HOME >> MEDICINE >> NEWS
Viagra blunts effects of stress on the human heart

Sildenafil citrate (Viagra), a drug used to treat erectile dysfunction (ED) in millions of men, reduces the stimulatory effects of hormonal stress on the heart by half, according to results of a new study by researchers at Johns Hopkins.

While sildenafil is more widely known for helping genital blood vessels expand to maintain an erection and, more recently, as a treatment for pulmonary hypertension, it has been thought to have little direct effect on the human heart.

In the heart, sildenafil blunts the strengthened heart beat caused by chemically induced stress, thereby lessening the excess amount of blood and force used to pump it to the body, according to study senior author and cardiologist David Kass, M.D., a professor at The Johns Hopkins University School of Medicine and its Heart Institute.

"Sildenafil effectively puts a 'brake' on chemical stimulation of the heart," says Kass.

The researchers' findings, which appear in the journal Circulation online Oct. 24, are believed to be the first confirmation in humans that sildenafil has a direct effect on the heart. Previous research by Kass and his team showed that sildenafil had such effects in mice, blocking the short-term effects of hormonal stress in the heart. Related studies by the group also showed that sildenafil prevents and reverses the long-term effects in the heart from chronic high blood pressure.

Moreover, Kass adds, the latest Hopkins results confirm that sildenafil helps control heart function only when the heart is under duress, but has little impact under normal conditions.

Separate research from Kass and his team published earlier this year in the journal Nature Medicine showed that, in mice, sildenafil could reverse the negative effects on heart muscle weakened by heart failure and enlargement, a condition called hypertrophy. "But we had no firm evidence as to whether or how this therapy might work in the human heart. Our latest resear
'"/>

Contact: David March
dmarch1@jhmi.edu
410-955-1534
Johns Hopkins Medical Institutions
24-Oct-2005


Page: 1 2 3

Related medicine news :

1. Viagra, unlikely tool for vision research, slows the visual response to flickering light
2. Viagra improves urinary tract symptoms in men with erectile dysfunction
3. Sildenafil (Viagra) approved for treatment of pulmonary arterial hypertension (PAH) as Revatio
4. Low-carb diets effects linked to rise in newly identified starvation hormone
5. Researchers find deadly prescription drug effects 6 years before FDA
6. New long-term data analyses for Bifeprunox show favorable effects vs. placebo
7. Chemical maps hint at drugs effects on schizophrenia
8. Agent protects cells from lethal effects of radiation even if given after exposure
9. OCT1 required for therapeutic effects of diabetes drug Metformin
10. Online book helps children understand the effects of stroke
11. Mechanism of hallucinogens effects discovered

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/26/2020)... WASHINGTON (PRWEB) , ... May ... ... discovered a previously unknown mechanism through which certain infections can impact the ... PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections) and PANS (Pediatric ...
(Date:5/25/2020)... NAPA, Calif (PRWEB) , ... May 23, 2020 , ... ... of the moment. We wanted to present something whimsical and delicious in these complicated ... 2018 Red Wine Blend ($34.99) and 2018 Grenache ($24.99). The Chardonnay and Red Wine ...
(Date:5/21/2020)... ... May 21, 2020 , ... Having ... of GSCG, VITA NOVAS has already gained ground with the inherited reputation of ... stimulating biological products intravenously, guaranteeing an effective way for the ingredients to become ...
(Date:5/21/2020)... ... May 21, 2020 , ... The Rise of Mental ... been a lot of complications and adjustments, needless to say, more complications. With rising ... since the great depression it can be hard to escape and find peace. Adding ...
(Date:5/16/2020)... ... , ... For patients who have gone to see Andy Gaertner, D.M.D , in the ... in place. After being allowed to re-open during the current pandemic, they have put some ... safe and comfortable as possible while going through their dental exams and treatments. , The ...
Breaking Medicine News(10 mins):
(Date:5/30/2020)... (PRWEB) , ... May 29, 2020 , ... ... following statement in response to the U.S. announcement that it will terminate its ... the Administration’s announcement that it plans to terminate its relationship with the World ...
(Date:5/28/2020)... N.J. (PRWEB) , ... May 28, 2020 , ... ... heart, lung, and vascular hospital, and an Alliance member of the Cleveland Clinic ... for patients diagnosed with chronic obstructive pulmonary disease (COPD). , COPD is a ...
(Date:5/27/2020)... ... ... Dr. Anuj Shah , CHIROPRACTIC CARE, Bergen County, ... , Morris County, Dr. Derek Ferguson , ... County, Dr. Krista King , Union County, ...
Breaking Medicine Technology:
Cached News: