The findings could have further significance for those women taking low-dose oral contraceptives who already are at increased risk for such events because of polycystic ovary syndrome, or metabolic disorder, according to John Nestler, M.D., professor and chair of the Division of Endocrinology and Metabolism in the VCU School of Medicine.
In the study, researchers reported that the overall estimated risk of cardiovascular events both heart attack and stroke -- among current low-dose oral contraceptive users was doubled compared to non-users.
The findings are based on a meta-analysis of peer-reviewed literature. The researchers examined several separate-but-similar experiments that were designed to assess the risk of cardiovascular disease associated with the current use of low-dose oral contraceptives in the population-at-large. The analysis included studies published between January 1980 and October 2002.
"The study suggests that women in general are at an increased risk of having a cardiovascular event while taking even these third-generation, low-dose, birth control pills," said Nestler.
"Prolonged exposure to low-dose oral contraceptives in a population at higher risk may significantly increase the incidence of cardiovascular outcomes and prompt consideration of alternative therapeutic or contraceptive interventions," he wrote.
"A number of women with metabolic syndrome or polycystic ovary syndrome already are at increased risk for heart attack, and a majority of women with PCOS are treated with low-dose oral contraceptives for a prolonged period of time," he said. "An insulin-sensi
Contact: Malorie Janis
Virginia Commonwealth University