Treatment of in-hospital cardiac patients is focus of Jefferson University presentations

beta blocker regimen when hospitalized, should weigh the benefits of reducing or stopping the beta blocker. Those patients whose initial inpatient beta blocker dose was reduced or stopped had a significantly increased LOS suggesting that it may be detrimental to decrease outpatient beta blocker dosage upon hospitalization for ADHF.

Members of the team who conducted this study at Thomas Jefferson University in Philadelphia, Pa., are:

Saum Shamimi-Noori, M.D.,

David Whellan, M.D.,

Abhijit Dasgupta, Ph.D,

Suzanne Adams, CRN,

Paul Mather, M.D.,

Sharon Rubin, M.D.,

Jocelyn Andrel and

Arthur Feldman, M.D., Ph.D.

Extracellular Matrix Protein, Fibulin-2, Enhances Acute Wound Healing After Experimental Myocardial Infarction in Mice
(Embargoed for release 10 am, Tuesday, March 27; Abstract #1025-75)

After surviving a heart attack, a big issue for a patient is the healing of the wound. Researchers at Thomas Jefferson University and Alfred I. DuPont Hospital for Children have found something that may help; theyve identified a protein that contributes to the wound healing process after a heart attack.

The researchers will present the study at the American College of Cardiologys 56th Annual Scientific Session in New Orleans on March 27 at 10 am (abstract 1025-75).

They used mice to examine the role of Fibulin-2, an extracellular matrix protein, to better understand its role in wound repair. Fibulin-2 is naturally occurring in embryonic development as well as in tissue remodeling after various injuries.

Extracellular matrix, which embraces and connects cells within the tissue, may provide structural integrity during tissue remodeling after injury, but little is known about its functional aspects.

By comparing the results of heart attacks in mice that did not have the Fibulin-2 protein with normal mice at both 24 and 72 hours after the heart attack, the re

Contact: Nan Myers
Thomas Jefferson University

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