NEW YORK, November 17, 2005 - Three young investigators who have made major accomplishments in cancer research will be the recipients of the 2005 Paul Marks Prize for Cancer Research and will share a $150,000 award, announced Memorial Sloan-Kettering Cancer Center (MSKCC).The winners are Tyler E. Jacks, of the Massachusetts Institute of Technology (MIT) and the Howard Hughes Medical Institute (HHMI), who has advanced our understanding of the pathogenesis of cancer; Scott W. Lowe, of Cold Spring Harbor Laboratory (CSHL) and the HHMI, who studies how genes influence the response to chemotherapy; and Jeff Wrana, of the University of Toronto and the Samuel Lunenfeld Research Institute (SLRI), who is being recognized for his work analyzing the impact of cell-cell communication on tumor development.

The prize, named after Paul A. Marks, President Emeritus of MSKCC, recognizes significant contributions to the basic understanding and treatment of cancer by scientists no more than 45 years old at the time they are nominated. The winners were selected by a committee chaired by Jeffrey M. Friedman, a professor at The Rockefeller University and an HHMI investigator.

"While still in relatively early stages of their careers, the three winners already are leaders in their respective fields of research," said Dr. Friedman. "Each has made significant contributions to our understanding of the genes, signaling pathways, and processes that regulate cell proliferation and lead to the formation of tumors, their spread, and their response to treatment. The selection committee is confident that these three young scientists will continue to play key roles in cancer research in the future."

Building a better mouse

Dr. Jacks has taken novel approaches to creating better, more accurate models of a variety of human cancers in mice. Much of his research has focused on the oncogene K-Ras, which is implicated in 30 percent of non-small cell lung cancers
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Contact: Esther Napolitano
napolite@mskcc.org
212-639-2573
Memorial Sloan-Kettering Cancer Center
17-Nov-2005

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