HOME >> MEDICINE >> NEWS
UIC developing drug for SARS

A prototype drug created by researchers at the University of Illinois at Chicago shows promise in slowing replication of the virus responsible for severe acute respiratory syndrome, or SARS.

Currently, there are no effective antiviral agents or vaccines for SARS, which killed almost 800 people in an epidemic in 2002-2003.

On the basis of their success, the researchers have received an $8 million grant from the National Institute of Allergy and Infectious Diseases to develop protease inhibitors that would block key enzymes in the SARS virus and hamper its advance. Protease inhibitors, a class of drugs capable of disrupting enzymes that digest proteins, have been successfully used to thwart the human immunodeficiency virus, which causes AIDS.

"Data from SARS patients indicate that replication of the virus peaks 10 days after the onset of fever," said Michael Johnson, director of the Center for Pharmaceutical Biotechnology in the UIC College of Pharmacy and the study's principal investigator. "By administering protease inhibitors early, when feverish symptoms have started, the drugs could reduce the viral load and ameliorate the disease."

Like HIV, the SARS virus multiplies rapidly, hijacking the machinery of the cells it infects to clone itself over and over again.

One of the first steps in that process is the production of a long chain of proteins, all of which are needed for the virus to propagate. Two enzymes, or proteases, clip the chain to release the individual proteins, the parts needed to assemble a mature virus.

These two proteases -- called 3CLpro and PLpro -- are UIC's targets for drug therapy.

"If we can block 3CLpro and probably PLpro, then we can stop the SARS virus from replicating," Johnson said.

Under the grant, Andrew Mesecar, associate professor of pharmacy, will study details of the three-dimensional structure of the two enzymes using x-ray crystallography.

His technique invol
'"/>

Contact: Sharon Butler
sbutler@uic.edu
312-355-2522
University of Illinois at Chicago
8-Jun-2005


Page: 1 2 3

Related medicine news :

1. Program announced to improve care in developing areas for patients with blood disorders
2. Caring for the sick now a public health priority for developing countries
3. Over time, more women are developing MS than men
4. Addressing the neglect of childhood hearing impairment in developing countries
5. First step in developing heart hormone-based pill to control high blood pressure
6. USC-led study suggests exercise reduces risk of developing invasive breast cancer
7. Cells passed from mother to child may be first step in developing new treatments for type 1 diabetes
8. Tuberculosis risks for health workers in developing countries
9. Global strategies to improve health in developing countries need truly global discussions
10. Adolescent smokers have a greater risk of developing alcohol-use disorders than nonsmokers
11. Measuring brain activity for emotional markers that may indicate risk for developing alcoholism

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: UIC developing drug for SARS

(Date:3/3/2015)... NC (PRWEB) March 03, 2015 ... Dentist in Wilmington, NC has achieved Accredited ... Dentistry. , He achieved this accomplishment after ... oral examinations, as well as the submission of ... Edgerton of Wilmington, NC grew up in Connecticut, ...
(Date:3/3/2015)... Viejo, California (PRWEB) March 03, 2015 ... animated effect entitled inMotion3D Environment from Pixel Film Studios. ... a 2D HDRI image into 360° viewing area inside ... Studios. “inMotion3D Environment blurs the line between professional and ... Motion 5 users can turn their 2D HDRI images ...
(Date:3/3/2015)... March 03, 2015 Aureus Medical Group ... Physician jobs, has announced that it will participate as ... held Tuesday, March 17, 2015 in St. Louis, MO. ... to meet job-seeking residents and fellows in a comfortable, ... division will be available to speak with attendees ...
(Date:3/3/2015)... California (PRWEB) March 03, 2015 ... announced the release of a new plugin FCPX3D Confetti ... Confetti animates an exploding transition using confetti particles inside ... “When adding an FCPX3D Confetti transition, users will have ... Plugin.” , Transition from one clip to the next ...
(Date:3/2/2015)... Atlanta, GA (PRWEB) March 02, 2015 ... FTX digital billboard design. The FTX uses state-of-the-art ... image quality, performance reliability, and owner satisfaction. An ... industry, is the exclusive Formetco 10 year LED Brightness ... was designed to be a superior billboard among any ...
Breaking Medicine News(10 mins):Health News:Dr. Edgerton, a Dentist in Wilmington, NC, Achieves Accredited Status in AACD 2Health News:A New Plugin Entitled inMotion3D Environment Was Released Today from Pixel Film Studios Exclusively for Motion 5 2Health News:A new Confetti Generator entitled FCPX3D Confetti was released today from Pixel Film Studios for Final Cut Pro X 2Health News:Formetco Launches Innovative LED Billboard System 2
(Date:3/2/2015)... March 2, 2015 Cure SMA recently announced a ... Biomedical Research (CALIBR). This funding is an extension of a ... a $700,000 Cure SMA grant to Dr. Peter G. ... "Optimization of Small Molecules that Increase SMN2 Levels ... motor neuron (SMN) protein is critical to the function of ...
(Date:3/2/2015)... GLENWOOD, Ill. , March 2, 2015  Landauer, ... in personal and environmental radiation measurement and monitoring, outsourced ... today announced it will release financial results for the ... Monday, March 9, 2015. The Company ... Tuesday, March 10, 2015 at 9:00 a.m. Central Time ...
(Date:3/2/2015)... Amgen (NASDAQ: AMGN ) today ... evaluating Repatha TM (evolocumab), an investigational cholesterol-lowering medication, ... chronic heart failure, at the upcoming American College of ... held March 14-16 in San Diego ... antibody that inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9), ...
Breaking Medicine Technology:Cure SMA Announces $315,000 Grant to California Institute of Biomedical Research 2Cure SMA Announces $315,000 Grant to California Institute of Biomedical Research 3Landauer, Inc. Announces Date and Time for Announcement of Fiscal First Quarter 2015 Results and Conference Call 2Amgen Showcases Cardiovascular Pipeline At ACC.15 With New Cholesterol-Lowering And Chronic Heart Failure Data 2Amgen Showcases Cardiovascular Pipeline At ACC.15 With New Cholesterol-Lowering And Chronic Heart Failure Data 3Amgen Showcases Cardiovascular Pipeline At ACC.15 With New Cholesterol-Lowering And Chronic Heart Failure Data 4Amgen Showcases Cardiovascular Pipeline At ACC.15 With New Cholesterol-Lowering And Chronic Heart Failure Data 5Amgen Showcases Cardiovascular Pipeline At ACC.15 With New Cholesterol-Lowering And Chronic Heart Failure Data 6Amgen Showcases Cardiovascular Pipeline At ACC.15 With New Cholesterol-Lowering And Chronic Heart Failure Data 7Amgen Showcases Cardiovascular Pipeline At ACC.15 With New Cholesterol-Lowering And Chronic Heart Failure Data 8Amgen Showcases Cardiovascular Pipeline At ACC.15 With New Cholesterol-Lowering And Chronic Heart Failure Data 9Amgen Showcases Cardiovascular Pipeline At ACC.15 With New Cholesterol-Lowering And Chronic Heart Failure Data 10Amgen Showcases Cardiovascular Pipeline At ACC.15 With New Cholesterol-Lowering And Chronic Heart Failure Data 11
Cached News: