Green tea research leads to gum and other products
...t of irreversible cell damage. Chronic exposure to carcinogens and certain drugs also can damage salivary gland cells. Dr. Hsu and his colleagues found that when they added EGCG to cells, the polyphenols increased ROS levels in cancer cells but reduced them in healthy salivary gland and skin cells. "All of our d...DFG presents the 2004 MAK and BAT value lists
...ical guideline values and exposure equivalents for carcinogens (BAT-Werte, BLW und EKA) includes a new listing, i.e. the exposure equivalents for easily soluble nickel compounds (EKA). The Senate Commission produced detailed scientific justifications for each new entry and change in the 2004 MAK and BAT value li...Study supports association between HPV infection and head and neck cancer
...tiologies: one driven by exposure to environmental carcinogens (i.e., tobacco and alcohol) without HPV involvement and the other involving infection with transcriptionally active [HPV]," the authors write. In an editorial, Li Mao, M.D., and Waun Ki Hong, M.D., of the University of Texas M. D. Anderson Cancer Cen...Cutting back on cigarettes: when less is more
...eflects general exposure to hundreds of toxins and carcinogens in smoke while cotinine, a metabolite of nicotine, reveals how much nicotine has been absorbed over time. The scientists also carefully observed the way the women smoked scientists call it "smoking topography" measuring such things as the number an...Cancer rates in teens and early 20s rising
...xposure of a young child or fetus to environmental carcinogens during periods of rapid growth and development might lead to higher cancer risks in young adults than adult exposure at similar doses would to the risk of cancer in later life." Infection in early life could be important in lymphoma with ri...Other highlights in the January 21 issue of JNCI
...es appearing in the January 21 JNCI: Exposure to carcinogens not proportionally decreased by reduction in smoking: http://www.eurekalert.org/emb_releases/2004-01/jotn-etc011504.php Radiotherapy improves survival after breast-conserving surgery for early-stage breast cancer: http://www.eurekalert.org/emb_rel...Scientists announce long-sought mouse model of human pancreatic cancer
...weight loss. The genes mutate for various reasons: carcinogens such as tobacco smoke (smoking is a risk factor for pancreatic cancer), possibly dietary components and advancing age (mistakes in the DNA code of genes pile up and the body's DNA repair mechanisms fail to keep pace). Several particular mutations hav...Better model of cancer development sheds light on potential angiogenesis target
...ins investigator's new model, mice were exposed to carcinogens placed on their skin and allowed to gradually develop cancer. Results showed a completely opposite outcome with respect to Id1: all mice with the Id1 gene turned off developed more tumors that also were larger than in previous studies. "Clues to pr...Researchers find genetic link to prostate cancer
...ons in a gene that controls the body's response to carcinogens in the environment as well as hormones natural to ...some men leaves them more susceptible to potential carcinogens in the environment or hormones in the body that could trigger the disease." The researchers analyze...DFG presents the new MAK and BAT Value List 2003
...plied so far. In the course of examining suspected carcinogens in category 3 by establishing categories 4 and 5, .... Beryllium was reclassified to category 1, proven carcinogens in humans. This year, ochratoxin A was classified in category 2, i.e., it should be considered carci...Two genes may interact to increase risk of lung cancer in smokers
...ay and the cell cycle control pathway, exposure to carcinogens present in cigarette smoke and resultant lung cancer risk. Cancer is caused when damage in cells results in unregulated cellular growth. When DNA repair genes (whose job is to ensure that genetic information is accurately copied when cells divide) ar...The area where carcinogens settle may be a key factor in developing lung cancer
...carcinogenic particles and particles with absorbed carcinogens from cigarette smoke at the airway's carinas -- the ridge separating the openings of the right and left main bronchi at their junction with the trachea -- is a potentially important mechanism for human pulmonary carcinogenesis. Animal studies indica...Vehicle traffic associated with increased carcinogen levels
...een vehicle traffic and curbside concentrations of carcinogens benzene, 1,3-butadiene and particle-bound polycycl...ctoral student Amir Sapkota measured levels of the carcinogens benzene, 1,3-butadiene and PAHs at a tollbooth at Baltimore's Harbor Tunnel over a one week period. ...Gene researchers close in on nicotine's 'evil cousin'
...o-leaf microbes, converts to nitrosamines - potent carcinogens - during the tobacco-curing process. If researchers could find the genetic location of the enzyme that removes nicotine's methyl group, tobacco with little or no nornicotine would be possible. That's the task of Dr. Ralph Dewey, professor of crop sc...Microorganisms are cleaning up Boston Harbor, UMass study finds
...ish. Some PAHs are highly toxic, and are suspected carcinogens in humans. The UMass team was prompted to study the issue after earlier research by Lovley found that benzene degrades in the absence of oxygen, in certain conditions. PAHs are essentially groups of two to five benzene rings, Lovley noted. His colla...Food expert says more tests needed before fried foods are tabled
...ato chips. "People don't understand that traces of carcinogens can be found in pretty much all of our foods," Santerre said. "Detecting a carcinogen is not a reason to change dieting patterns. We also need to think about the dose, since small doses can be harmless while high doses can be harmful. It is the job o...Researchers create new strategy for removing arsenic from soil
...ic arsenic species are classified as Group A human carcinogens and cause skin lesions, lung, kidney and liver cancers, and also damage the central nervous system. The paper notes that hundreds of U. S. Superfund sites are listed on the National Priority List as having unacceptably high levels of arsenic and are ...Prescription drug pollution may harm humans, aquatic life
...pose a human health risk, although the presence of carcinogens or teratogens even at low concentrations is of potential human health concern. Also at the meeting, Michael L. Blumenfeld, a 22-year-old Johns Hopkins undergraduate from Timonium, Md., will present a new method of detecting tiny amounts of several dr...Other highlights in the Feb. 20 issue of JNCI
...tecting cells from the damaging effects of tobacco carcinogens may have a higher risk of developing pancreatic cancer. The gene, GSTT1, is a member of a family of enzymes called glutathione S-transferases, which are responsible for protecting cells from carcinogen-related cell damage. The study, which appears i...Canadian researchers find cancer suspect from grilled meat in human milk
...t cancer. PhIP is one of the few suspected mammary carcinogens found in breast milk that is almost exclusively associated with grilled meat, says Josephy. It is also the first member of its chemical class, a group of highly mutagenic compounds known as heterocyclic amines (HCAs), to be found in human breast milk...