HOME >> MEDICINE >> NEWS
Vitamin D signals to prevent bone loss during osteoporosis

The risk of bone fracture resulting from falls increases as we age due to bone loss and osteoporosis. Physicians have routinely prescribed vitamin D and vitamin Drelated drugs to retard bone loss, but until now, little was known about the specific targets of vitamin D in bone. In a study appearing online on January 19 in advance of print publication in the February 2006 issue of the Journal of Clinical Investigation, Kyoji Ikeda and colleagues from the National Center for Geriatrics and Gerontology in Japan examine mice with severe osteoporosis and show that oral vitamin D treatment inhibits the production of the protein c-Fos. As c-Fos plays a key role in the development of osteoclasts, which are the specialized cells responsible for bone breakdown and resorption, the authors also show that the vitamin Dmediated inhibition of c-Fos prevented bone loss through a suppression of osteoclast development. In addition, the authors used mice whose ovaries had been removed, in a more "human-like" model of osteoporosis, to screen for other vitamin Dlike agents with c-Fossuppressing activity. They identified a new vitamin Drelated compound (DD281) that could prevent bone loss in these mice more potently than the natural vitamin D. These findings clarify how vitamin D helps limit bone resorption in conditions such as osteoporosis, and suggest that synthetic vitamin D analogs, including DD281, may warrant clinical trial to asses their potential in the treatment of osteoporosis and other related disorders of bone resorption.


'"/>

Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
19-Jan-2006


Page: 1

Related medicine news :

1. Vitamin D supplements may offer cheap and effective immune system boost against TB
2. Vitamin D supplements should be given to Asian children for two years from birth
3. Vitamin A deficiency linked to major intestinal surgery
4. Vitamin D and calcium supplements have varied effects on breast cancer risk
5. Vitamin D targets thrombosis in cancer patients
6. Vitamin C depletion correlates with lower body fat, not weight loss during short-term diet
7. Vitamin C and E supplements do not prevent pre-eclampsia in pregnant women at risk
8. Vitamin D inhibits progression of some prostate cancers
9. Vitamin D supplementation during pregnancy could reduce osteoporosis in children
10. Vitamin D can play role in lung health
11. Vitamin D status appears more important than high calcium intake for maintaining calcium metabolism

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2019)... ... 16, 2019 , ... Prominent pianist Paul Cardall will host a “Red Carpet ... 22. Ballard founded O.U.R. in 2013 as the leading organization which undertakes actual extractions ... Homeland Security Special Agent, leads a team of former CIA, Navy Seal and Special ...
(Date:5/15/2019)... , Mass. (PRWEB) , ... May 15, 2019 ... ... leading provider of senior living services in the Northeast, today announced that its ... (Mass-ALA) inaugural Lifetime Achievement Award. Grape was honored for his pioneering efforts over ...
(Date:5/15/2019)... ... May 15, 2019 , ... ... organization in North America for the scientific development, healthcare training and clinical application ... Annual Meeting & Scientific Session. , The event will take place on September ...
(Date:5/14/2019)... PALOS VERDES ESTATES, Calif. (PRWEB) , ... May ... ... guided journal that follows the patient process of nature from seed to bloom, ... and grow. With thoughtful questions, powerful quotes, and illuminating meditations, GROW creates a ...
(Date:5/14/2019)... ... May 14, 2019 , ... ... TX, has been named by Modern Healthcare as one of the nation's Best Places to Work ... been awarded this title, which comes on the heels of being named among ...
Breaking Medicine News(10 mins):
(Date:5/15/2019)... ... May 15, 2019 , ... It is a busy time at ... hub of the latest Wesley community, throughout April and May. , Purchased in 2009 ... on South Hill is now officially home to over 100 residents with more moving ...
(Date:5/14/2019)... (PRWEB) , ... May 15, 2019 , ... ... Right-to-Try and Dietary Supplements , **An FDAnews Webinar**, Wednesday, May 29, 2019, ... dietary supplements, controversies continue as the agency, Congress and the White House feel ...
(Date:5/14/2019)... ... May 14, 2019 , ... ... Smart guidelines into its 2019 programming at Baseball Heaven in an effort to ... implemented into Baseball Heaven’s spring league for the 8U and 9U divisions, impacting ...
Breaking Medicine Technology:
Cached News: