HOME >> MEDICINE >> NEWS
Wrinkled membranes create novel drug-delivery system

A University of Illinois scientist studying how membranes wrinkle has discovered a novel system for on-demand drug delivery.

Sahraoui Chaieb, a professor of mechanical and industrial engineering, has created temperature-sensitive capsules that can release drugs on demand. The capsules, which can range in size from 10 to 100 microns, can be tuned to deliver drugs at different rates. Chaieb reports his findings in the Feb. 17 issue of the journal Physical Review Letters.

To make the capsules, Chaieb begins by confining a drug inside lipid bilayer membranes. Some of the lipids are then "sewn together" through a polymerization process. Cooling the capsules by 10 degrees Celsius causes the capsules to crumple and collapse like deflated beach balls, releasing the drug.

"The release rate can be controlled by the amount of wrinkling that occurs," said Chaieb, who also is a professor of bioengineering and a researcher at the Beckman Institute for Advanced Science and Technology. "And the amount of wrinkling is dependent upon the degree of membrane polymerization that took place."

One problem that remains is how to cool the capsules without harming the surrounding tissue. The solution, Chaieb said, might lie in newly discovered nanoparticles that can be chilled through magnetic cooling.

Chaieb and colleagues at Illinois are exploring ways to coat the capsules with the nanoparticles. When exposed to a magnetic field, the nanoparticles would cool down and remove heat from the capsules. The capsules would then wrinkle and release the drug.


'"/>

Contact: James E. Kloeppel, Physical Sciences Editor
kloeppel@uiuc.edu
217-244-1073
University of Illinois at Urbana-Champaign
13-Feb-2006


Page: 1

Related medicine news :

1. RAND, Health Dialog form alliance to create tools to evaluate health-care quality and efficiency
2. Spanish project AmIVital creates intelligent communication devices for elderly and disabled people
3. ASU, Walter Reed researchers create prosthesis of the future
4. Head and neck cancer vaccine targets proteins to create immune response
5. Scientists create dual-modality microbeads to improve identification of disease biomarkers
6. St. Jude, El Salvador create research ethics committee
7. Bacteria could make new library of cancer drugs that are too complex to create artificially
8. NCI creates network of Clinical Proteomic Technology Centers for cancer research
9. UCSD researchers create roadmap to integrin activation
10. Young brainy students create world first
11. Baylor Institute for Immunology research receives $3 million grant to create cancer vaccines

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Wrinkled membranes create novel drug delivery system

(Date:5/22/2015)... 2015 In efforts to offer full ... containing particular muscles stretches has been a large focus ... stretches now complete, Chunk Fitness envisions a mid-June launch ... filmed and released at a later point in time. ... http://www.chunkfitness.com/stretches . , About the Company: Chunk Fitness ...
(Date:5/22/2015)... May 22, 2015 Pro3rd Impression ... designed exclusively for Final Cut Pro X. Pro3rd Impression's ... design. , Intuitive on-screen-controls allow users to customize ... Reflections, colors, layouts, and much more can be edited ... , Pro3rd Impression comes packed with 30 ...
(Date:5/21/2015)... Los Angeles, California (PRWEB) May 21, 2015 ... Angeles area at the Hilton Hotel in San Gabriel on ... heard over and over again from men and women who ... can find the right partner." , "Many singles think that ... right person. The seeker would go from one relationship to ...
(Date:5/21/2015)... 21, 2015 The Johns Hopkins Alliance ... Maryland, Baltimore Commercial Advisory Board has selected a research ... System as one of two $50,000 Abell Foundation Award ... research, known as Anklebot. Developed by the VA ... with the University of Maryland School of Medicine and ...
(Date:5/21/2015)... How do you stop head lice epidemics ... and school administrators, but a Miami Lice Removal Company, Lice ... southern Florida, is devising new ways to stop the spread. ... you, the first step is education and prevention. Despite the ... and how they spread are still widely misunderstood. Many continue ...
Breaking Medicine News(10 mins):Health News:Developers at Pixel Film Studios Release Pro3rd Impression for Final Cut Pro X. 2Health News:Bestselling Author Sheds Light on Why Modern Dating is Hurting People's Chances of Finding a Lasting Relationship 2Health News:VA Maryland Health Care System Researchers Selected for Abell Foundation Innovation Award 2Health News:VA Maryland Health Care System Researchers Selected for Abell Foundation Innovation Award 3Health News:Local Lice Removal Company Partners with Schools to Combat Head Lice in the Classroom as Increase in Number of Cases Reported in May. 2
(Date:5/21/2015)... 2015 Research and Markets( http://www.researchandmarkets.com/research/pw67sw/xray_market ) has announced ... Size, Share, Growth, Trends and Forecast 2014 - 2022" ... held the largest share of 34.6% of the ... Pacific and Europe . ... the U.S. and Canada that have ...
(Date:5/21/2015)... Kalifornien, und KOPENHAGEN, Dänemark, 21. Mai 2015 ... ein Weltmarktführer bei der klinischen und kommerziellen ... man werde im Rahmen der weltweiten Kapazitätserweiterungsstrategie ... 14.000 Liter Produktionskapazität erweitern. Logo ... erhalten durch das innovative Einweg Bioreactor 6Pack ...
(Date:5/21/2015)... BETHESDA, Md. , May 21, 2015 /PRNewswire-USNewswire/ ... an open innovation competition designed to bring promising ... the Heritage Provider Network (HPN) in collaboration with ... Center for Advancing Innovation (CAI).  The winning teams ... models and live pitches and will move forward ...
Breaking Medicine Technology:X-Ray Market: Global Industry Analysis 2014 - 2022 2CMC Biologics erweitert GMP-Produktionskapazität in Europa 2CMC Biologics erweitert GMP-Produktionskapazität in Europa 3Neuro Startup Challenge selects 13 winning teams to launch startups for unlicensed NIH technologies to improve brain health 2Neuro Startup Challenge selects 13 winning teams to launch startups for unlicensed NIH technologies to improve brain health 3Neuro Startup Challenge selects 13 winning teams to launch startups for unlicensed NIH technologies to improve brain health 4
Cached News: