HOME >> MEDICINE >> NEWS
Vitamin D signals to prevent bone loss during osteoporosis

The risk of bone fracture resulting from falls increases as we age due to bone loss and osteoporosis. Physicians have routinely prescribed vitamin D and vitamin Drelated drugs to retard bone loss, but until now, little was known about the specific targets of vitamin D in bone. In a study appearing online on January 19 in advance of print publication in the February 2006 issue of the Journal of Clinical Investigation, Kyoji Ikeda and colleagues from the National Center for Geriatrics and Gerontology in Japan examine mice with severe osteoporosis and show that oral vitamin D treatment inhibits the production of the protein c-Fos. As c-Fos plays a key role in the development of osteoclasts, which are the specialized cells responsible for bone breakdown and resorption, the authors also show that the vitamin Dmediated inhibition of c-Fos prevented bone loss through a suppression of osteoclast development. In addition, the authors used mice whose ovaries had been removed, in a more "human-like" model of osteoporosis, to screen for other vitamin Dlike agents with c-Fossuppressing activity. They identified a new vitamin Drelated compound (DD281) that could prevent bone loss in these mice more potently than the natural vitamin D. These findings clarify how vitamin D helps limit bone resorption in conditions such as osteoporosis, and suggest that synthetic vitamin D analogs, including DD281, may warrant clinical trial to asses their potential in the treatment of osteoporosis and other related disorders of bone resorption.


'"/>

Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
19-Jan-2006


Page: 1

Related medicine news :

1. Vitamin D supplements may offer cheap and effective immune system boost against TB
2. Vitamin D supplements should be given to Asian children for two years from birth
3. Vitamin A deficiency linked to major intestinal surgery
4. Vitamin D and calcium supplements have varied effects on breast cancer risk
5. Vitamin D targets thrombosis in cancer patients
6. Vitamin C depletion correlates with lower body fat, not weight loss during short-term diet
7. Vitamin C and E supplements do not prevent pre-eclampsia in pregnant women at risk
8. Vitamin D inhibits progression of some prostate cancers
9. Vitamin D supplementation during pregnancy could reduce osteoporosis in children
10. Vitamin D can play role in lung health
11. Vitamin D status appears more important than high calcium intake for maintaining calcium metabolism

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/17/2019)... N.J. (PRWEB) , ... September 17, 2019 , ... ... a wide array of services, welcomes Dr. Yevgeniya (Jenny) Gartshteyn to their team ... Medical Center, where she previously held the Clinical Appointment of Assistant Professor in ...
(Date:9/12/2019)... ... September 12, 2019 , ... ... local and national scale in two recent and well-renowned listing publications, the Inc. ... held businesses for the 2019 year. , Dr. Jeffrey Donaldson, CEO and ...
(Date:9/11/2019)... ... 2019 , ... Global Education Group (Global), a division of ... the official accreditor for PAINWeek, the largest US pain conference for frontline practitioners. ... has done for the past ten years. In addition, the Global team introduced ...
(Date:9/11/2019)... ... , ... Autopsies don’t lie. They report the causes of death as ... harms the heart. It increases risks of heart attack and death. Autopsies ... damage occurs. , An August 1, 2019 article in U.S. News ...
(Date:9/11/2019)... ... September 10, 2019 , ... Women’s Excellence is excited ... is location at 32686 Woodward Ave, Suite 103, Royal Oak, MI 48073 in the ... Oak location offers comprehensive women’s health services in a contemporary, spa-like atmosphere. We ...
Breaking Medicine News(10 mins):
(Date:9/17/2019)... ... 17, 2019 , ... Called Muss-Bits (Musical Sensory Substitution Bits) it has also ... Students category. , It was developed by Associate Professor Suranga Nanayakkara and his team ... of two parts. A “sensor bit” that can be placed on or plugged into ...
(Date:9/17/2019)... CHERRY HILL, N.J. (PRWEB) , ... September 17, ... ... of Canal Calem Periodontics located in Moorestown and Medford, NJ, now welcome patients ... team of periodontists strives to save natural teeth whenever possible. When tooth removal ...
(Date:9/17/2019)... ... September 17, 2019 , ... Dr. Arta Farahmand welcomes patients ... An alternative to conventional orthodontics, the Wilckodontics orthodontic system often cuts treatment time ... orthodontics uses brackets and wires that apply constant pressure on the teeth, thus ...
Breaking Medicine Technology:
Cached News: