HOME >> MEDICINE >> NEWS
When preventing pre-eclampsia, a little carbon monoxide goes a long way

Kingston, Ontario -- Researchers have shown that carbon monoxide may prevent the placental cell death caused by oxidative stress injury, possibly averting the risks of pre-eclampsia. The report by Bainbridge et al., "Carbon monoxide inhibits hypoxia/reoxygenation-induced apoptosis and secondary necrosis in syncytiotrophoblast," appears in the September issue of The American Journal of Pathology.

Pre-eclampsia, a form of pregnancy-associated hypertension, affects 5-7% of pregnancies and poses serious risks for both mother and child. If maternal blood vessels at the placental barrier fail to remodel and adapt to the changing nutrient/oxygen needs of the growing fetus, the maternal blood pressure rises in an effort to improve nutrient delivery. This leads to oxidative stress and damage to the placenta, specifically to the syncytiotrophoblast. When syncytiotrophoblast cells die, they are released into the maternal circulation, initiating a cascade of inflammation that can damage maternal organs.

Interestingly, mothers who smoke cigarettes during pregnancy have a 33% decreased risk of developing pre-eclampsia compared to nonsmokers. New research questions whether the carbon monoxide found in cigarette smoke, and subsequently carried in a smoking mother's blood, may be the cause. Carbon monoxide, which is produced naturally by the body at low levels, possesses vessel-relaxing and cytoprotective activities that may prevent syncytiotrophoblast cell death and the resulting injury to fetus and mother.

Dr. Graeme Smith and colleagues examined this hypothesis using tissue from term human placentas obtained following elective caesarian section from nonsmoking, low-risk women. When cultured tissues were exposed to oxidative stress (hypoxia and re-oxygenation), syncytiotrophoblast cell death occurred. However, when tissues were treated with carbon monoxide, at levels similar to those found in blood of smoking mothers, cell death was significantly r
'"/>

Contact: Audra Cox
acox@asip.org
301-634-7409
American Journal of Pathology
1-Sep-2006


Page: 1 2

Related medicine news :

1. Doctors have key role in preventing and detecting child neglect and abuse
2. When it comes to preventing amputation in diabetics, site, not size, matters
3. Mayor of New York proposes preventing 100 million deaths from tobacco
4. Managing and preventing obesity in Canadian adults and children
5. Opening windows may be the best way of preventing transmission of airborne infection
6. Opening windows effective way of preventing transmission of TB
7. MRSA surveillance, rapid screening, and hospital hygiene key to preventing future transmission
8. Warfarin remains gold-standard for preventing stroke in patients with heart abnormality
9. Paclitaxel-releasing stent more effective than radiation therapy for preventing restenosis
10. Low-tech garment holds promise in preventing maternal death related to childbirth
11. Seasonal intermittent treatment highly effective for preventing malaria in children under five

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/20/2017)... ... September 20, 2017 , ... On Thursday, the Triangle ... Work in the Research Triangle for 2017. , Winners were chosen based on ... meet a threshold in employee participation--a percentage that varies based upon the size ...
(Date:9/20/2017)... ... 20, 2017 , ... Doctors on Liens has added the medical group Bones ... working on a personal injury lien basis. Founded by Dr. Wayne Cheng, MD and ... vast experience with orthopedic injuries to patients in the Inland Empire. , Bones and ...
(Date:9/20/2017)... ... September 20, 2017 , ... ... much-anticipated fall event , Look Awesome This Autumn with CoolSculpting®. Scheduled for ... pricing and refreshments. , Mirror Mirror Beauty Boutique is Houston’s largest ...
(Date:9/20/2017)... ... September 20, 2017 , ... Announced that Clear ... commercial support services market) has entered into an agreement on September 1, 2017 ... The PGSD is the first private Dental School to launch an online, accredited ...
(Date:9/20/2017)... ... ... Compliancy Group is proud to announce that its proprietary ... long-time client pass their Department of Health and Human Services (HHS) Office for ... the help of the Compliancy Group's Audit Response Program™, not a single client ...
Breaking Medicine News(10 mins):
(Date:9/7/2017)... , Sept. 7, 2017 NuvoAir ... Smart Spirometer, announced today a partnership with Novartis Pharma AG ... solidifies NuvoAir,s position as the leading mobile spirometry platform and ... patients. ... test ...
(Date:9/6/2017)... ANTONIO , Sept. 6, 2017  Robert G. ... a Pinnacle Professional Member in recognition of his contributions ... Szewc serves as a Nephrologist at the practice of ... emergency medicine, kidney care and hypertension solutions. He has ... 20 years of career experience, as well as expertise ...
(Date:9/6/2017)... -- NeuroRx, a clinical stage biopharma company developing the first ... been granted Fast Track status by the US Food and ... followed by NRX-101 (D-cycloserine + lurasidone). The company will shortly ... therapy targeting patients who are admitted to Emergency Departments with ... ...
Breaking Medicine Technology:
Cached News: