Green Tea Ingredient Can Kill Cancer Cells
...ities to interfere with cancer development through administration of purified polyphenolic derivatives, said Mukhtar. "Green tea appears to be potentially an ideal agent for chemoprevention." The investigators feel that the chemoprevention properties of green tea need to be evaluated in human trials. Tea consumpt...Regulator Of Fat Thermostat Found
...ant professor ofpsychiatry and of psychology, oral administration of a steroid hormone for fourdays doubled the amount of circulating leptin in 52 patients. Levels of leptin,a product of fat cells, climbed even higher in obese subjects. The results werepublished in the October 1997 issue of the Journal of Clinical ...Johns Hopkins Scientists Designing Compounds To Fight Malaria
..., perhaps, is the fact that they are active byoral administration so you can not only administer them byinjection, y...form of malaria, called cerebral malaria, theearly administration of medicine could be the difference betweenlife and death. That form of the disease can induce coma ......ent of the first 24-h urine sample collected after administration of stable calcium isotopes. Bone mineral of the total body and lumbar spine was measured by dual-energy X-ray absorptiometry and quantitative computerized tomography, respectively. Twenty-four--hour urine and fasting serum samples were analyzed for c...Inhibitor Shows Potential To Protect Infant Brain
...ase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury. Journal of Clinical Investigation, 101(9), May 1998. The study was funded by the National Institute of Nervous Disorders and Stroke, the National Institute on Aging, the Spinal Cord Research...Biosphere Lessons Can Be Applied To Space, Former Crew Co-Captain Says
...ed thearchitectural division operations, financial administration and cost controlfrom 1987 to 1991 for Space Biospheres Ventures, the company that built andoperated Biosphere 2. In addition to publishing papers on the agricultural systems ofBiosphere 2, she has published a cookbook, Eating In: From the Fie...Cancer Test May Offer High-Risk Groups Quick, Affordable Screening For Tumors
...rusilow believes it may bepossible to adapt it for administration through bacterial inhibition assays, aninexpensive technique commonly used to screen newborn babies for phenylketonuriaand other diseases. "We're still relatively early in the development, but I'm confident thatthe test can be implemented in ......h. "This is the first example of theintramuscular administration of a gene therapy vector resulting in sustainedimp...atients with hemophilia B." A single intramuscular administration of an AAV vector containing the gene forfactor IX was given. The animals showed long-term productio...Vaccine Kills Spreading Cancer In Animal Model
...proaches to overcome thisproblem, including direct administration of the E7 gene with a gene gun,so-called "naked" DNA vaccination. Plans also are being made for an initialhuman trial of the current vaccine. Other study authors were Wu, Edwin Chang, Ken-Yu Lin, Robert Kurman, andDrew Pardoll. --JHMI-- Jo...Taking The "Ouch" Out Of Needles: Arrays Of "Microneedles" Offer New Technique For Drug Delivery
...ng pain. Arrays of the microneedles could improve administration of existingmedications, allow development of new therapeutic compounds and open the doorfor microprocessor-based systems fordelivering drugs continuously or in response to body needs. Produced withfabrication techniques originally developed for the m...Ligand Scientists Discover Tissue-Selective Female Hormone Mimics
...s and the ability tomaintain pregnancy despite the administration of the progesterone blockermifepristone--confirmed that the Ligand compounds act like naturally occurringprogesterone, but at doses lower than the MPA standard, particularly in thepregnancy maintenance assay," said Todd Jones, Ph.D., Director of Medi...Combining Angiostatin With Radiation Enhances Anti-Cancer Effects Of Each
...are,could be dramatically improved by simultaneous administration of relativelysmall doses of angiostatin," said Ralph Weichselbaum, M.D., professor andchairman of radiation oncology at the University of Chicago and director of thestudy. "This combination could make radiation much more effective at providinglocal ...... human cell types. In a preclinical vaccinemodel, administration of these envelope proteins resulted in protection from HCV challenges and correlated with the presence of antibodies that inhibited the binding of E2 to human cells. Confirmation ofvirus binding to CD81 was established using a variety of sophisticat...Calcium Channel Blocker Slows Hardening Of Arteries In Some Key Arteries, But Not Others
... The investigators had hoped to show that regular administration ofamlodipine over three years would reduce the progress of atherosclerosis insegments of the coronary arteries with less than 30 percent blockage, asmeasured by heart catheterization (also known as angiography). However, amlodipine appeared t...Researchers Externally Regulate Gene Implanted In Brain
... on brain tissue during three weeks of doxycycline administration in theanimals' drinking water revealed highly significant reductions in the reportergene's protein production. Protein production resumed during the weeks withoutthe drug, demonstrating that the gene could be regulated in the brain byadministration o......monella into mice and swine caused no deaths,while administration of wild-type bacteria produced mortality in all of the micewithin four days and 90 percent of the treated swine within 28 days. Vion Pharmaceuticals, Inc. is a biopharmaceutical company engaged in thediscovery, development and commercialization of no...Gene Therapy Incorporates Molecular Rheostat For Controlled, Long-Term Drug Delivery
...ood cells in the bloodstream. Conversely, stopping administration of rapamycinshut down production of Epo. The effects of the treatment were tracked for sixmonths in mice and three months in monkeys. Epo was chosen as a demonstration gene for the new drug delivery systembecause it is a therapeutically signi...Encouraging Results In Preclinical Studies Of Parkinson's Disease Gene Therapy
... to eat anddrink was restored following the single administration of gene therapy." In the published experiments, mice dependent upon daily injections of L-dopa fortheir survival, were injected with AAV vectors carrying the tyrosine hydroxylaseand GTP cyclohydrolase I genes directly to the striatum, one of the prin...Folic Acid Lowers Risk Of Cardiovascular Disease
...rch." Since the 1970s, researchers have known that administration of folic aciddramatically protects against the development of birth defects like spina bifidain humans. More recent evidence has suggested a correlation between high levelsof homocysteine in blood and an increased risk of cardiovascular disease orsp...U.S. In The Midst Of A Heroin Epidemic, But Many Overdose Deaths Can Be Prevented
...in, the peakoccurs in 5-10 minutes. The route of administration strongly affects heroin's potential tocause death or overdose. Most fatal and non-fatal overdoses are linked tointravenous administration. Most deaths occur among heroin users who are in their late 20s orearly 30s, have used the drug for 5-10 years...