Alzheimer's disease is not accelerated aging
Certain brain changes that are common in normal aging are not the beginnings of Alzheimer's disease. Recent research by cognitive aging experts suggests that changes related to Alzheimer's disease appear in distinct regions of the brain and reflect unique pathology compared with changes that occur in older adults without dementia. ... ..."We're getting a better understanding of the complex const...Study explores gene transfer to modify underlying course of Alzheimer's disease
Investigators at Rush University Medical Center have successfully initiated a new technique that uses gene therapy to deliver nerve growth factor into regions of the brain where neurons are degenerating, in order to prevent cell death and reverse cell atrophy, two hallmarks of Alzheimer's disease. If successful, this could be a major step toward modifying the course of the disease. Rush is the on...TANGO: towards faster prognosis of Alzheimer's and Parkinson's diseases?
Brussels A large number of diseases - including Alzheimer's disease, Parkinson's disease, and mad cow disease - are the result of proteins that erroneously assume the wrong shape, causing them to stick to each other. This phenomenon is perceptible, but up to now it has been difficult to predict. Researchers from the Flanders Interuniversity Institute for Biotechnology (VIB) at the Free Universit...DHA-rich diet protects brain from Alzheimer's damage, UCLA study shows
UCLA neuroscientists have shown for the first time that a diet high in the omega-3 fatty acid DHA helps protect the brain against the memory loss and cell damage caused by Alzheimer's disease. The new research suggests that a DHA-rich diet may lower one's risk of Alzheimer's disease and may help slow progression of the disorder in its later stages. The journal Neuron reported the findings on Se...Decreasing toxins in brains of Alzheimer's patients keep cognitive deficits at bay
(Philadelphia, PA) The ever-slowing capacity to clear the build-up of such toxins as isoprostanes and misfolded proteins that accumulate in the brains of Alzheimer's disease patients causes the death of cells involved in memory and language. Domenico Pratico, MD, Associate Professor of Pharmacology at the University of Pennsylvania School of Medicine, and colleagues have shown in a preliminary s...Early clinical treatment can halt progression of Alzheimer's disease, UCI researchers find
Irvine, Calif. -- UC Irvine neurobiologists have provided the first evidence that early clinical treatment of brain lesions can halt the progression of Alzheimer's disease....... Working on genetically modified mice, the researchers found that using specific antibodies to clear a certain type of brain lesion reversed abnormalities arising from a second type of brain lesion, which halted the progr...New UCF researchers, college will help fight Alzheimer's disease, cancer
ORLANDO, July 30, 2004 -- A new college of biomedical sciences will dramatically increase the University of Central Florida's research aimed at helping patients who suffer from Alzheimer's disease, cancer and other illnesses. ......The UCF Board of Trustees on Thursday, July 29, created the Burnett College of Biomedical Sciences and accepted a $10 million donation from Winter Park residents Al an...Altered protein involved in a novel link to Alzheimer's disease
New findings of the presence of beta amyloid in the brain of a mouse that overproduces a protein called p25 may help explain the occurrence of sporadic Alzheimer's (as opposed to the less common familial form of the disease) and also why stroke and high blood pressure increase the likelihood of developing Alzheimer's.... ...Dr. Li-Huei Tsai, a Howard Hughes Medical Institute investigator...AMA Alzheimer's Media Briefing
... ... BREAKING NEWS: How risk factors for stroke are related to cognitive decline of Alzheimer's... ... BREAKING NEWS: Distinguishing different types of dementia... ... CAN WE PREVENT ALZHEIMER'S?: Using tantalizing clues from recent studies to reduce risk... ... ADVANCES IN TREATMENT: Recent discoveries about Alzheimer's disease process leads to new treatment strategies... ... SOCIETAL CO...Study boosts confidence in potential screening tool for Alzheimers disease
A major study has confirmed the value of potential markers for identifying people with Alzheimer's disease. Scientists at the National Institute of Mental Health (NIMH) found that levels of two key indicators in spinal fluid distinguished clinically diagnosed Alzheimer's patients from controls with 89-92 percent efficiency. This matches or exceeds current clinical diagnostic methods, such as doc...Spinal cord injury and Alzheimer's risk among topics at American Chemical Society meeting
ORLANDO, Fla. More than 6,500 cutting-edge research findings will be presented at the 223rd national meeting of the American Chemical Society, April 7-11, in Orlando. Nearly 11,000 scientists are expected to attend the meeting, which will be held at the Orange County Convention Center. ... ...Highlights include:... ... ... ... ... ... Nurturing partnerships with t...Herpes tool allows researchers to customize Alzheimer's vaccine
Scientists have taken an important step toward creating a vaccine against Alzheimer's disease, customizing the response of the immune system with unprecedented precision.... ... Using a harmless form of the herpes virus, scientists at the University of Rochester Medical Center put into mice a payload of genetic information that created a carefully crafted immune response, one that muted the type...Alzheimer's may leave some forms of memory intact
Howard Hughes Medical Institute (HHMI) researchers have made the surprising discovery that people with Alzheimer's disease retain the capability for a specific form of memory used for rote learning of skills, even though their memories of people and events are extinguished.... ...The scientists' discovery suggests new strategies to improve training and rehabilitative programs that may...Cancer drug resistance research leads to possible therapeutic target for Alzheimer's disease
A protein that allows human cancer to resist multiple anticancer drugs also appears to play a key role in Alzheimer's disease, according to research conducted at Fox Chase Cancer Center. The protein, active in brain tissue, could be a target for new drugs to treat patients with Alzheimer's. ...The report will appear in advance online publication the of the prestigious Federation of American Soci...ADAM: Good enzyme for Alzheimer disease
Alzheimer Disease (AD), a progressive neurological disorder, is characterized by the presence of amyloid plaques in the brain. These plaques are comprised of aggregates of amyloid beta-peptides (AB peptides), which are believed to play a central role in disease development. Most strategies to prevent AD have been aimed at reducing the generation of amyloid beta-peptides. This is done by target...SPECT imaging shows promise for accurate, early diagnosis of Alzheimer's
Reston, VA -- Alzheimer's disease (AD) currently afflicts approximately 4.5 million Americans. One of the most feared diseases of old age, AD robs its victims of their memories and personalities long before it takes their lives. Curing or slowing the progress of AD has been a high priority in the scientific community, but an early and accurate diagnosis is equally important given that several ot...Study is another step in determining if curry can protect against Alzheimer's
Washington, DC -- A new study has found that curry, a common and popular cooking additive, could be an effective enhancer of an enzyme that protects the brain against oxidative conditions. This research is an important first step in determining whether curry could be preventive agent against acute neurodegenerative conditions, or reducing the progression of chronic and age associated neurodegene...Gladstone study reveals how genetic factor may increase risk for Alzheimer's disease
Researchers at the Gladstone Institute of Neurological Disease have identified processes that may explain how a key protein, apolipoprotein E4 (apoE4), contributes to the development of Alzheimer's disease. Their findings, described in the Journal of Neuroscience (March 10, 2004), include identifying where in the brain apoE4 is broken down into toxic fragments that can impair the function and sur...Possible mechanism for link between diabetes and Alzheimer's disease discovered
Boston, MA For some time, researchers have known that people with diabetes have a greater risk of developing Alzheimer's disease and other forms of dementia than those without diabetes, but the exact cause of this link has not been known. Now, a new study by researchers in Cologne, Germany, and at Joslin Diabetes Center in Boston, to be published this week online in the Proceedings of the Nation...New study may explain how fats damage neurons in Alzheimer's patients
SEATTLE, WA--Researchers studying alterations of cholesterol and another lipid in the brain cells of deceased individuals with Alzheimer's disease, suggest that they might someday be able affect the course of the disease by limiting the accumulation of those fats in the brain.... ...In a study released today at the 2004 AAAS (Triple-A-S) Annual Meeting in Seattle, and published online in the Proc...Genes influence memory in families with Alzheimer's disease
ST. PAUL, Minn. Genes play a strong role in how well our memory works, according to a study of families with more than one person with Alzheimer's disease. The study is published in the February 10 issue of Neurology, the scientific journal of the American Academy of Neurology. Located in DNA and RNA, a gene is a unit of inheritance that determines one or more traits.... ..."These results are ex...Researchers describe novel gene mutations associated with Alzheimer disease
CHICAGO Three mutations in genes associated with Alzheimer disease (AD) are described by researchers in the November issue of The Archives of Neurology, one of the JAMA/Archives journals....... Alzheimer disease (AD) is a complex neurodegenerative disorder often affecting the elderly and characterized by gradual loss of memory and cognitive decline, according to the article. AD is often accompa...Visualizing Alzheimer's disease
New Orleans, Nov. 12, 2003 -- Using recently developed techniques for imaging individual cells in living animals, a team led by researchers at Washington University School of Medicine in St. Louis has watched as Alzheimer's-like brain plaques damage mouse brain cells.... ...The results will be presented at 9 a.m. CT on Wednesday, Nov. 12, at the 33rd Annual Meeting of the Society for Neuroscience...Researchers find role RNA plays in progress of Alzheimer's disease
New Orleans Researchers at Ohio State University have found new clues to how free radicals can contribute to the development of Alzheimer's disease.... ...The study found that oxidation a type of damage to cells caused by free radicals can damage certain kinds of messenger RNA in the brain. That damage may be related to Alzheimer's.... ...Messenger RNA (or mRNA) is important because it turns D...Herpes research uncovers possible clue to Alzheimer's disease
Providence, R.I. -- Researchers at Brown University and the Marine Biological Laboratory at Woods Hole, Mass., have found a physical connection between the herpes simplex virus and amyloid precursor protein, a protein that breaks down to form a major component of the amyloid plaques that are consistently present in the brains of persons with Alzheimer's disease.... ...Amyloid precursor protein o...Distinct genes influence Alzheimer's risk at different ages
DURHAM, N.C. -- The genes that influence the risk of developing Alzheimer's disease may vary over the course of an individual's lifetime, a new study by Duke University Medical Center researchers finds. The team's results revealed two chromosomal regions not previously known to influence Alzheimer's disease: one linked to the disorder in families that first show symptoms early in life and another...New model of Alzheimer's enzyme may help refine future treatments
St. Louis, Oct. 27, 2003 -- An international team of scientists led by researchers at Washington University School of Medicine in St. Louis have found that the enzyme largely responsible for the development of Alzheimer's disease may work in a different way than previously thought. ...... "We're very excited to provide more insight into how this bizarre process takes place," says principal invest...Gene controls age at onset of Alzheimer's and Parkinson's diseases
DURHAM, N.C. - By applying a new technique that combines independent lines of genomic evidence, Duke University Medical Center researchers and colleagues have identified a single gene that influences the age at which individuals first show symptoms of Alzheimer's and Parkinson's diseases.... ...Such genes that can impact patients' age at onset for the two very prevalent neurological disorders are...A new molecular culprit for type II diabetes, Alzheimer's and Parkinson's
Therapies for Alzheimer's, Parkinson's and type II diabetes should be directed toward a new molecular culprit the precursor to the clumps of abnormal proteins that have garnered attention for the last century.... ...Israeli scientists say they have solid evidence that the precursor molecules called protofibrils are the problem molecules in type II diabetes, and their results support a similar...Leisure activity may reduce risk of Alzheimer's, says USC research team
Participation in a greater overall number of leisure activities during early and middle adulthood is related to lower risk of developing Alzheimer's disease, according a team of researchers headed by University of Southern California graduate student Michael Crowe. He and his colleagues - University of South Florida faculty member Ross Andel (a recent USC PhD), USC and Karolinska Institute profes...New research technique provides unique glimpse into Alzheimer's disease
St. Louis, Oct. 1, 2003 -- A team led by researchers at Washington University School of Medicine in St. Louis, in collaboration with researchers at Eli Lilly and Co. in Indianapolis, have developed a new technique that, for the first time, provides a way to dynamically study proteins known to be related to Alzheimer's disease in the fluid between brain cells, called interstitial fluid. ... ...Usi...Toxic protein could explain Alzheimer's and lead to breakthroughs
EVANSTON, Ill. -- Researchers at Northwestern University have discovered for the first time in humans the presence of a toxic protein that they believe to be responsible for the devastating memory loss found in individuals suffering from Alzheimer's disease....... An understanding of this key molecular link in the progression of Alzheimer's could lead to the development of new therapeutic drugs c...Study shows enzyme helps guard against Alzheimer's disease
Boston, MA The discovery that an enzyme called Pin1 can prevent tangles of proteins from forming in the brain's nerve cells as occurs in patients with age-dependent Alzheimer's disease -- is described in a new study led by investigators at Beth Israel Deaconess Medical Center (BIDMC) and Harvard Medical School. These findings, which appear in the July 31, 2003 issue of the journal Nature, offer...New theory of cell death proposed in UCSB Alzheimers research
(Santa Barbara, Calif.) Alzheimer's disease, the most common form of dementia, currently affects four million Americans a number expected to increase to 14 million by the year 2050. Not surprisingly, researchers are racing to understand the disease so that effective therapies can be developed. ...To develop a drug that could arrest or prevent Alzheimer's disease, scientists must first understa...Common treatment for depression is safe and effective for Alzheimer's patients
Researchers at Johns Hopkins have shown that a drug, Zoloft, commonly used for depression, also improves quality of life and alleviates disruption in daily activities for the one-quarter of Alzheimer's patients who also suffer from major depression. However, the drug did not improve patients' cognitive abilities, such as thinking, remembering and learning, which are often impaired in Alzheimer's...Study links amyloid plaques in Alzheimer's brains to genes vital to normal memory
Tampa, FL (June 27, 2003) -- The buildup of Alzheimer's-associated amyloid plaques in the brain dramatically inhibits several genes critical to memory and learning, University of South Florida College of Medicine researchers have found.... ...The strong link between the decreases in select memory genes and amyloid accumulation was observed both in mice genetically engineered to develop memory los...Emory University researchers uncover novel self-assembly of Alzheimer's amyloid fibrils
Researchers at Emory University and Argonne National Laboratory have discovered a new method to manipulate the self-assembly and formation of amyloid fibrils, a major component of brain plaques associated with Alzheimer's disease, thereby opening new avenues for examination of their formation and for the construction of robust nanotubes that have potential applications in research, industry and m...Lithium shows promise against Alzheimers in mouse model
An enzyme crucial to formation of ...lithium stems the accumulation of beta amyloid, which forms Alzheimer's plaques, scientists funded by the National Institutes of Health (NIH) report in the May 22, 2003 Nature. Inhibiting the enzyme, glycogen synthase kinase 3 alpha (GSK-3 alpha), also blocks formation of neurofibrilar...Scientists at UCSB link brain plaques in Alzheimers disease to eye disease
(Santa Barbara, Calif.) Scientists at the Center for the Study of Macular Degeneration at the Neuroscience Research Institute of the University of California, Santa Barbara have found a link between the brain plaques that form in Alzheimers disease and the deposits in the retina that are associated with age-related macular degeneration (AMD). AMD is a disease that leads to loss of central vision...Insulin-degrading enzyme may affect risk of Alzheimers disease
DALLAS May 5, 2003 Low levels of an enzyme that degrades insulin could increase the risk for Alzheimer's disease, according to a new study in mice by doctors at UT Southwestern Medical Center at Dallas.... ...The study, to be published online this week and in a future issue of Proceedings of the National Academy of Sciences, is among the first to show a relationship between the enzyme insulysin...