Use of chemotherapy after surgery for colon cancer has risen, with increase in survival rate

More patients with stage III colon cancer are receiving chemotherapy after surgery, with an associated significant increase in 5-year survival, according to a study in the December 7 issue of JAMA. The study also found that women, blacks and the elderly were less likely to receive this treatment.

According to background information in the article, based on the results of two trials, the National Institutes of Health Consensus Conference recommended in 1990 that adjuvant chemotherapy (chemotherapy after the primary tumor has been removed by some other method, as in surgery or radiation therapy) be given to all patients with stage III colon cancer who were not enrolled in a clinical trial. However, as with most recommendations, it is not clear to what extent they are followed or contribute to outcome in the general population.

J. Milburn Jessup, M.D., of the National Cancer Institute, Rockville, Md., and colleagues assessed to what extent the 1990 Consensus Conference recommendation has been followed in the community and whether adjuvant chemotherapy has improved the 5-year survival of patients with stage III colon cancer. The study included data from 85,934 patients with stage III colon cancer from 560 hospital cancer registries who were entered into the National Cancer Data Base (NCDB) between 1990 and 2002. The data included standard clinical, pathological, and first course of treatment variables.

The researchers found an increase in the use of adjuvant chemotherapy for all patients with stage III colon cancers from 39 percent of patients in 1990 to 64 percent in 2002, but use was lower in black, female, and elderly patients. The difference in 5 year survival increased from an 8 percent improvement in the 1991 subgroup to 16 percent in the 1997 subgroup that received adjuvant chemotherapy compared with surgery alone. The researchers also found that adjuvant chemotherapy increases survival in elderly patients as much as it does in younger p

Contact: Liz McDonald
JAMA and Archives Journals

Page: 1 2

Related medicine news :

1. Nonsmall cell lung cancer -- chemotherapy before surgery appears better than surgery alone
2. Trial shows circulating tumor cells predict how prostate cancer patients do with chemotherapy
3. Brain-boosting pill alleviates post-chemotherapy fogginess
4. Pre-operative chemotherapy does not increase survival rates for nonsmall cell lung cancer
5. Most pediatric chemotherapy mistakes reach patients
6. Growth factors given with chemotherapy associated with increased risk of blood diseases
7. Clear guidelines on oral chemotherapy needed
8. Survey reveals need for standardized oral chemotherapy prescribing practices, safeguards
9. Genomic tests improve prediction of breast cancer response to chemotherapy, hormonal therapy
10. Report calls for using heated chemotherapy after colon cancer surgery to optimize patient survival
11. Order of chemotherapy, radiation has no effect on breast cancer survival

Post Your Comments:

(Date:9/1/2020)... , ... September 01, 2020 , ... ... has completed $3 million convertible note financing, which will be used to accelerate ... the funds from this financing, the company will continue to expand its customer ...
(Date:9/1/2020)... ... 01, 2020 , ... As fall and winter swiftly approach and many businesses ... has taken this time to expand and grow into a full-fledged natural health clinic ... Institute will be relaunching its brand new website, expanding its services menu and has ...
(Date:8/31/2020)... ... August 31, 2020 , ... Cardiothoracic ... joining biomedical engineers from Carnegie Mellon University (CMU) to develop a new heart ... have undergone open heart surgery. , The AGH/CMU team was recently awarded a ...
(Date:8/31/2020)... ... August 31, 2020 , ... Just found out your dear friend has cancer? , It’s ... friend or family member shares their diagnosis. Once the shock wears off, the questions and ... thing? What are the best ways to help? Words are failing me. I’m scared. I ...
(Date:8/31/2020)... (PRWEB) , ... August 31, 2020 , ... Want to ... 1, Cerebral Palsy Alliance Research Foundation (CPARF) is thrilled to launch its fourth annual ... research. A fully virtual challenge, STEPtember meets everyone wherever they are at this moment ...
Breaking Medicine News(10 mins):
(Date:8/31/2020)... ... , ... If you live in New York City you will always pay more for these ... law of supply and demand, but are plastic surgeons in New York worth the premium ... patients that make the four-hour trip to have expert aesthetic treatments by some of the ...
(Date:8/28/2020)... (PRWEB) , ... August 28, 2020 , ... Dr. ... reproductive and endoscopic surgeon and serves as a clinical professor in the Department of ... of the American Laparoscopy Society & Pacific Coast Reproductive Society and is a Clinical ...
(Date:8/27/2020)... ... ... season is right round the corner and the risk of getting caught by influenza is ... begins to harbor its effects on us. Already with the sudden outbreak of COVID 19, ... lives. Hence it has become even more relevant to keep oneself immune from any of ...
Breaking Medicine Technology:
Cached News: