HOME >> MEDICINE >> NEWS
Variations in four inflammatory genes may predispose Mexican Americans to insulin resistance

t use insulin properly. As a result, the pancreas tries to keep up with the demand for insulin by producing more, causing excess sugar to build up in the blood. Over time, insulin resistance leads to heart disease, diabetes, high blood pressure, obesity and polycystic ovarian syndrome. In fact, about 25 percent 68 million adult Americans have insulin resistance, with Mexican Americans having the highest prevalence.

"Because insulin resistance and heart disease are so common in the Mexican American population and we know that chronic low-grade inflammation is associated with these diseases, our group wanted to investigate whether specific inflammatory genes might be involved," Rotter said.

To determine whether specific variations in the genes that control inflammatory responses were directly linked to insulin resistance, researchers at Cedars-Sinai and the University of California, Los Angeles, studied a large, high-risk population of Mexican Americans. Using the most precise diagnostic and genetic tests, the investigators examined the link between variations in 31 of the most common inflammatory genes and insulin resistance.

The researchers examined the DNA of 656 Mexican American family members participating in the study and identified 41 variations in the 31 inflammatory genes. Among these family members, 394 adult offspring and their spouses were then tested for insulin sensitivity with the glucose clamp, the most precise diagnostic test for insulin resistance, by receiving an infusion of insulin in one arm over a two-hour period. At the same time, blood samples were drawn from the other arm to measure how much glucose was present in the blood. Depending on blood glucose levels, sugar was added to see how well the cells used it. Patients were found to be less insulin resistant when the samples showed low blood sugar levels even when glucose was added, indicating that the cells were taking up glucose. However, when little or
'"/>

Contact: Kelli Hanley
kelli.hanley@cshs.org
310-423-3674
Cedars-Sinai Medical Center
11-Jun-2005


Page: 1 2 3 4

Related medicine news :

1. Variations in detoxifying genes linked to Lou Gehrigs disease
2. Green tea holds promise as new treatment for inflammatory skin diseases
3. Novel anti-oxidant and anti-inflammatory agent shows effectiveness on key endpoints in trial
4. Psychosocial factors associated with higher levels of inflammatory markers
5. Study finds lapatinib shows promise as therapy for inflammatory breast cancer
6. Blood cells linked to heart attacks, other inflammatory diseases
7. Nonsteroidal anti-inflammatory drugs use associated with higher gastrointestinal complications
8. Anti-inflammatory drug prevents liver cancer in at-risk liver patients
9. Anti-inflammatory drugs following hip replacement surgery could harm rather than help
10. New cell-based targets for treating autoimmune inflammatory diseases
11. Non-steroidal anti-inflammatory drugs (NSAIDs) and congenital anomalies

Post Your Comments:
(Date:12/15/2014)... SIMpalm, a leading mobile app development company , ... client, which allows users to keep track of wines ... the right wine. At the center of WineMatch ... and wine information. All this information is assembled to ... that are close counterparts to one another are called ...
(Date:12/15/2014)... Reinberg HealthDay Reporter FRIDAY, ... should reassure the millions of American women who have migraine: ... "There is no association between migraine and breast cancer ... medicine at Harvard Medical School. "There is no positive association, ... no protective effect either." About 18 percent of American ...
(Date:12/15/2014)... December 15, 2014 Kathy McAfee, America's ... Women World Awards in the category of Best Blog ... award for her weekly career blog Networking Ahead ... to help professionals elevate their talent and influence through ... named after her book Networking Ahead for Business, has ...
(Date:12/15/2014)... December 15, 2014 At the leading, ... AutismOne and Focus Autism will ... with research on the effects of toxins to children’s ... intervention information. , Luminaries such as Dr. Lucija ... abroad with esteemed, credentialed colleagues of the United States ...
(Date:12/15/2014)... 2014 For the second year in a ... 30 Coffees of 2014.” Bird Rock Coffee Roasters’ Sumatra Ulos ... Ethiopia at number 10. This is the first year that ... selection is ranked on quality, value, and other aspects, including ... out of 100, and at $17.99 for 12-ounces, was also ...
Breaking Medicine News(10 mins):Health News:Use WinMatch Connect App to Keep Track of Wines You Like 2Health News: No Link Between Migraine, Breast Cancer Risk, Study Says 2Health News:Kathy McAfee, America’s Marketing Motivator, Wins Best Blog from Women World Awards 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 3Health News:Bird Rock Coffee Roasters Ranks Second and Tenth in Coffee Review’s ‘Top 30 Coffees of 2014’ 2
(Date:12/15/2014)... 2014  Colorado and Washington State ... of cannabis. Oregon , Alaska ... prohibition during the November 2014 elections. Photo ... The benefits of legalizing cannabis are ... like the increased tax revenue for state and local governments, ...
(Date:12/15/2014)... 2014  Stephen Squires, CEO and founder of leading ... (OTCQB:QTMM), will be speaking at the launch event ... December 16th, 2014. The RCQM launch continues Rice University,s ... top faculty and students and by inviting the world,s ... "We have a long association with Rice ...
(Date:12/15/2014)... and BOSTON , December ... leading GPCR structure-guided drug discovery and development company, is ... in the United States relating ... these patents in the US significantly strengthens the global ... major pharmaceutical markets. The suite of patents ...
Breaking Medicine Technology:CannaInsider.com Estimates 200,000 New Jobs in the Cannabis Industry by 2015 2Quantum Materials CEO Stephen Squires to Speak at Rice Center for Quantum Materials Launch 2Quantum Materials CEO Stephen Squires to Speak at Rice Center for Quantum Materials Launch 3Heptares Extends Global Patent Protection for GPCR-Focused Drug Discovery Platform With Grant of Core Patents in the United States 2
Cached News: