Purdue Study Aims To Boost MRI Capabilities
...tus consists of a very powerful gradient amplifier assembly and magnetic coils to produce pulsed magnetic fields of greater intensity than can be applied in a commercial magnetic resonance imager. This system, developed at Purdue over two years, will allow the group to manipulate and measure tiny changes in t...Researchers Construct Genetic Map For Dogs
... Center." Cornell became the catalyst that allowed assembly of the map to begin in earnest two years ago." "We were able to provide a number of highly informative pedigrees of dogs that, for several years, had been bred specifically for genetic studies such as these," said Gustavo Aguirre, V.M.D., Ph.D., prof...New Molecular Switch Is The Key That Unlocks DNA Repair
...ch. Dr. Fishel believes that the correct assembly of the repair machinery allows the switch to function properly. “hMSH2-hMSH6 binds [to the mismatched nucleotide pair] and once this whole complex is assembled, it flicks the switch,” he says. According to Dr. Fishel, ...Early Career Development Grants Foster Faculty Research And Education
...NSF Acting Deputy Director Joseph Bordogna. "This assembly of researchers, at the early stages of what we hope will be long and productive careers,gives us great confidence in the future of our universities and colleges and their impact on thenation's welfare." The CAREER program encompasses all ar...Mystery Of Vital Cell Protein Solved After 30 Years
... on tubulin are firmly linked," saysNogales. "The assembly of tubulin and its regulation through dynamicinstability results from the fine tuning of the three components." To produce their model, the Berkeley Lab researchers first polymerizedtubulin proteins under the same conditions in which microtu...DNA Enzyme Works In Crystal Form; Yields New Insights Into Gene Copying
... researchers studied is part of acomplex molecular assembly line that is central to all cell division. A cellp...active site"-- the pocket in the moleculewhere DNA assembly takes place. They crystallized a polymerase that Braman of Stratagene had isolatedfrom a re...Good Ergonomics Is Good Economics
... in a much greater increase in productivity. Fine assembly workstations. Typical workstations at a major electronics assembly plant result in poor postures and resultant work-related musculoskeletal disorders. Valery Venda of ...... a current. This is the first demonstration ofself assembly of any functioning electronic component," said physicist UriSivan, who conducted the research with Erez Braun, another physicist, andchemist Yoav Eichen. Wires are the foundation of any circuit because they link circuitcomponents to each othe...Hultgren Receives Prestigious Eli Lilly Award
...gren's team is studying the structure,function and assembly of E. coli P and type 1 pili, whose tips contain a...aperone protein.Without this essential link in the assembly line, E. coli cannot make pili andtherefore can no longer colonize the urinary tract or cause diseas...Insights Into The Proteasome - A Fascinating Macromolecular Machine For Protein Degradation
...ccus offered an excellent means to dissect the assembly pathway of the complex. The team of Wolfgang Baumeister isolated and characterized the first bacterial proteasome, and managed to set up a system, which allows to monitor its biogenesis in vitro . Rhodococcus a - and b -subunits s...... service as a chemistry degree requirement Self assembly of materials Role of the contract laboratories in the development of agrochemicals 43 Award addresses, including two Nobel laureates, the inventor of Post-ItR Notes, and an advocate for encouraging disadvantaged students into careers inth...RNA-Dendritic Cell Combo Shows Promise As A Universal Cancer Vaccine
...ient. Such a vaccine can be produced in an assembly line fashion, and in fact,a new cell processing laboratory at Duke is now gearing up to produce massquantities of this vaccine. "While we need the RNA from a patient, we do notneed to determine the antigen it expresses, or a patient's immune fingerpr...How Did Life Begin? Biochemical Evolution On Chemical Surfaces
...onal channels could have provided the template for assembly of onlyone version of the amino acids into the first primitive proteins. Smith plans a trip to Australia, where some of the oldest andleast-metamorphosed rocks and minerals are found, to look for more naturallyoccurring organophilic zeolites ...Washington University Professor Receives Young Investigator Award In Microbiology
...ork on pilus genetics, biosynthesis, structure and assembly ofpili in pathogenic bacteria and the applications of this basic knowledge ofdevelopment of vaccines have given him recognition nationally andinternationally. He was recently elected Chair of the next Gordon Conference onbacterial adhesion. He was n...New Vancomycin Structure May Point To Path For Overcoming Antibiotic Resistance
... findings suggest that the two-molecule vancomycin assembly createdat Lilly -- referred to as a dimer -- may be configured in a so-calledface-to-face orientation of the molecules rather than the back-to-backarrangement thought to be the norm for vancomycin. "The whole problem of making a drug that wor...Ionotropic Glutamate Receptors Share Tetrameric Structure With The Voltage GatedPotassium Channel
...igand-gated ion channels that are assumed to be an assembly of five subunits, tetramers (Science,...e receptor is thought to be formed by assembly of five proteins, as is assumed for all neurotransmitter activated receptors. This view......ach a full meter through the body.With microtubule assembly disrupted, these cells can die. "The bottom line here is that there is loss of tau function with thesemutations, and the function of tau is to stabilize microtubules," says VirginiaM.-Y. Lee, PhD, a professor of pathology and laboratory medic...Method May Be Key In Combating Diarrhea In Animals And Children
... suspected leptin activity thatmay be required for assembly of new viruses ininfected cells. "We believe this activity, which nobody has seen before, is either involved inthe entry of the virus into the host intestinalcell, or in holding the virus together," Mark Kuhlenschmidt said. "All of thelayers have to ...Scientists Show For The First Time How Leprosy Bug Targets Peripheral Nerves
...eculecalled dystroglycan, a component of a protein assembly called thedystrophin-glycoprotein complex, is one of the major laminin receptors of theSchwann cell. Dystroglycan exists in two subunits, the outer membrane alphasubunit and the transmembrane beta subunit. alpha-Dystroglycan interacts withlaminin-2 i...Growing Up On Their Own: Smart Plastics Organize Themselves Into Useful Optical Devices
...to a material, orproviding a template to begin the assembly process, then somehow removing thestarting material. The Rochester team believes its is the first photonic crystal thatliterally grows itself. In the process, known as hierarchical self-assembly,hollow spheres stack themselves into larger str...