Untreated low-grade ductal carcinoma in situ poses long-term risk

Ductal carcinoma in situ (DCIS) of the breast develops into invasive breast cancer (IBC) in approximately 50 percent of women if left untreated, with the risk extending over more than forty years, according to a new study appearing in the June 15, 2005 issue of CANCER (http://www.interscience.wiley.com/cancer-newsroom), a peer-reviewed journal of the American Cancer Society. The study, a four-decade long follow-up of women with low-grade DCIS treated by biopsy alone from 1950-1968, reveals the natural history of this poorly understood breast cancer and supports curative treatment by surgical excision.

In the decades prior to mammographic screening, DCIS--presented as breast lump--was recognized microscopically by its high-grade features similar to invasive cancer, and represented only a small subset of all breast cancers. Small low-grade DCIS lesions simply were not recognized and were thus diagnosed as benign. Over the next 20-30 years, as criteria for diagnosis of DCIS were redefined, DCIS has gradually been recognized as spectrum of disease varying considerably in grade and extent. However, important differences in the clinical course of low- and high-grade disease have not always been appreciated. In addition, the distinction between low-grade and DCIS and the histologically similar but lesser lesions of atypical ductal hyperplasia (ADH) is critical as ADH lesions pose only small malignancy risk and predict risk to both breasts rather than regional risk. With the advent of mammography, DCIS is now identified earlier and is the largest growing subset of breast cancers. Understanding the natural history of low-grade DCIS can provide insight into current and future treatment strategies.

Led by Melinda E. Sanders, M.D. and David L. Page, M.D. of the Vanderbilt University Medical Center in Nashville, researchers followed the course of 28 women treated by biopsy only in the 1950s and 1960

Contact: David Greenberg
John Wiley & Sons, Inc.

Page: 1 2

Related medicine news :

1. Long-term outcomes promising for patients with localized, low-grade prostate cancer
2. Correlation between bile duct obstruction and ductal cancer found
3. Lobular breast cancer can be managed as ductal cancer
4. GSKs Pazopanib shows positive results in patients with advanced renal cell carcinoma
5. Doctors conclude temsirolimus is effective new treatment for advanced renal cell carcinoma
6. Aspirin might prevent development of oesophageal adenocarcinoma
7. Mayor of New York proposes preventing 100 million deaths from tobacco
8. HIVMA opposes The Gambias unproven AIDS remedy
9. Swishing once a day with mouthrinse poses no harm to dental work
10. Elders death at airstrip: Research exposes deeper issues
11. Stalking poses serious public health problem

Post Your Comments:

(Date:7/17/2019)... , ... July 17, 2019 , ... ... and client engagement options for human services providers worldwide, has been awarded a ... CMAS program streamlines the procurement process for state and local government agencies in ...
(Date:7/17/2019)... ... July 17, 2019 , ... The Coalition of Medication-Assisted Treatment ... seven of its member Opioid Treatment Programs (OTPs) at 12 locations are participating ... virus (HCV) with the goal of achieving better outcomes through telemedicine. The study, ...
(Date:7/13/2019)... ... , ... Dr. Rupa Jolly, dentist and wife of Dr. Tarun Jolly of ... Influential New Orleanians in 2019. She joins more than 20 other locals on the ... impact on the New Orleans community. , Combining their backgrounds in science and medicine, ...
(Date:7/13/2019)... ... 12, 2019 , ... cbdMD, Inc., a nationally recognized consumer ... by Brightfield Group, a leading cannabis research firm. In their recent mid-year 2019 ... companies in two categories, Topicals and Skincare/Beauty. , "There is a massive shakeup ...
(Date:7/12/2019)... ... July 12, 2019 , ... Rebecca Baxt, M.D., F.A.A.D. and Saida ... Docs for 2019. Located in Paramus, BAXT CosMedical is a renowned facility that believes ... dermatological care for the past 45 years. , NJ Top Docs, Dr. Rebecca Baxt ...
Breaking Medicine News(10 mins):
(Date:7/17/2019)... ... 2019 , ... Gwinnett Family Dental Care , located at 3455 Lawrenceville ... care, including general and preventative care as well as restorative and cosmetic dentistry ... trained dentists, Dr. Kell Gallaher, Dr. Jon Klevansky, Dr. Jason Klevansky, Dr. Joseph Baughman, ...
(Date:7/17/2019)... SAN DIEGO (PRWEB) , ... July 17, 2019 ... ... today announced that DFree ®, the first wearable for urinary incontinence, will ... Stanford University in Stanford, CA, on July 26, 2019. The Innovation Showcase recognizes ...
(Date:7/17/2019)... ... July 17, 2019 , ... Cognition Corporation , a ... a new e-book on developing user needs for life science products. , ... small part of the compliance process and the guiding force for product design. ...
Breaking Medicine Technology:
Cached News: