UCI scientists successfully target key HIV protein; breakthrough may lead to new drug therapies
...ly known as HIV, is known to cause AIDS. The virus attacks the body's immune system, making the body vulnerable to infections and certain cancers. Symptoms of acute HIV infection may include fever, headache, fatigue and enlarged lymph nodes. The virus is spread most commonly by having unprotected sex with an...9/11 search-and-rescue dogs exhibit few effects from exposure to disaster sites
...s deployed following the Sept. 11, 2001, terrorist attacks have not suffered either immediate or short-term effects from exposure to the disaster sites, researchers from the University of Pennsylvania School of Veterinary Medicine report. The findings, presented in the Sept. 15 issue of the Journal of the A......eat, rye, and barley products, their immune system attacks and damages the lining of the small intestine. Development of this disease has been linked to the transformation of normal immune cells, called cytotoxic T lymphocytes (CTLs), that normally protect the body from ingested pathogens into renegade lymph...New research shows air pollution can reduce children's lung function
...creases, the risk of respiratory disease and heart attacks increases." Deficits in lung function are associated with other short- and long-term effects. "If children or young adults with low lung function were to have a cold, they might have more severe lung symptoms, or wheezing," says W. James Gauderman, P...Heart gene yields insights into evolution, disease risk
... the men would have suffered 43 percent more heart attacks had the positive selection for the gene variant no... the men would have suffered 43 percent more heart attacks had the positive selection for the gene variant not occurred. "We really don't know why this selecti...Broken arms and collateral damage: clues to predator-driven evolution
... lose---and regenerate---their arms as a result of attacks by fish, Baumiller and Gahn reasoned that arm regeneration in fossil crinoids would be a good indicator of predator-prey interactions in the geologic past. To test their idea, they examined more than 2,500 Paleozoic crinoids for evidence of arm regen...The future of HIV therapeutics is brightening, according to Gladstone Institutes Director
... its Vif, or viral infectivity factor, gene." HIV attacks APOBEC3G through its Vif protein. GIVI scientists were the first to show that Vif not only targets intracellular APOBEC3G for accelerated destruction, but also impairs new production of this antiviral factor. Vif's combined effects effectively overco...Highlights of American Chemical Society national meeting in Philadelphia, Aug. 22-26
...) Protecting against possible future bioterrorism attacks -- Following the mailing of anthrax spores to sel...pect to responding to possible future bioterrorism attacks and to preparing for and protecting against such attacks. ( CHAS 11 , Monday, Aug. 23, 2:25 p.m., Lo...Images reveal how rotavirus - leading cause of diarrhea - enters cells
... targets that the immune system recognizes when it attacks the virus and protects against infection. "The work is a clear example of the way in which structural studies can contribute to new good ideas about strategies for vaccines," says Senior Investigator Stephen Harrison, Ph.D., a Howard Hughes Medical ...Possible new cure for psoriasis
...hronic inflammation of the skin caused by constant attacks by the body's own immune system, to which the keratinocytes react with feverish activity in the cell division field. The researchers now intend to test their method on animals, using naked mice on which they have transplanted the skin tissue of psori...Climate change could doom Alaska's tundra
...fires and a likely increase in insect and pathogen attacks on trees are also projected by some of the most sophisticated computer models yet developed, Bachelet said."The effects of climate change in Alaska will be among the most visible in the world," Bachelet said. "The tundra has no place else to go, and ...Study: Mothers turn fearless when peptide level drops
...ior. As the levels of CRH increased, the number of attacks and the duration of them dramatically decreased. The results show, for example, that while the mice with the lowest levels of CRH attacked more than 20 times for the duration of about 45 seconds, the mice with moderate levels of the peptide a...A pathway to blocking autoimmunity
... potential for fighting diseases in which the body attacks its own cells. Natural killer T (NKT) cells maintain the immune system's balance between destruction and tolerance, a mechanism that is off kilter in autoimmune diseases such as type 1 diabetes and irritable bowel disease. "If we can regulate ...Annals of internal medicine tip sheet, July 20, 2004
...ake recommendations on safe air travel after heart attacks and prevention of in-flight deep venous thrombosis. Authors also present a nine-item pretravel checklist for patients with cardiovascular disease. 2. Long-term antibiotic doesn't ease gulf war illnesses A 12-month course of the broad-spectru...... diseases, however, the immune system misfires and attacks the body, inflaming nerve, liver, muscle and other cells. Because of its central role in initiating inflammation, NF-kB is being intensely scrutinized by pharmaceutical researchers looking for new therapies for autoimmune diseases like lupu...Vioxx in high doses causes hypertension
...he rate of serious heart problems, including heart attacks and heart-related deaths, compared to patients not on the drug. Other groups have reported similar findings among high-dose Vioxx users: an increased risk of heart attack and congestive heart failure, a rise in blood pressure and a greater incidence ...Society for conservation biology conference
... Garhwal district of the Indian Himalayas, leopard attacks on humans have increased due to habitat fragmentation and decline in wild prey. Getting the Most from International Youth Environmental Education, A Lesson from Venezuela Environmental education is frequently recommended as a way to change lo...Genetic mutation found that is major contributor to type 1 diabetes
... initiating an autoimmune response that eventually attacks the patient's own tissue. They already are exploring the gene's potential role in other autoimmune diseases as well such as lupus, thyroid disease, arthritis and multiple sclerosis. SUMO-4 is the fourth gene identified that contributes to type 1 diab...Protein controls acid in cells by direct detection of volume changes, study finds
... prevent cell death, which often accompanies heart attacks and strokes. In ischemia, where the blood supply is cut off to cardiac cells or brain cells, cells become very acidic. As the body's normal metabolism gets going again, the NHE1 system starts pumping out the accumulated acid, exchanging the acid for ...... trying to determine precisely how flavohemoglobin attacks NO, in hopes of finding a weakness that can be exploited with drugs. In addition to Candida, Gustin's group is also interested in finding out whether other fungal pathogens like Aspergillus -- a more deadly species than Candida -- use the same NO def...