searchers found that acute wound healing was significantly delayed in the mice lacking Fibulin-2. After 72 hours, they found that the damaged (infarct) area was much larger in the mice lacking Fibulin-2.
The researchers found that the wound healing process was much slower in the mice lacking Fibulin-2 after a heart attack due to delayed scar tissue formation in the damaged area. The study demonstrated that Fibulin-2 facilitates heart wound healing probably with the help of (TGF)-?, a growth factor that promotes wound healing.
The researchers are also currently looking into the role of Fibulin-2 as a factor in the development of chronic heart failure.
Members of the team who conducted this study at Thomas Jefferson University in Philadelphia, Pa., and Alfred I DuPont Hospital for Children in Wilmington, Del., are:
Takeshi Tsuda, M.D.;
Erhe Gao, M.D., Ph.D.;
Francois X. Sicot, Ph.D.;
Hailong Dong, M.D., Ph.D.;
Dessislava Markova, Ph.D.,
Xinliang Ma, M.D., Ph.D. and
Mon-Li Chu, Ph.D.
'"/>Contact: Nan Myers
nan.myers@jefferson.edu
215-955-6300
Thomas Jefferson University 27-Mar-2007Page: 1 2 3 4 Related medicine news :1.
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