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What is the best way to reduce birth defects caused by the acne drug isotretinoin?

Isotretinoin is a very effective treatment for severe acne, a condition which can be physically, emotionally, and socially disabling. But the drug can also cause severe birth defects if it is taken by pregnant women. What is the best way to prevent pregnant women from taking the drug, and to prevent women taking it from getting pregnant?

A debate article in PLoS Medicine considers the pros and cons of a new Internet-based system, called iPLEDGE (www.ipledgeprogram.com), which tries to tries to ensure that the drug is dispensed only when there is documentary proof that the patient is not pregnant and is using two forms of birth control.


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Contact: Andrew Hyde
press@plos.org
44-122-346-3330
Public Library of Science
20-Nov-2006


Page: 1

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