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Women report various symptoms after stopping hormone therapy

ively, with these symptoms at baseline. Moderate or severe vasomotor symptoms were nearly 6 times more likely, and pain or stiffness symptoms more than twice as likely, in the former CEE + MPA group than in the placebo group. Both vasomotor and pain or stiffness symptoms were more likely in women with these symptoms at baseline.

"Short term use of CEE + MPA may only alleviate symptoms temporarily for many women, including older women, who may experience a return of menopausal symptoms after stopping MHT. A wide range of lifestyle and medical strategies to manage symptoms may help. Further testing of the efficacy of these management strategies for women whose symptoms recur after discontinuing short-term MHT is warranted," the authors conclude.

(JAMA. 2005;294:183193. Available pre-embargo to the media at www.jamamedia.org.)

Editor's Note: For funding/support and financial disclosure information, please see the JAMA article.

Editorial: Some Surprises, Some Answers, and More Questions About Hormone Therapy

In an accompanying editorial, Diana B. Petitti, M.D., of Kaiser Permanente Southern California, Pasadena, discusses the findings in the study by Ockene et al.

"Middle age is a time of change physically, psychologically, socially, and economically, and these changes affect the body and the mind. Aches, pains, fatigue, and some other symptoms that are reported frequently by middle-aged women may be a consequence of simple (or not so simple) aging. Delineation of which symptoms are truly due to ovarian aging and which are due to general aging would permit more specific symptom management strategies. Hormone therapy could be used for the symptoms resulting from a decline in natural hormone levels. Treatments that carry minimal risk, including self-management strategies and positive changes in lifestyle, could be recommended for women with other symptoms."

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Contact: Alison Duffy
508-856-2000
JAMA and Archives Journals
12-Jul-2005


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