HOME >> MEDICINE >> NEWS
Wrinkled membranes create novel drug-delivery system

A University of Illinois scientist studying how membranes wrinkle has discovered a novel system for on-demand drug delivery.

Sahraoui Chaieb, a professor of mechanical and industrial engineering, has created temperature-sensitive capsules that can release drugs on demand. The capsules, which can range in size from 10 to 100 microns, can be tuned to deliver drugs at different rates. Chaieb reports his findings in the Feb. 17 issue of the journal Physical Review Letters.

To make the capsules, Chaieb begins by confining a drug inside lipid bilayer membranes. Some of the lipids are then "sewn together" through a polymerization process. Cooling the capsules by 10 degrees Celsius causes the capsules to crumple and collapse like deflated beach balls, releasing the drug.

"The release rate can be controlled by the amount of wrinkling that occurs," said Chaieb, who also is a professor of bioengineering and a researcher at the Beckman Institute for Advanced Science and Technology. "And the amount of wrinkling is dependent upon the degree of membrane polymerization that took place."

One problem that remains is how to cool the capsules without harming the surrounding tissue. The solution, Chaieb said, might lie in newly discovered nanoparticles that can be chilled through magnetic cooling.

Chaieb and colleagues at Illinois are exploring ways to coat the capsules with the nanoparticles. When exposed to a magnetic field, the nanoparticles would cool down and remove heat from the capsules. The capsules would then wrinkle and release the drug.


'"/>

Contact: James E. Kloeppel, Physical Sciences Editor
kloeppel@uiuc.edu
217-244-1073
University of Illinois at Urbana-Champaign
13-Feb-2006


Page: 1

Related medicine news :

1. RAND, Health Dialog form alliance to create tools to evaluate health-care quality and efficiency
2. Spanish project AmIVital creates intelligent communication devices for elderly and disabled people
3. ASU, Walter Reed researchers create prosthesis of the future
4. Head and neck cancer vaccine targets proteins to create immune response
5. Scientists create dual-modality microbeads to improve identification of disease biomarkers
6. St. Jude, El Salvador create research ethics committee
7. Bacteria could make new library of cancer drugs that are too complex to create artificially
8. NCI creates network of Clinical Proteomic Technology Centers for cancer research
9. UCSD researchers create roadmap to integrin activation
10. Young brainy students create world first
11. Baylor Institute for Immunology research receives $3 million grant to create cancer vaccines

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Wrinkled membranes create novel drug delivery system

(Date:7/31/2015)... (PRWEB) , ... July 31, 2015 , ... Ticket Down is a reputable source of ... the MGM Grand Garden Arena. Fans of every genre of music will have an ... 18th, the first day of the festival, the following artists will perform: Sam Smith, ...
(Date:7/31/2015)... CA (PRWEB) , ... August 01, 2015 , ... Super Bowl 50 will ... National Football League’s biggest day each year is the Super Bowl. In the two weeks ... takes place from the host venue. The 2016 Super Bowl game will mark the 50th ...
(Date:7/31/2015)... ... July 31, 2015 , ... Recently touted by Becker’s Healthcare ... health analytics , Jvion continues to disrupt the predictive analytic and big data ... patient and population level illness to drive prevention and better health outcomes. Most ...
(Date:7/31/2015)... ... July 31, 2015 , ... Sculpted Contours Luxury Medical Aesthetics announces the arrival ... Zeltiq Aesthetics released this new applicator in the United States as an upgrade to ... thighs. The original applicator required a 2 hour treatment time. The new ...
(Date:7/31/2015)... ... July 31, 2015 , ... Facebook, Twitter, Linkedin and blogs ... social media profiles to better connect with the public. The agency website at ... share insights and opinions. The Rally Insurance Group, Inc.’s pledge to provide effortless ...
Breaking Medicine News(10 mins):Health News:Cheap 2015 iHeartRadio Music Festival Tickets in Las Vegas at MGM Grand Garden Arena: Ticket Down Slashes Ticket Prices on the iHeart Radio Music Festival in Vegas 2Health News:Cheap 2015 iHeartRadio Music Festival Tickets in Las Vegas at MGM Grand Garden Arena: Ticket Down Slashes Ticket Prices on the iHeart Radio Music Festival in Vegas 3Health News:Cheap 2016 Super Bowl Tickets at Levi's Stadium: Ticket Down Slashes Ticket Prices on Super Bowl 50 Tickets in Santa Clara, CA at Levi's Stadium 2Health News:Jvion Showcased as Leader in the Predictive Analytic Market 2Health News:Cooler Coolsculpting in Atlanta: Treatments Now Twice As Fast 2Health News:Cooler Coolsculpting in Atlanta: Treatments Now Twice As Fast 3Health News:Rally Insurance Group, Inc. Connects to Customers Through Re-branded Social Media Profiles 2
(Date:7/30/2015)... 30, 2015 PTC Therapeutics, Inc. (NASDAQ: ... financial results for the second quarter ending June 30, ... fronts across the organization.  We are excited to be ... clinical trial ever conducted with topline results expected in ... Executive Officer, PTC Therapeutics, Inc. "Translarna is now commercially ...
(Date:7/30/2015)... , July 30, 2015  Cleveland Clinic President ... keynote address last month that industry is compelled to ... to gain the efficiencies—and develop the transformational innovations -- ... Barsoum,s comments were preceded by Doug Kohrs , ... OMTEC moderator, who stressed that industry must add "episode ...
(Date:7/30/2015)... New York , July 30, 2015 ... of its latest report titled, "Continuous Glucose Monitoring Systems ... 2020". According to the report, the global continuous glucose ... in 2014 and is expected to reach US$ 788.4 ... the forecast period, 2015 to 2020. Global ...
Breaking Medicine Technology:PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 2PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 3PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 4PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 5PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 6PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 7PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 8PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 9PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 10Orthopaedic Surgery Reimbursement Shifts to Episode of Care 2Global Continuous Glucose Monitoring (CGM) Systems Market: Transmitters and Monitors Most Dominant Segment, Says Future Market Insights 2Global Continuous Glucose Monitoring (CGM) Systems Market: Transmitters and Monitors Most Dominant Segment, Says Future Market Insights 3Global Continuous Glucose Monitoring (CGM) Systems Market: Transmitters and Monitors Most Dominant Segment, Says Future Market Insights 4
Cached News: