Herpes-Based Gene Therapy Is Key To Promising Liver Tumor Vaccine
...together by Drs. Federoff and Fong, is known as an autologous tumor vaccine. "We're trying to exploit the immune system's ability to specifically recognize and kill tumor cells," says Dr. Federoff. The physicians used a herpes simplex virus -- the same one that causes blisters and cold sores in people and anima...15 Drugs, Dyes And Other Chemicals Newly Listed As Known Or Likely Human Carcinogens
... patients with refractory malignancies treatedwith autologous bone transplantation. Newly listed as Reasonably Anticipated to be Human Carcinogens: AZACITIDINE, a drug used to treat acute leukemia. p-CHLORO-o-TOLUIDINE and its HC1 salt, used to produce azo dyes forcotton, silk acetate and nylon and as interm......herapy, or by chemoradiotherapy followed by purged autologous bone marrowtransplants. In the latter treatment, p...ation chemotherapy. "This study shows that purged autologous bone marrow transplant after high dosechemoradiotherapy provides the best chance of survival in adva...Engineered Neo-Organs For Bladder Replacement
...ladder-shaped biodegradable polymer that delivered autologous cells from the bladder epithelium, plus smooth mus...en expanded separately from a previously harvested autologous bladder biopsy. The researchers performed preoperative and postoperative urinary flow and X-ray stu...Scientists Make Progress Toward Gene Therapy For HIV Infection
...minethis approach in the more practical setting of autologous infusions in patientsundergoing treatment with highly active antiretroviral therapy. The patientsare being treated with their own cells, which have been genetically modified inthe same way. In a related paper in the July 1998 issue of Nature Medicin......tration of an experimental cancer vaccinefollowing autologous stem cell transplant can increase survival and dec... Ph.D., THERATOPEO vaccine was well toleratedafter autologous stem cell transplant and in preliminary data may have improvedoutcomes. These results need to be c......ccinated patients supports the true promise of our autologous vaccines, which is to help a patient's own immune system contain, fight, and kill tumor cells. These data further encourage us to evaluate the clinical utility of the AC Vaccine not only in melanoma and ovarian cancer (O-Vax™), but in other can...AVAX Technologies' AC Vaccine™ improves relapse-free survival
...inical data on its AC Vaccine™ technology, an autologous cell cancer vaccine, at the 91st Annual Meeting of...tform technology to demonstrate the promise of our autologous vaccines as an effective treatment for a variety of late stage cancers." AVAX's AC Vaccines are ......ights to manufacture and market AVAX Technologies' autologous cancer vaccine (AC Vaccine™) for melanoma, M-Vax™, in Australia and has similar rights in New Zealand. M-Vax is AVAX's lead cancer vaccine and is currently being evaluated in the U.S. in a multicenter pivotal registration trial for Stage I......(ASCO) (May 20-23) in New Orleans on the company's autologous cell vaccine (AC Vaccine™) O-Vax™, for ovarian cancer. The data gathered from an ongoing Phase 1/2 trial of O-Vax in patients with advanced ovarian cancer extend earlier findings indicating that O-Vax induces a positive immunological and c...... (ASCO)(May 20-23) in New Orleans on the company's autologous cell vaccine (AC Vaccine™) M-Vax™ for the ...AC Vaccine™ technology. It is our belief that autologous vaccines, which are made from a patient's own tumor cells, provide potential therapies for patients ...Study identifies new source of stem cells
...d. Importantly, SKPs also represent a potentially autologous (i.e. originating from within the same individual) stem cell source that can generate neural cell types damaged in spinal cord injury or Parkinsons disease. This means that complications seen in donor transplantations are avoided as the patient's ow...T cell responses in aplastic anemia
...gly, these JZ1.1 T cells appear to be specific for autologous stem cells derived from the patient at a time of severe disease marrow cells derived from a healthy, MHC-matched control donor, or even from the patient after successful treatment, are not killed by exposure to JZ1.1 cells. Hence, it appears that T ...Scientists use gene therapy to correct sickle cell disease in mice
...therapy for sickle cell disease would be done with autologous transplantation. In this procedure, some of the patients own bone marrow cells would be removed and genetically corrected. The remaining original marrow would be partially destroyed to "make room" for the genetically altered cells, which would then b...New gene therapy shows promise for hemophiliacs
...lood sample taken from the patient as a source for autologous BOECs. (This use of autologous cells eliminates the concern for immunological compatibility or disease-tainted blood sources). The ...A new role for a versatile stem cell
...o develop therapeutic engraftment techniques using autologous cells is the ability to generate uniform populations of a desired cell type ex vivo. Verfaillie's group has found that a single MAPC can be passaged for many cell divisions in an undifferentiated state or can be induced to differentiate along any of ...Muscle derived cell transplants offer alternative incontinence therapy says Pitt study
...ool of Medicine have found that, in animal models, autologous skeletal muscle derived cell (MDC) transplants offer a safer, more effective and longer lasting treatment for urinary incontinence than existing methods. In the procedure, muscle cells are taken from the individual, purified and cloned, and then rein...Prize to Weizmann Institute professor for landmark work in stem cell transplantation
...unrelated donor, physicians intended to perform an autologous transplant (using the patient's own stem cells), but by the time the transplant was ready, the patient's disease had relapsed. He underwent additional chemotherapy but failed to respond. By that time, his leukemia had progressed to a critical stage a...JCI Table of Contents, March 14, 2003
...eictransplants, various gene therapy approaches in autologous stem cells areunder development. Encouraged by the...ection of these progenitors couldyield a source of autologous cells suitable for genetic manipulation andsubsequent transplantation. CONTACT: Catherine M. Verfa......tential for ex vivo expansion,differentiation, and autologous transplantation"....