HOME >> MEDICINE >> NEWS
UCLA researchers develop new nanomaterials to deliver anti-cancer drugs to cells

Researchers at UCLA have successfully manipulated nanomaterials to create a new drug-delivery system that promises to solve the challenge of the poor water solubility of todays most promising anticancer drugs and thereby increase their effectiveness.

The poor solubility of anticancer drugs is one of the major problems in cancer therapy because the drugs require the addition of solvents in order to be easily absorbed into cancer cells. Unfortunately, these solvents not only dilute the potency of the drugs but create toxicity as well.

In a paper scheduled to be published in the nanoscience journal Small in June, researchers from UCLAs California NanoSystems Institute and Jonsson Cancer Center report a novel approach using silica-based nanoparticles to deliver the anticancer drug camptothecin and other water-insoluble drugs into human cancer cells.

The study is led by Fuyu Tamanoi, UCLA professor of microbiology, immunology and molecular genetics and director of the Jonsson Cancer Centers Signal Transduction and Therapeutics Program Area, and Jeffrey Zink, UCLA professor of chemistry and biochemistry.

Tamanoi and Zink devised a method for incorporating the representative hydrophobic anticancer drug camptothecin into the pores of fluorescent mesoporous silica nanoparticles and delivering the particles into a variety of human cancer cells to induce cell death. The results suggest that the mesoporous silica nanoparticles might be used as a vehicle to overcome the insolubility problem of many anticancer drugs.

Silica nanomaterials show promise for delivering camptothecin and other water-insoluble drugs, Tamanoi said. We have successfully loaded hydrophobic anticancer drugs into mesoporous nanoparticles and delivered them into human cancer cells to induce cell death.

The beauty of our findings is that these nanoparticles are biocompatible, contain tubular pores and are relatively easy to modify, Zink said. A
'"/>

Contact: Jennifer Marcus
jmarcus@cnsi.ucla.edu
310-267-4839
University of California - Los Angeles
6-Jun-2007


Page: 1 2

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers awarded $9M contract for study identifiying antibiotic treatment for MRSA
3. Penn researchers discover novel pathway for increasing good cholesterol
4. Theory of facial aging gets a facelift from UT Southwestern researchers
5. UIC researchers to develop new drugs to fight bioterrorism
6. UQ researchers discover some of the oldest forms of life
7. U of M researchers discover new method to combat HIV
8. U of M researchers assess effectiveness of computerized physician order entry system
9. Nepalese researchers identify cost-effective treatment for drug-resistant typhoid
10. Physician-researchers often less successful in obtaining NIH funding
11. Cedars-Sinai researchers present new endocrine findings at 2 international conferences

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/23/2019)... ... July 23, 2019 , ... The National Oncology State Network ... Partners representing: Alabama, Alaska, California, Connecticut, Georgia, Hawaii, Illinois, Maryland, Michigan, Mississippi, New ... review of NOSN’s 2018 accomplishments starting with the status of Cancer Caucuses in ...
(Date:7/19/2019)... ... July 19, 2019 , ... Juvly Aesthetics has announced an ... Director of Marketing and Sales. In his role, Okuley will be leading the ... while furthering the company’s mission of empowering clients to look and feel their ...
(Date:7/18/2019)... , ... July 18, 2019 , ... LEAD Hospitality Group ... organized by the Epilepsy Foundation of Georgia. The event is scheduled to take place ... Building 4 at Concourse Parkway, right under the King & Queen Buildings. LEAD Hospitality ...
(Date:7/17/2019)... ... July 17, 2019 , ... ... first that is capable of treating up to eight body areas simultaneously. Dr. ... body muscle toning much faster and easier than previous muscle toning devices or conventional exercise. ...
(Date:7/17/2019)... ... July 17, 2019 , ... Becker's Healthcare is pleased to ... The men and women included on this list lead organizations regularly recognized for ... as well as the construction of satellite clinics and strategic partnerships with local ...
Breaking Medicine News(10 mins):
(Date:7/18/2019)... ... July 18, 2019 , ... Joining PAINWeek, ... be presenting two 2-hour courses on Saturday, September 7. PAINWeek faculty members James ... MD, an IMS Board Member and Pain Specialist, will lead these skills training ...
(Date:7/18/2019)... United Kingdom and MALVERN, Pa. (PRWEB) , ... ... ... series of complimentary seminars aimed at helping pharmaceutical companies reach meeting regulatory guidelines ... What Rules & Regulations are Doing for TMF Health, Phlexglobal will host two ...
(Date:7/17/2019)... ... 17, 2019 , ... Chlorophyll Water was selected by the Permanent Mission of ... Day 2019. , International Day of Yoga, unofficially referred to as Yoga Day, ... by the United Nations General Assembly. , Marking the International Yoga Day, the United ...
Breaking Medicine Technology:
Cached News: