HOME >> MEDICINE >> NEWS
Variations in four inflammatory genes may predispose Mexican Americans to insulin resistance

t use insulin properly. As a result, the pancreas tries to keep up with the demand for insulin by producing more, causing excess sugar to build up in the blood. Over time, insulin resistance leads to heart disease, diabetes, high blood pressure, obesity and polycystic ovarian syndrome. In fact, about 25 percent 68 million adult Americans have insulin resistance, with Mexican Americans having the highest prevalence.

"Because insulin resistance and heart disease are so common in the Mexican American population and we know that chronic low-grade inflammation is associated with these diseases, our group wanted to investigate whether specific inflammatory genes might be involved," Rotter said.

To determine whether specific variations in the genes that control inflammatory responses were directly linked to insulin resistance, researchers at Cedars-Sinai and the University of California, Los Angeles, studied a large, high-risk population of Mexican Americans. Using the most precise diagnostic and genetic tests, the investigators examined the link between variations in 31 of the most common inflammatory genes and insulin resistance.

The researchers examined the DNA of 656 Mexican American family members participating in the study and identified 41 variations in the 31 inflammatory genes. Among these family members, 394 adult offspring and their spouses were then tested for insulin sensitivity with the glucose clamp, the most precise diagnostic test for insulin resistance, by receiving an infusion of insulin in one arm over a two-hour period. At the same time, blood samples were drawn from the other arm to measure how much glucose was present in the blood. Depending on blood glucose levels, sugar was added to see how well the cells used it. Patients were found to be less insulin resistant when the samples showed low blood sugar levels even when glucose was added, indicating that the cells were taking up glucose. However, when little or
'"/>

Contact: Kelli Hanley
kelli.hanley@cshs.org
310-423-3674
Cedars-Sinai Medical Center
11-Jun-2005


Page: 1 2 3 4

Related medicine news :

1. Variations in detoxifying genes linked to Lou Gehrigs disease
2. Green tea holds promise as new treatment for inflammatory skin diseases
3. Novel anti-oxidant and anti-inflammatory agent shows effectiveness on key endpoints in trial
4. Psychosocial factors associated with higher levels of inflammatory markers
5. Study finds lapatinib shows promise as therapy for inflammatory breast cancer
6. Blood cells linked to heart attacks, other inflammatory diseases
7. Nonsteroidal anti-inflammatory drugs use associated with higher gastrointestinal complications
8. Anti-inflammatory drug prevents liver cancer in at-risk liver patients
9. Anti-inflammatory drugs following hip replacement surgery could harm rather than help
10. New cell-based targets for treating autoimmune inflammatory diseases
11. Non-steroidal anti-inflammatory drugs (NSAIDs) and congenital anomalies

Post Your Comments:
(Date:4/23/2014)... "simple and accessible detection methods that can rapidly ... of a single cell inside that population has ... Chang Lu. , In the Royal Society of ... announced that he and his coworkers have developed ... of a protein ( Chem. Sci. , 2014, ...
(Date:4/23/2014)... are often displayed in the popular Swedish children,s ... of high-sugar foods. A new study from the ... in children,s TV programmes as well as the ... and weight status. , Steingerdur Olafsdottir,s doctoral thesis ... popular Swedish children,s TV show Bolibompa. Healthy foods ...
(Date:4/23/2014)... led by a researcher from the Cancer Science Institute ... Singapore has identified the cancer specific stem cell which ... of developing new drugs for the treatment of this ... group, led by Dr Chan Shing Leng, Research Assistant ... that a cancer-specific variant of a cell surface protein, ...
(Date:4/23/2014)... in the journal Oncotarget , explored tumour ... or their own DNA signatures within the same ... design effective, targeted treatment strategies. , Firstly they ... and either the KRAS or BRAF mutation. Secondly, ... EGFR gene mutation have that specific mutation present ...
(Date:4/23/2014)... Alzheimer,s disease has been a rapidly evolving pursuit ... latest crook in the research road, scientists have ... proteins associated with the disease. The report, which ... , could have important implications for developing novel ... colleagues explain that for years, research has suggested ...
Breaking Medicine News(10 mins):Health News:Following a protein's travel inside cells is key to improving patient monitoring, drug development 2Health News:High-calorie and low-nutrient foods in kids' TV 2Health News:Scientists identify cancer specific cell for potential treatment of gastric cancer 2Health News:Scientists identify cancer specific cell for potential treatment of gastric cancer 3Health News:Non-uniform genetic mutations identified in lung cancers could lead to targeted treatment 2
(Date:1/15/2014)... , Jan. 15, 2014 Reportlinker.com announces ... available in its catalogue: ... Forecast and Market Analysis to 2022 ... Atopic Dermatitis - India Drug Forecast and ...
(Date:1/15/2014)... , Jan. 15, 2014  Zafgen, Inc., a ... needs of severely obese patients, today announced initial ... a selective inhibitor of methionine aminopeptidase 2 (MetAP2), ... form of genetic obesity.  These results showed improvements ...
(Date:1/14/2014)... InformEx, North America,s leading business partnering ... the 30 th edition of its annual conference at ... January 21-24. (Logo: http://photos.prnewswire.com/prnh/20131028/NY05330LOGO-a ) ... and specialty chemical companies will take part in the conference, ...
Breaking Medicine Technology:PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 2PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 3PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 4PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 5Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 2Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 3Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 4Media Advisory: InformEx 2014 Events & Speaker Lineup for 30th Edition Conference in Miami Beach 2
Cached News: