and promotional offers. , ...
(Date:6/27/2016)... ... 2016 , ... A revolution is underway. Brooklyn-based company, ... for the millions of people who require these medical transport services annually. ... the use of technology. Now, SmartEMS has put forth an industry-changing app that ...
(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating in cancer care, and ... in the eye of the beholder, according to experts who offered insights and commentary ... of Managed Care. For the full issue, click here . , For the ...
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ... , "Film editors can give their videos a whole new perspective by using the ... CEO of Pixel Film Studios. , ProSlice Levels contains over 30 Different presets ...
(Date:6/26/2016)... ... ... blind and certified personal trainer is helping to develop a weight loss fitness plan that ... the two major problems leading the fitness industry today:, , All ... They don’t eliminate all the reasons people quit their exercise program , ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... 2016 Story Highlights: ... within the health care industry is causing providers to ... , Deloitte offers a suite of solutions for health ... efficient cost optimization: labor resource analysis, revenue cycle optimization ... better outcomes and better economics ...
(Date:6/24/2016)... SAN FRANCISCO, Calif. , June 24, 2016 ... GBT ), a biopharmaceutical company developing novel therapeutics ... significant unmet needs, today announced the closing of ... shares of common stock, at the public offering ... shares in the offering were offered by GBT. ...
(Date:6/24/2016)... -- Research and Markets has announced ... Applications, Technologies, Forecasts" report to their offering. ... Smart Skin, Structural Health Monitoring, Composite Smart Structures, ... involves electronic and/or electrical components and circuits that ... such as vehicle bodies or conformally placed upon ...
Breaking Medicine Technology:
Cached News: