HOME >> MEDICINE >> NEWS
Unique results from Swedish study of HIV vaccine

A Swedish HIV vaccine study conducted by researchers at Karolinska Institutet (KI), Karolinska University Hospital and the Swedish Institute for Infectious Disease Control (SMI) has produced surprisingly good results. Over 90 per cent of the subjects in the phase 1 trials developed an immune response to HIV. "Never has such a good result been seen with a vaccine of this type," says Professor Eric Sandstrm, Chief Physician at Karolinska University Hospital.

A vaccine developed by SMI scientists has now undergone the first clinical study on healthy individuals in Sweden in order to examine its safety and different methods of administration. The vaccine is what is known as a genetic vaccine, which uses parts of the virus DNA to stimulate the rapid endogenous production of the proteins for which the injected DNA codes.

The trial subjects were vaccinated on three occasions with this vaccine using a needle-free method of injection. In order to enhance the effect, the researchers also gave the subjects a fourth dose of a vaccine in which parts of the HIV virus DNA had been integrated into another virus (vaccinia = the cowpox virus). This vaccine-based HIV vaccine is produced by the USA's National Institutes of Health and was donated for use in this Swedish study.

"Our vaccine is designed in such a way that it's able to protect against many of the circulating HIV types in Africa and the West," says Professor Britta Wahren at the SMI/KI.

Over 90 per cent of the trial subjects developed an immune response to HIV, and the vaccines have been tolerated well.

Data from the study will be presented at the four-day HIV vaccine conference in Amsterdam starting 29 August under the heading "Multigene, multiclade HIV-1 plasmid DNA prime and MVA boost is safe and highly immunogenic in healthy human volunteers".

Scientists now hope to follow up the Swedish study with a larger phase 1 phase 2 study in Tanzania, planned to com
'"/>

Contact: Katarina Sternudd
katarina.sternudd@ki.se
46-852-483-895
Karolinska Institutet
30-Aug-2006


Page: 1 2

Related medicine news :

1. Unique laboratory could make pavements more user-friendly
2. No butts about it: Unique UH database shows Texas is crushing out smoking
3. Unique vascular dysfunction in womens heart disease described in major journal supplement
4. Stem cell transplantation procedure results in long-term survival for amyloidosis patients
5. GSKs Pazopanib shows positive results in patients with advanced renal cell carcinoma
6. GSKs Pazopanib shows positive results in patients with advanced RCC and ovarian cancer
7. Targeted, oral agent Enzastaurin shows favorable results
8. Childhood obesity intervention shows promising results
9. Alpharma presents positive pharmacokinetic study results
10. UCSF brain tumor vaccine trial shows promising results
11. The eyes have it -- Autism research yields surprising results

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/27/2017)... ... ... The Los Angeles leg of the US movie premier of the Man in the Camo ... the Clive Davis Theater inside the Grammy Museum Located in downtown Los Angeles in the ... Welsh rock musician, Mike Peters (of The Alarm), his rise to fame, battle with cancer ...
(Date:7/27/2017)... ... July 27, 2017 , ... Team Novo Nordisk, the ... to the men’s pro squad as a stagiaire for the remainder of the 2017 ... debut on July 31st at the Tour of Utah. , “Every season we are ...
(Date:7/26/2017)... Miami, FL (PRWEB) , ... July 26, 2017 , ... ... caps that treat hereditary hair loss. The new Flexible Fitting Design offers a more ... of Capillus, LLC is delighted with the improvements to the home-use laser therapy caps ...
(Date:7/26/2017)... ... July 26, 2017 , ... A major challenge many labs face is a ... and a lengthy freeze dry cycle are a few common challenges that can overcome ... well as new accessories and advancements in laboratory freeze dryers that will improve quality ...
(Date:7/26/2017)... ... July 27, 2017 , ... It's time to sign up for the new One-A-Month ... says Kathy Heshelow, founder of Sublime Naturals and author of numerous books on essential oils. ... month, mailed by the 5th. , Two items are included in the ...
Breaking Medicine News(10 mins):
(Date:7/14/2017)... , July 13, 2017 It should come as ... is in the midst of a crippling opioid ... since 1999, the number of overdose deaths from opiate-based medications ... over half a million dead from 2001 to 2015". During ... and hydrocodone has similarly quadrupled, drawing a compelling link between ...
(Date:7/12/2017)... , July 12, 2017 CarpalAID is a revolutionary new ... or surgery. Carpal tunnel syndrome affects more than 8 ... twice the rate of men. The common methods of treating CTS ... with uncomfortable hand braces or gloves. ... CarpalAID is a clear patch worn ...
(Date:7/11/2017)... 2017  The global market for liquid biopsy diagnostic ... million in 2016.  Although in early stages, the global ... particular as a result of the gradual shift towards ... introduction of a significant number of new liquid biopsy ... tumor biomarkers to guide treatment decisions. ...
Breaking Medicine Technology:
Cached News: