Vitamin D and calcium supplements have varied effects on breast cancer risk

A large multicenter randomized clinical trial reported that supplementation with calcium and vitamin D did not reduce breast cancer risk in the overall population. However, exploratory analyses suggest the effect of vitamin D and calcium supplements on breast cancer risk may vary according to a woman's initial supplement use.

"Our findings suggest that calcium and vitamin D supplementation may reduce breast cancer risk in some women, but more research is needed to clarify these results," said Rowan T. Chlebowski, MD, PhD, Medical Oncologist at the Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed) and the study's lead author. "We can't yet make a general recommendation about how much calcium and vitamin D individuals should take each day as supplements."

This study, part of the Women's Health Initiative, included 36,282 postmenopausal women without prior breast cancer at 40 centers in the United States. Breast cancer incidence was compared between 18,176 women randomly assigned to receive 1000 mg of elemental calcium carbonate and 400 IU of vitamin D3 daily, and 18,106 who received a placebo.

After a median follow-up time of seven years, breast cancer incidence did not differ significantly between the two groups overall (2.9% with breast cancer in the calcium/vitamin D group versus 3.0% in the placebo group). Among the women who did develop breast cancer, mean breast tumor size was smaller in the calcium/vitamin D group (1.54 cm versus 1.71 cm, p=0.05).

Women were allowed to continue personal use of calcium and vitamin D supplements as well as those provided in the randomized trial. Among the 19,115 women not reporting any supplement use at entry, the risk of developing breast cancer was reduced by 18% in the calcium / vitamin D group compared with women who received a placebo (Hazard Ratio (HR) 0.82, 95% Confidence Interval (CI) 0.70-0.97). In contrast, no reduction was seen in women already using

Contact: Rowan Chlebowski, MD, PhD
Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed)

Page: 1 2

Related medicine news :

1. Vitamin D supplements may offer cheap and effective immune system boost against TB
2. Vitamin D supplements should be given to Asian children for two years from birth
3. Vitamin A deficiency linked to major intestinal surgery
4. Vitamin D targets thrombosis in cancer patients
5. Vitamin C depletion correlates with lower body fat, not weight loss during short-term diet
6. Vitamin C and E supplements do not prevent pre-eclampsia in pregnant women at risk
7. Vitamin D inhibits progression of some prostate cancers
8. Vitamin D signals to prevent bone loss during osteoporosis
9. Vitamin D supplementation during pregnancy could reduce osteoporosis in children
10. Vitamin D can play role in lung health
11. Vitamin D status appears more important than high calcium intake for maintaining calcium metabolism

Post Your Comments:

(Date:10/8/2019)... Texas (PRWEB) , ... October 08, 2019 , ... ... intelligence company, appointed distinguished innovator, Dr. Jerry Henderson as Chief Medical Officer. Dr. ... data registries analytics platforms. , Dr. Henderson previously served as Chair of ...
(Date:10/8/2019)... (PRWEB) , ... October 08, 2019 , ... ... selected CardioWise, Inc. a Digital Health Awards 1st Round (Top Ten) ... Digital Health Awards was to select companies that promote faster, better, more cost-effective ...
(Date:10/8/2019)... ... October 08, 2019 , ... Join Director of ... and Infectious Disease Physician at Loyola University Medical Center, Fritzie Albarillo, MD, in ... The speakers will discuss the benefits and challenges with implementing a syndromic multiplex ...
(Date:10/8/2019)... (PRWEB) , ... October 08, 2019 , ... ... released the findings of a new study showing that Care4U™ 2’-FL, a DuPont ... to galacto-oligosaccharides (GOS) and lactose. The effects elicited to microbiota and metabolite composition ...
(Date:10/8/2019)... ... October 08, 2019 , ... Smile Haus in West Hills, California is excited ... Dr. Mustapha Hotait founded Smile Haus, one of his first priorities was to launch ... appointments, learn about the practice, and complete new patient forms online. , According to ...
Breaking Medicine News(10 mins):
(Date:10/8/2019)... ... 2019 , ... “When Seconds Count: Reports From an Emergency Medical Helicopter Pilot”: ... world through telling the real stories of the EMS flight crew. “When Seconds Count: ... A. Humphrey, an EMS helicopter pilot. He has been a pilot in the HEMS ...
(Date:10/8/2019)... ... , ... Dr. Ryan McNally, ND, MS, PA and Dr. Shashita Inamdar, MD, ... conference. Their presentation titled Advances in Integrative Neuropsychiatry and Functional Mental Health, will evaluate ... promote brain health, and reduce the debilitating symptoms of a range of neuropsychiatric disorders. ...
(Date:10/8/2019)... ... October 08, 2019 , ... Dr. ... raise awareness of their advanced dental and medical training to offer medically ... welcome patients with heart conditions, diabetes, and other systemic concerns for dental implants ...
Breaking Medicine Technology:
Cached News: