HOME >> MEDICINE >> NEWS
U of M researchers discover new method to combat HIV

MINNEAPOLIS / ST. PAUL (July 23, 2007) Researchers at the University of Minnesotas Center for Drug Design have developed a new method to combat HIV/AIDS, potentially replacing the traditional cocktail drug approach.

The new approach proven accurate in lab tests merges the features of two antiviral agents into one drug, achieving the same effect as when two or more drugs are taken separately. The cocktail approach most commonly prescribed to HIV-infected patients is expensive and high in toxicity because many drugs are taken at one time.

The researchers named the new concept Portmanteau Inhibitors, and the results were published in a July 4 issue of the Journal of Medicinal Chemistry. The principal researcher is Robert Vince, Ph.D., director of the center and a professor of medicinal chemistry in the College of Pharmacy.

Its one drug that does the same thing as two independent drugs would do, Vince said. Its a new approach in HIV/AIDS treatment.

Besides remedying cost and toxicity problems, a Portmanteau Inhibitor is less likely to develop resistance from the virus because of its multifaceted approach. Most importantly, research found that the separate components of the drug did not interfere with each other while attacking HIV.

One drug is not durable. It develops resistance very quickly, said Zhenqiang Wang, Ph.D., a researcher in the Center for Drug Design, and co-investigator of the research. This makes it much more difficult for resistance to develop.

The next step will be more research and testing to see how the drug reacts once distributed in the body. But, preliminary research and confirmation of the new concept shows promise because the quality of life for AIDS patients hinges on low costing medication and minimal side effects, Wang said.

Its huge, he said. This concept could lead to a replacement for the cocktail treatment.


'"/>

Contact: Nick Hanson
hans2853@umn.edu
612-624-2449
University of Minnesota
23-Jul-2007


Page: 1

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers awarded $9M contract for study identifiying antibiotic treatment for MRSA
3. Penn researchers discover novel pathway for increasing good cholesterol
4. Theory of facial aging gets a facelift from UT Southwestern researchers
5. UIC researchers to develop new drugs to fight bioterrorism
6. UQ researchers discover some of the oldest forms of life
7. U of M researchers assess effectiveness of computerized physician order entry system
8. Nepalese researchers identify cost-effective treatment for drug-resistant typhoid
9. Physician-researchers often less successful in obtaining NIH funding
10. UCLA researchers develop new nanomaterials to deliver anti-cancer drugs to cells
11. Cedars-Sinai researchers present new endocrine findings at 2 international conferences

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/5/2019)... ... December 05, 2019 , ... Abide, the #1 Christian meditation ... times this year using Bible-based bedtime stories. Listeners have recovered from bad dreams and ... the Center for Disease Control, one third of Americans suffer from poor sleep, which ...
(Date:12/5/2019)... (PRWEB) , ... December 05, 2019 , ... ... with milestones ranging from launching exceptional products that help people embrace, achieve, and ... world. , “We’ve never been more committed to our mission of impacting world ...
(Date:12/4/2019)... CARDIFF BY THE SEA, Calif. (PRWEB) , ... ... ... Prickly Pear fruit, trademarked as Tex-OE, Opuntia Mesocarp Extract®, provides protection from disruptions ... amazing extract, effective at countering the menace of Jet Lag, is available in ...
(Date:12/4/2019)... STATION, Texas (PRWEB) , ... December 04, 2019 , ... ... a time of physical and mental stress, said Texas A&M AgriLife Extension Service specialists. ... during the holidays to lower stress and benefit your overall wellness,” said Joyce Cavanagh, ...
(Date:12/2/2019)... , ... December 02, 2019 , ... More than $400 ... midnight on December 31. While many people spend their tax-free funds throughout the year, ... on New Year’s Eve. In an effort to help account holders use -- not ...
Breaking Medicine News(10 mins):
(Date:12/6/2019)... ... December 06, 2019 , ... Plant Life Company announced ... LLC (a division of Horticultural Holdings LLC) to recommend Plant Life Company’s line ... FFGS is a team of disciplined and energetic plant lovers formally educated in ...
(Date:12/4/2019)... , ... December 04, 2019 , ... The Harm Reduction ... an Orange County drug and alcohol rehab center and non-profit Intensive ... their team conducted street outreach, trained, and distributed Naloxone amongst members of the own ...
(Date:12/2/2019)... ... December 02, 2019 , ... A Better ... Michael, an intensive mental health facility, announced it has named Tim Ryan and ... development and national advocacy efforts. , "We are proud to announce that Jennifer ...
Breaking Medicine Technology:
Cached News: