Why good cells go bad in progression of MS

Scientists have pinpointed a chemical messenger that frees some white blood cells from the body's normal constraints, allowing the cells to act like renegades that could damage nerves in the central nervous system. The work, to be published in the July 15 issue of the Journal of Immunology and just published on-line, helps explain one of the fundamental mysteries of multiple sclerosis (MS).

The scientists discovered that a chemical messenger found at high levels in MS patients allows some immune cells known as T- effector cells to evade normal regulation. Instead, the cells bypass their usual gatekeepers and could become active in the body's tissues, including the brain and spinal cord. Scientists believe that during MS, renegade T-effector cells damage the myelin coating that covers nerve cells, causing the disease's symptoms. While another subset of white blood cells called T-regulatory cells normally control the activation of T-effector cells, investigators found that the chemical messenger interleukin-12 or IL12 allows some cells to sidestep that regulation and run amok.

"Normally effector T cells are under strict control as they circulate through the blood stream in order to prevent unnecessary inflammation that could be harmful to otherwise healthy tissues," says Benjamin Segal, M.D., the neurologist who led the University of Rochester study. "However, occasionally they escape the body's suppression system. We're learning how they do that."

In the 1990s, while working in the laboratory of Ethan Shevach, M.D., at the National Institute of Allergy and Infectious Diseases, Segal was one of the first scientists to show that IL12 could be important in autoimmune diseases like MS. He showed that the molecule empowers CD4+ T cells to enter the central nervous system, where they don't belong, and attack myelin. He has also shown that mice without the IL12 gene are completely protected against an MS-like disease, and that ordinary mice can be pr

Contact: Tom Rickey
University of Rochester Medical Center

Page: 1 2 3

Related medicine news :

1. New cause of tamoxifen resistance in breast cancer cells discovered at Lombardi
2. Study says normal but out-of-control enzyme may be culprit that signals some cells to become cancer
3. New algorithm matches any tumor cells to best possible anti-cancer treatments
4. Aging stem cells in mice may hold answers to diseases of the aged, Stanford study finds
5. Loss of stem cells correlates with premature aging in animal study
6. UCLA researchers develop new nanomaterials to deliver anti-cancer drugs to cells
7. Trial shows circulating tumor cells predict how prostate cancer patients do with chemotherapy
8. Stanford researchers track human stem cells transplanted into rat brain
9. Nurse cells make life and death decisions for infection-fighting cells
10. Adult brain cells rediscover their inner child
11. Stem cells provide clues to cancer spread

Post Your Comments:

(Date:8/28/2020)... ... ... Integrated Viral Protection (IVP Air) today announced that the True North Classical ... Indoor Air Protection System that is the first system designed and proven to catch ... the filtration system on September 8th. , The IVP Air S1 model is ...
(Date:8/28/2020)... ... August 28, 2020 , ... ... strongly suggest that obese individuals are at an increased risk of developing severe ... likely to catch COVID-19; however, because the same organ systems that the coronavirus ...
(Date:8/27/2020)... ... August 27, 2020 , ... The team at ... aesthetic and wellness retreat. The practice is centered on results and providing the ... , Designed to be a sanctuary for total body renewal and aesthetic ...
(Date:8/26/2020)... ... August 26, 2020 , ... Smile Brands Inc. ... Inclusion Online Forum, leading a session entitled, “A CEO Guide for Delivering and ... magnitude designed to bring together the world’s leading diversity and inclusion executives, HR ...
(Date:8/26/2020)... ... , ... In “ U.S. Health Insurance Coverage in 2020: A Looming Crisis ... aged 19-64 about their healthcare coverage. The survey interviewed 4,272 adults over a period ... June 4, more than two months into the outbreak and subsequent economic displacement. ...
Breaking Medicine News(10 mins):
(Date:9/3/2020)... HANOVER, Md. (PRWEB) , ... September 03, 2020 ... ... in National Sickle Cell Awareness Month in September by holding a series of ... was designated by Congress to focus attention on the need for research and ...
(Date:9/3/2020)... ... September 03, 2020 , ... Q&J Face Masks ... ), an aerosol and engineering lab, conducted tests on Q&J’s personal face mask ... virus than many other masks. Q&J face masks have both mechanical filtering and ...
(Date:9/3/2020)... ... 03, 2020 , ... Using Analysis of Variance — A Practical Approach:, Perform ... p.m.-3:00 p.m. EDT, https://www.fdanews.com/anova , How much would it help one’s Quality ... become one in 90 minutes, one can master a powerful statistical technique in that ...
Breaking Medicine Technology:
Cached News: