Tag: "activators" at biology news

Hormone Activators Stimulate Skin Growth In Fetal Rats Suggesting Possible Skin Treatment For Premature Infants

...UC San Francisco scientists haveidentified hormone activators that stimulate skin development in premature rats....rs of hormones,accelerate barrier formation. Some activators for hormone receptors, PPAR alphaand FXR, are generated in the skin itself, suggesting the process o...

Scientists Discover New Players On The Gene-Activation Team

... the experiments we've done show thattranscription activators and HAT complexes bind to each other," Workmanexplains. Some of his other experiments showed that this binding causesthe HAT complexes to acetylate only those nucleosomes that are bound bythe transcription activator. "This research changes and compli...

Newly Identified Molecular Mechanism Could Lead To New Approaches For Preventing Heart Attack, Stroke

... plateletsunder experimental conditions, but other activators are known, and the questionof what happens when platelets in living animals or people cannot respond tothrombin has not been answered. We suspect thrombin plays a critical role, butthat role has yet to be proven conclusively." Co-investigato...

Idun Pharmaceuticals Identifies Cell Type And Molecular Pathway Involved In TransplantationRelated Liver Damage

...n'sdrug discovery programs focus on small molecule activators of apoptosis forapplications in cancer....

Gene Discovery Paves Way For Preventing Deadly Bacterial Shock

...ance made bybacteria that is among the most potent activators of the body's defense againstinfections. Its cloning culminated a five-year effort in which the scientistsmapped a minute region of the mouse genome, identified every gene in the region,and then pinpointed Tlr4. The project was intensely competitive ...

Rockefeller University Scientists Receive Prestigious Awards For Cancer Research

...y hundreds or thousands of gene- and cell-specific activators thatregulate their function on target genes. Dr. Roeder explained that over the years he has become increasingly interestedin the applications of his research. "We need not only to understand themechanisms underlying normal gene expression, but to r...

Possible cause and treatment for shock uncovered by UC San Diego bioengineers

...death. These symptoms are induced when activators in the blood stream turn on various cardiovascular...ong). These enzymes produce and release dangerous activators into the blood stream, initiating a cascade of events leading to multiple organ failure." ...

The silence of the clones: new link between DNA replication and 'silent' chromosome architecture

...t are generally more accessible to transcriptional activators . Now, Bruce Stillman and his colleagues at Cold Spring Harbor Laboratory have demonstrated how a set of proteins work in concert to duplicate both the basic sequence of DNA as well as silenced states of chromatin structure. The findings, published ...

Crystal structure of protein interaction could lead to new drugs against cancer

...ining the structures of other G proteins and their activators to build up a set of data to which rational drug design can be applied. The structures will highlight points of protein interaction between the G proteins that may be targeted pharmacologically. Co-authors of the Nature report are American Cancer S...

DNA arrays decipher genome's master switches

...activators. In humans, there are about a 1000 such activators controlling important functions in life, including cell growth and development. Some of the best known of these switchesthe p53 protein, for exampleare those that play a role in cancer. Others play a role during development, designating which cells b...

Key enzyme responsible for fat development discovered

...hers to develop a cancer therapy by blocking these activators have so far proved disappointing, said Zena Werb, ...ientists' surprise, it showed too that plasminogen activators tPA and uPA -- thought to be crucial to this process -- are in fact unnecessary. The scientists foun...

New light shed on vitamin A's role in the body's natural defenses

... (LPS) and cytokine induced signal transducers and activators of transcription-1 (STAT-1) activation and expression in human THP-1 monocytic cells." The co-authors are Yifan Ma, a graduate fellow and research assistant, and Dr. Ross. In the Penn State experiments, human cells, called macrophages, that are the ...

Understanding lens development

...a different, but equally important, family of gene activators that are involved in a variety of developmental processes such as sex determination, cartilage formation, and lymphocyte differentiation. This discovery of coordinated Pax6/Sox2 action introduces the possibility of further Pax/Sox protein interaction...

Researchers build diagram of cell cycle clock

...e of the cell cycle also activates transcriptional activators in the next stage of the cell cyclecreating a series of switches connected in a circular network. "It makes elegant sense that the cell cycle is controlled through a circular network, but that wasnt anticipated. We now see that the network that contr...

Study pinpoints mechanism behind tamoxifen side effect

...e cell division, while others restrain it. If more activators than repressors are attracted to the estrogen receptors, growth is stimulated; if more repressors than activators, growth is restrained. The new study offers convincing evidence that the theory is right. Brown and Yongfeng Shang, PhD, the papers lead...

Australian frog is first to make its own chemical weapons

...leading to the discovery of batrachotoxins. Potent activators of sodium ion channels, these alkaloids are now being used to explore key processes in the human body, including nerve conduction, muscle contraction and heart function. The pseudophrynamines were found to be potent blockers of nicotinic receptors, ...

Wrong proteins targeted in battle against cancer?

...e they are both less numerous than other signaling activators and are at a focal point of many cancer pathways," says Darnell. "Like kicking Achilles in the heel, striking at these targets would constitute a more global approach to fighting cancer." In the past, drug developers in search of cancer therapeutics...

B-vitamins prove effective in relieving chronic pain

...- inhibition of thermal hyperalgesia. B1 and the activators and inhibitors of cGMP-PKG pathways did not alter the foot withdrawal latency in unoperated control rats. Summary The present studies demonstrate that spinal application as well as intraperitoneal injection of vitamin B1, B6, B12 their combinatio...

JCI table of contents, July 1 2003

... targeting VEGFR-1 with additional pharmacological activators may also control vessel degeneration in ROP and other retinopathies. TITLE: Selective stimulation of VEGFR-1 prevents oxygen-induced retinal vascular degeneration in retinopathy of prematurity AUTHOR CONTACT: Lois E. H. Smith The Children's Hospita...

Protecting vessel loss in the eyes of premature infants

... targeting VEGFR-1 with additional pharmacological activators may also control vessel degeneration in ROP and other retinopathies....

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