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Unique vascular dysfunction in women's heart disease described in major journal supplement

ported activities of daily living. These are translated into METs (metabolic equivalents), which are used to approximate physical work capacity. Two-thirds of the cardiac events in the WISE women occurred in those with an estimated capacity of less than 4.7 DASI METs. Women with evidence of lower scores were also significantly more likely to have risk factors and obstructive coronary artery disease.

  • Overweight women are more likely than normal weight women to have coronary artery disease risk factors. But the WISE researchers found that the issue is not obesity alone. Instead, it appears that the metabolic alterations associated with obesity are key factors in placing a woman at risk for CAD and cardiac events. Women with the "metabolic syndrome" are at much higher risk of cardiac events than those with a normal metabolic status. The metabolic syndrome includes insulin resistance, unhealthy cholesterol and/or triglyceride levels, hypertension, and abdominal obesity.
  • The recognition of different, unique risk factors for IHD in women such as inflammatory processes in the arteries, anemia and microvascular dysfunction leads to the possibility that different diagnostic and prognostic tools may be employed. Among options currently being evaluated are high-sensitivity C-reactive protein (a laboratory test that can detect inflammatory processes), hemoglobin monitoring, and retinal artery narrowing examinations and coronary calcification tests (for detection of atherosclerosis).

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    Contact: Sandy Van
    sandy@prpacific.com
    800-880-2397
    Cedars-Sinai Medical Center
    3-Feb-2006


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