HOME >> MEDICINE >> NEWS
Transplanting human gut bugs into mice helps understanding of metabolic system

Bugs found in the guts of humans, which play an important part in peoples metabolic makeup, have been transplanted into mice to further understanding of the human and animal metabolic system, reveals a new study in the journal Molecular Systems Biology.

Bugs in the gut are known as gut microbes and they live symbiotically in human and animal bodies. The new study involved understanding the major role that gut microbes have in determining how the body absorbs fat and digests fibre, and their effects on metabolic pathways in the body. The researchers, from Imperial College London and Nestl Research Center, Lausanne, Switzerland, found that microbes affect the way fats are absorbed and metabolised, by affecting bile acids. Bile acids are made by the liver to allow emulsification of fats in the upper gut. The researchers found that gut microbes can change how effective this emulsification process is because they metabolise bile acids.

The bile acids are also hormonal regulators which change the way fat is processed in the liver, so changes made by gut microbes to bile acid metabolism can affect this internal process.

The scientists also explored how microbes break down fibre in the lower gut. Certain microbes allow dietary fibre to be digested and the more effective these microbes are, the more calories are absorbed from the diet.

Different people have different types of gut microbes living inside them and abnormalities in some types have recently been linked to diseases such as diabetes and obesity. The scientists believe that transplanting the bugs found in humans into mice will enable better understanding of gut microbes effects, good and bad, and help them to develop better treatments (including probiotics and functional foods) for a wide range of conditions.

Professor Jeremy Nicholson, one of the lead authors of the paper from the Department of Biomolecular Medicine at Imperial College London, said: "Humans
'"/>

Contact: Laura Gallagher
L.Gallagher@imperial.ac.uk
44-020-759-46702
Imperial College London
21-May-2007


Page: 1 2

Related medicine news :

1. Transplanting organs from animals to humans -- what are the barriers?
2. Transplanting kidneys which have stones poses little risk to organs viability
3. New research discovers independent brain networks control human walking
4. UD scientists invent novel hydrogels for repairing, regenerating human tissue
5. Report calls for new directions, innovative approaches in testing chemicals for toxicity to humans
6. Stanford researchers track human stem cells transplanted into rat brain
7. Medicalizing the human condition
8. Vaxfectin-formulated measles DNA vaccine elicits long-term protection in nonhuman primates
9. Tests show healthy humans not harmed by Taser
10. Testing the taser on human subjects -- preliminary physiological measurements
11. Pioneering study maps attention, memory and language links in the human brain

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/8/2019)... Conn. (PRWEB) , ... October 08, 2019 , ... ... centers, recently acquired a majority interest in Advanced Fertility Care (AFC), an advanced ... are joining forces to expand the availability of RE services to expectant families ...
(Date:10/8/2019)... WASHINGTON (PRWEB) , ... October 08, 2019 , ... ... development and support services for the Department of Veterans Affairs Community Care Referrals ... continue its implementation of the VA’s Health Share Referral Manager (HSRM), an enterprise-wide ...
(Date:10/8/2019)... ... 08, 2019 , ... As a world-renowned expert using intravital ... with the University of Maryland Department of Veterinary Medicine, continues to make new ... and his lab have discovered a new pathway by which liver macrophages called ...
(Date:10/8/2019)... , ... October 08, 2019 , ... Over the past ... as a standout in the sports restaurant category by providing a higher-quality product and ... new fall menu as well as a "RAISE A MUG FOR THE CAUSE" campaign ...
(Date:10/8/2019)... ... ... METAvivor Research and Support Inc., a non-profit organization dedicated to funding research ... campaign. The campaign will commence with two days of action and education on October ... a march, a Die-In (hosted by partner MET-UP), and visits with Congressional offices. The ...
Breaking Medicine News(10 mins):
(Date:10/11/2019)... ... ... Based on data for the first eight months of the year, 2019 ... 2018. Through August 31, 7,786 deceased donors have provided 23,797 organs for transplant according ... pace, the Association of Organ Procurement Organizations (AOPO) projects 2019 could see an additional ...
(Date:10/10/2019)... ... October 10, 2019 , ... Hospice of Westchester (HOW) recently ... at the Westchester Country Club in Rye. The event honored Grassy Sprain Pharmacy, ... its mission. , “In Celebration” featured live entertainment, culinary delights and a fabulous ...
(Date:10/8/2019)... ... October 09, 2019 , ... “When Seconds Count: Reports From an ... realities of the HEMS world through telling the real stories of the EMS flight ... of published author Jay A. Humphrey, an EMS helicopter pilot. He has been a ...
Breaking Medicine Technology:
Cached News: