Warfarin better than aspirin at stroke prevention in elderly people with atrial fibrillation

Warfarin is more effective than aspirin in prevention of stroke in people with a certain type of irregular heartbeat who are aged 75 or over, conclude authors of an Article published in this weeks edition of The Lancet.

Dr Jonathan Mant, University of Birmingham, UK and colleagues did a study (the Birmingham Atrial Fibrillation Treatment of the Aged Study/BAFTA) to determine how warfarin and aspirin affected stroke risk, and whether use of these drugs outweighed the increased risk of bleeding in elderly patients. They studied 973 patients aged 75 years or over (average 81 years), all of whom had atrial fibrillation, a particular type of irregular heartbeat (arrhythmia). Of these patients, 488 were randomised to receive warfarin and 485 to receive aspirin, and were followed up for an average of 2.7 years. The incidence of fatal or disabling stroke (either ischaemic or haemorrhagic), intracranial haemorrhage, and clinically significant arterial embolism were studied in each group.

The researchers found that in the warfarin group, 24 serious events occurred 21 strokes, two intracranial haemorrhages, and one systemic embolus. In the aspirin group, there were 48 serious events 44 strokes, one intracranial haemorrhage, and three systemic emboli. Thus patients taking warfarin were less than half as likely to suffer a serious event (52% lower risk) as those taking aspirin.

They say: We showed that the frequency of stroke, arterial embolism, and intracranial haemorrhage was significantly lower in patients on warfarin than in those on aspirin, adding that their results show that warfarin could safely be used much more widely by older people.

They conclude: We recorded no evidence that anticoagulants [warfarin] were more hazardous than aspirin therapy in this age group, although the study had limited power to detect those differences.

In an accompanying Comment, Dr David Garcia, University of New Mexico, Albuquerque, U

Contact: Dr. Jonathan Mant

Page: 1 2

Related medicine news :

1. Warfarin remains gold-standard for preventing stroke in patients with heart abnormality
2. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
3. Waist-to-hip ratio may better predict cardiovascular risk than body mass index
4. Nonsmall cell lung cancer -- chemotherapy before surgery appears better than surgery alone
5. Stroke in nonvascular atrial fibrillation -- anti-coagulants better than anti-platelet therapy
6. Holograms make for better vision tests
7. Parents of chronically ill kids are helped by better access to federal and employer leave
8. Diabetes professionals join forces to identify gaps in diabetes care and better self care
9. Exploring better ways to determine when to change the course of treatment
10. Gene variations point to why lung cancer drugs work better in Japanese vs. US patients
11. More rib fractures, but better survival rates

Post Your Comments:

(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer ... one of the most popular and least understood books in the Holy Scriptures, Revelation. ... descriptions that have baffled scholars for centuries. Many have tossed it off as mere ...
(Date:10/13/2017)... VA (PRWEB) , ... October 13, 2017 , ... ... of DevOps and Agile Software Development, has been awarded a contract by the ... Blanket Purchase Agreement (BPA) aims to accelerate the enterprise use of Agile methodologies ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the Christian history of ... Brink” is the creation of published author, William Nowers. Captain Nowers and his ... veteran, he spent thirty years in the Navy. Following his career as a ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... are now treating sleep apnea using cutting-edge Oventus O2Vent technology. As ... serious sleep disorder characterized by frequent cessation in breathing. Oral appliances can offer ...
(Date:10/12/2017)... ... October 12, 2017 , ... The ... demand of today’s consumer and regulatory authorities worldwide. From Children’s to Adults 50+, ... to meet the highest standard. , These products are also: Gluten Free, ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... , Oct. 2, 2017  AllianceRx Walgreens Prime, ... formed by Walgreens and pharmacy benefit manager Prime Therapeutics ... new brand, which included the unveiling of new signage ... , as well as at a few other company-owned ... new brand to patients, some of whom will begin ...
(Date:10/2/2017)... , Oct. 2, 2017 The Rebound mobile app ... struggle to reverse the tide of prescription drug addiction. The ... their medicine intake and stepping down their dosage in a ... launch in December 2017; the first 100,000 people to sign ... at http://www.rebound-solution.com/ ...
(Date:9/28/2017)... , Sept. 28, 2017 Cohen Veterans Bioscience ... the use of wearable and home sensors for real-time ... Early Signal Foundation, a nonprofit organization focused on disruptive ... provide an affordable analytical system to record and integrate ... ...
Breaking Medicine Technology:
Cached News: