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Use of high hydrostatic pressure to inactivate Hepatitis A virus in oysters studied

Blacksburg, Va. NOAA/Virginia Sea Grant has awarded Virginia Tech $119,000 to study whether high hydrostatic pressure will inactivate Hepatitis A virus in both shucked and unshucked oysters.

The project, led by Daniel Holliman, an M.D. with the High Pressure Processing Laboratory, and Laura Douglas, lab manager, will identify one or more effective high pressure processing schedules. The laboratory is a facility of the Department of Food Science and Technology at Virginia Tech, devoted to improving food safety and food processing.

Hepatitis A virus (HAV) is one of the more serious illnesses transmissible by shellfish. Worldwide, HAV is responsible for more than 1.5 million cases of the disease each year, with 260,000 cases and more than 100 deaths in the United States. Hepatitis A infection is characterized by fatigue, malaise, fever, loss of appetite, nausea, vomiting, joint and muscle aches, and abdominal pain, coupled with the onset of jaundice, a yellowing of the whites of the eyes, and dark urine. The disease generally runs its course in two months, but can linger as long as six. While survival rates for Hepatitis A are above 99 percent, the disease can be very dangerous for infants, the elderly, immunosuppressed people, and those with existing liver disease.

Bivalve shellfish, such as oysters, have been demonstrated to concentrate pathogenic organisms from their environment. In some cases, sewage contamination of harvesting areas, either from coastal runoff or ship discharges, has been shown to result in HAV contamination of oysters. Several studies have demonstrated remarkable concentration and persistence of HAV in shellfish exposed to the virus through their surrounding seawater. Even with depuration, HAV may persist in oysters for several weeks after exposure. The virus also is fairly resistant to heating and may remain viable in shellfish after up to five minutes of steaming.

For these reasons, high hydrostatic pressure tr
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Contact: Angela Correa
acorrea@vt.edu
540-231-2075
Virginia Tech
7-Jun-2005


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